Synthesis and biological evaluation of a phosphonate analog of the natural acetyl cholinesterase inhibitor cyclophostin

Journal of Organic Chemistry

Volumn 73, Issue 21, 2008, Pages 8386-8391

  Bandyopadhyay, Saibal ^a   Dutta, Supratik ^b   Spilling, Christopher D ^a   Dupureur, Cynthia M ^b   Rath, Nigam P ^b  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL REACTIONS; SUBSTITUTION REACTIONS;

ALLYLIC CARBONATES; BIOLOGICAL EVALUATIONS; CHEMICAL EQUATIONS; CHOLINESTERASE INHIBITORS; CIS ISOMERS; DEBENZYLATION; DEMETHYLATION; DIASTEREOMERS; PHOSPHONATE; SELECTIVE HYDROGENATIONS; SEPARABLE MIXTURES; TWO SOURCES;

ISOMERS;

ACETOACETIC ACID; ALLYL COMPOUND; CARBONIC ACID DERIVATIVE; CHOLINESTERASE INHIBITOR; CYCLOPHOSTIN; DIMETHYL [1 (METHOXYCARBONYLOXY) 4 (BENZYLOXY) 2 BUTENYL]PHOSPHONATE; LACTONE DERIVATIVE; METHYL 2 ACETYL 3 (BENZYLOXYMETHYL) 5 (DIMETHOXYPHOSPHORYL)PENT 4 ENOATE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DEBENZYLATION; DEMETHYLATION; DIASTEREOISOMER; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION; ISOMER; REACTION ANALYSIS;

CHOLINESTERASE INHIBITORS; CYCLIZATION; HYDROGENATION; LACTONES; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55249104072     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo801453v     Document Type: Article

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