Influence of ketone bodies on oxidative stress parameters in brain of developing rats in vitro

Metabolic Brain Disease

Volumn 23, Issue 4, 2008, Pages 411-425

  Beskow, Ana Paula ^c   Fernandes, Carolina Gonçalves ^c   Leipnitz, Guilhian ^a   Da Silva, Lucila De Bortoli ^c   Seminotti, Bianca ^a   Amaral, Alexandre U ^a   Wyse, Angela T S ^a   Wannmacher, Clóvis M D ^a   Vargas, Carmen R ^a   Dutra Filho, Carlos S ^a   Wajner, Moacir ^a,b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^c UNIVERSIDADE LUTERANA DO BRASIL   (Brazil)

Author keywords

Acetoacetyl CoA thiolase deficiency; Cerebral cortex; Ketone bodies; Oxidative stress; Succinyl CoA: 3 oxoacid CoA transferase deficiency

Indexed keywords

3 HYDROXYBUTYRIC ACID; 3 OXOACID COENZYME A TRANSFERASE; ACETOACETIC ACID; ACETYL COENZYME A ACETYLTRANSFERASE; CARBONYL DERIVATIVE; CATALASE; DICHLORODIHYDROFLUORESCEIN DIACETATE; GLUTARIC ACID DERIVATIVE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; KETOACIDOSIS; LIPID PEROXIDATION; NEUROLOGIC DISEASE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; RAT; SUPERNATANT;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ANIMALS; ANTIOXIDANTS; CEREBRAL CORTEX; FLUORESCEINS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; KETONE BODIES; LIPID PEROXIDATION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

RATTUS;

EID: 55149098096     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-008-9108-3     Document Type: Article

References (41)

