Dogmas and controversies in the handling of nitrogenous wastes: Excretion of nitrogenous wastes in human subjects

Journal of Experimental Biology

Volumn 207, Issue 12, 2004, Pages 1985-1991

  Kamel, Kamel S ^a   Cheema Dhadli, Surinder ^a   Shafiee, Mohammad A ^a   Halperin, Mitchell L ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Acid base; Ammonium; Human; Urea; Urine osmolality; Water

Indexed keywords

CALCIUM; OXALIC ACID DERIVATIVE; QUATERNARY AMMONIUM DERIVATIVE; UREA; VASOPRESSIN DERIVATIVE;

BIOLOGICAL MODEL; HUMAN; KIDNEY MEDULLA; METABOLISM; PH; PHYSIOLOGY; REVIEW; URINE; UROLITHIASIS;

CALCIUM; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY MEDULLA; MODELS, BIOLOGICAL; OXALATES; QUATERNARY AMMONIUM COMPOUNDS; UREA; URINARY CALCULI; VASOPRESSINS;

EID: 3042655542     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: 10.1242/jeb.01019     Document Type: Review

References (22)

1. Asplin, J. R. (1996). Uric acid stones. Semin. Nephrol. 16, 412-424.
2. Cheema-Dhadli, S., Lin, S.-H. and Halperin, M. L. (2002). Mechanisms used to dispose of a progressively increasing alkali load in the rat. Am. J. Physiol. 282, F1049-F1055.
3. Coe, F. L. and Parks, J. H. (2000). Pathogenesis and treatment of nephrolithiasis. In The Kidney: Physiology and Pathophysiology, vol. II (ed. D. W. Seldin and G. Giebisch), pp. 1841-1867. Philadelphia PA: Lippincott Williams & Wilkins.
4. Gamble, J. L., McKhann, C. F., Butler, A. M. and Tuthill, E. (1934). An economy of water in renal function referable to urea. Am. J. Physiol. 109, 139-154.
5. Gowrishankar, M., Lenga, I., Cheung, R. Y., Cheema-Dhadli, S. and Halperin, M. L. (1998). Minimum urine flow rate during water deprivation: Importance of the permeability of urea in the inner medulla. Kidney Int. 53, 159-166.
6. Halperin, M. L., Aujla, P., Shafiee, M., Cheema-Dhadli, S. and Chong, C.-K. (2002). Urine flow rate and restful sleep without forming kidney stones. Can. Fed. Biol. Soc. 45, 98.
7. Halperin, M. L., Ethier, J. H. and Kamel, K. S. (1989). Ammonium excretion in chronic metabolic acidosis: risks and benefits. Am. J. Kidney Dis. 9, 265-268.
8. Halperin, M. L. and Jungas, R. L. (1983). Metabolic production and renal disposal of hydrogen ions. Kidney Int. 24, 709-713.
9. Kamel, K. S., Cheema-Dhadli, S. and Halperin, M. L. (2002). Studies on the pathophysiology of the low urine pH in patients with uric acid stones. Kidney Int. 61, 988-994.
10. Kamel, K. S., Lin, S.-H., Cheema-Dhadli, S., Marliss, E. B. and Halperin, M. L. (1998). Prolonged total fasting: a feast for the integrative physiologist. Kidney Int. 53, 531-539.
11. 3. Nature 339, 478-480.
12. Knepper, M. A., Packer, R. and Good, D. W. (1989). Ammonium transport in the kidney. Physiol. Rev. 69, 179-249.
13. Madison, L. L. and Seldin, D. W. (1958). Ammonia excretion and renal enzymatic adaptation in human subjects, as disclosed by administration of precursor amino acids. J. Clin. Invest. 37, 1615-1627.
14. Nielsen, S., Frokiaer, J., Marples, D., Kwon, T. H., Agre, P. and Knepper, M. A. (2002). Aquaporins in the kidney: from molecules to medicine. Physiol. Rev. 82, 205-244.
15. Relman, A., Lennon, E. and Lemann, J., Jr. (1961). Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. J. Clin. Invest. 40, 1621-1630.
16. Robertson, G. L. (2000). Vasopressin. In The Kidney: Physiology and Pathophysiology, vol. 4 (ed. D. W. Seldin and G. Giebisch), pp. 1133-1152. Philadelphia PA: Lippincott Williams & Wilkins.
17. Sajo, I. M., Goldstein, M. B., Sonnenberg, H., Stinebaugh, B. J., Wilson, D. R. and Halperin, M. L. (1981). Sites of ammonia addition to tubular fluid in rats with chronic metabolic acidosis. Kidney Int. 20, 353-358.
18. Sands, J. M. (1999). The medullary collecting duct urea transporters. Curr. Opin. Nephrol. Hyperten. 8, 499-504.
19. Simpson, D. (1971). Control of hydrogen ion homeostasis and renal acidosis. Medicine 50, 503-541.
20. Vasuvattakul, S., Gougoux, A. and Halperin, M. L. (1993). A method to evaluate renal ammoniagenesis in vivo. Clin. Invest. Med. 16, 265-273.
21. Verlander, J. W., Miller, R. T., Frank, A. E., Royaux, I. E., Kim, Y.-H. and Weiner, I. D. (2003). Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney. Am. J. Physiol. 284, F323-F337.
22. Weiner, I. D. and Verlander, J. W. (2003). Renal and hepatic expression of the ammonium transporter proteins, Rh B Glycoprotein and Rh C Glycoprotein. Acta Physiol. Scand. 179, 331-338.