1. MA Abdelmegged AK Klim KJ Woodcroft RF Novak 2004 Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-actived protein kinase in primary cultured rat hepatocytes: role of oxidative stress J Pharmacol Exp Ther 310 728 736
2. HJ Adrogue H Wilson AE Boyd III WN Suki G Eknoyan 1982 Plasma acid-base patterns in diabetic ketoacidosis N Engl J Med 307 1603 1610
3. H Aebi 1984 Catalase, in vitro Methods Enzymol 105 121 126
4. MY Aksenov WR Markesbery 2001 Change in thiol content and expression of glutathione redox system gene in the hippocampus and cerebellum in Alzheimer's disease Neurosci Lett 302 141 145
5. PS Brookes Y Yoon JL Robotham MW Anders SS Sheu 2004 Calcium, ATP, and ROS: a mitochondrial love-hate triangle Am J Physiol Cell Physiol 287 C817 C833
6. RW Browne D Armstrong 1998 Reduced glutathione and glutathione disulfide Methods Mol Biol 108 347 352
7. H Esterbauer KH Cheeseman 1990 Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal Methods Enzymol 186 407 421
8. P Evelson M Travacio M Repetto J Escobar S Llesuy E Lissi 2001 Evaluation of total reactive antioxidant potential (TRAP) of tissue homogenates and their cytosols Arch Biochem Biophyss 388 261 266
9. T Fukao H Shintaku R Kusubae GX Zhang K Nakamura M Kondo N Kondo 2004 Patients Homozygous for the T435N mutation of Succinyl-CoA: 3-Ketoacid CoA Transferase (SCOT) do not show permanent ketosis Pediatr Res 56 858 863
10. DL Gilbert PL Pyzik JM Freeman 2000 The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones J Child Neurol 15 787 790
11. B Gonzalez-Flecha S Llesuy A Boveris 1991 Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver, and muscle Free Radic Biol Med 10 93 100
12. SK Jain 1989 Hyperglycemia can cause membrane lipid peroxidation and osmotic fragiliy in human red blood cells J Biol Chem 264 21340 21345
13. SK Jain R McVie 1999 Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients Diabetes 48 555 1850
14. SK Jain K Krishnaswamy G Lim 1998 Ketosis (acetoacetate) can generate oxygen radicals and cause increased lipid peroxidation and growth inhibition in human endothelial cells Free Radic Biol Med 25 1083 1088
15. SK Jain R McVie R Jackson SN Levine G Lim 1999 Effect of hyperketonemia on plasma lipid peroxidation levels in diabetic patients Diabetes Care 22 1171 1175
16. SK Jain K Kannan G Lim J Matthew-Gree R Mc Vie JA Bocchini 2003 Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes Diabetes Care 26 2139 2143
17. SK Jain R McVie JA Bocchini Jr 2006 Hyperketonemia (ketosis), oxidative stress and type 1 diabetes Pathophysiology 13 163 170
18. Y Kashiwaya T Takeshima N Mori K Nakashima K Clarke RL Veech 2000 D-beta-hydroxybutyrate protects neurons in models of lzheimer's and Parkinson's disease Proc Natl Acad Sci USA 97 5440 5444
19. L Laffel 1999 Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes Diabetes Metab Res Rev 15 412 426
20. CP LeBel H Ischiropoulos SC Bondy 1992 Evaluation of the probe 2′,7′- dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress Chem Res Toxicol 5 227 231
21. DM Lee WH Hoffman GF Carl M Khichi PE Cornwell 2002 Lipid peroxidation and antioxidant vitamins prior to, during, and after correction of diabetic ketoacidosis J Diabetes Complicat 16 294 300
22. E Lissi M Salim-Hanna C Pascual MD del Castillo 1995 Evaluation of total antioxidant potential (TRAP) and total antioxidant reactivity from luminol-enhanced chemiluminescence measurements Free Radic Biol Med 18 153 158
23. OH Lowry NJ Rosebrough A Lewis-Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275
24. M Maalouf PG Sullivan L Davis DY Kim JM Rho 2007 Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation Neuroscience 145 256 264
25. L Massieu ML Haces T Montiel K Hernandez-Fonseca 2003 Acetoacetate protects hippocampal neurons against glutamate-mediated neuronal damage during glycolysis inhibition Neuroscience 120 365 378
26. GA Mitchell S Kassovska-Bratinova Y Boukaftane M-F Robert SP Wang L Ashmarina M Lambert 1995 Medical aspects of ketone body metabolism Clin Invest Med 18 193 216
27. Mitchell GA, Fukao TJC (2001) Inborn errors of ketone body metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease. McGraw-Hill, New York, pp 2340-2342
28. AAM Morris 2005 Cerebral ketones body metabolism J Inherit Metab Dis 28 109 121
29. R Natarajan RG Gerrity JL Gu L Lanting L Thomas JL Nadler 2002 Role of 12-lipoxygenase and oxidant stress in hyperglycaemia-induced acceleration of atherosclerosis in a diabetic pig model Diabetologia 45 125 133
30. KE Niezen-Koning RJA Wanders JPN Ruiter L Ijlst G Visser WCC Reitsma-Bierens HSA Heymans DJ Reijngoud GPA Smit 1997 Succinyl-CoA:acetoacetate transferase deficiency: identification of a new patient whit a neonatal onset and review of the literature Eur J Pediatr 156 870 873
31. T Nischikawa D Edelstein XL Du S Yamagishi T Matsumura Y Kaneda MA Yorek D Beebe PJ Oates HP Hammes I Giardino M Brownlee 2000 Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage Nature 404 787 790
32. OE Owen AP Morgan HG Kemp JM Sullivan MG Herrera GF Cahill Jr 1967 Brain metabolism during fasting J Clin Invest 46 1589 1595
33. P Rajeswari R Natarajan JL Nadler D Kumar 1991 Glucose induces lipid peroxidation and inactivation of membrane associated iron transport enzymes in human erythrocytes in vivo and in vitro J Cell Physiol 149 100 109
34. AZ Reznick L Packer 1994 Oxidative damage to proteins: spectrophotometric method for carbonyl assay Methods Enzymol 233 357 363
35. JE Squires J Sun JL Caffrey D Yoshishige RT Mallet 2003 Acetoacetate augments β-adrenergic inotropism of stunned myocardium by an antioxidant mechanism Am J Physiol Heart Circ Physiol 284 H1340 H1347
36. PG Sullivan NA Rippy K Dorenbos RC Concepcion AK Agarwal JM Rho 2004 The ketogenic diet increase mitochondrial uncoupling protein levels and activity Ann. Neurol. 55 576 580
37. M Suzuki K Sato S Dohi T Sato A Matsuura A Hairaide 2001 Effect of beta-hydroxybutyrate, a cerebral function improving agent, on cerebral hypoxia, anoxia and ischemia in mice and rats Jpn J Pharmacol 87 143 150
38. M Suzuki Y Kitamura S Mori K Sato S Dohi T Sato A Matsuura A Hairaide 2002 Beta-hydroxybutirate, a cerebral function improving agent, protects rat brain against ischemic damage caused by permanent and transient focal cerebral ischemia Jpn J Pharmacol 89 36 43
39. B Tesfamariam RA Cohen 1992 Free radicals mediate endothelial cell dysfunction caused by elevated glucose J Physiol 262 H321 H326
40. RL Veech B Chance Y Kashiwaya HA Lardy GF Cahill Jr 2001 Ketones bodies, potential therapeutic uses IUBMB Life 51 241 247
41. A Wendel 1981 Glutathione peroxidase Methods Enzymol l77 325 332