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1
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33645419526
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Molecular and cellular imaging of athero-sclerosis: Emerging applications
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Jaffer FA, Libby P, Weissleder R. Molecular and cellular imaging of athero-sclerosis: emerging applications. J Am Coll Cardiol 2006; 47:1328-1338.
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J Am Coll Cardiol
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Jaffer, F.A.1
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Weissleder, R.3
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Molecular imaging of cardiovascular disease
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Jaffer FA, Libby P, Weissleder R. Molecular imaging of cardiovascular disease. Circulation 2007; 116:1052-1061.
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(2007)
Circulation
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Jaffer, F.A.1
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39749198156
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Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008; 451:953-957. This recent comprehensive review of atherosclerosis imaging summarizes the currently available state-of-the-art technologies for clinical and preclinical noninvasive evaluation of atherosclerotic cardiovascular disease.
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Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008; 451:953-957. This recent comprehensive review of atherosclerosis imaging summarizes the currently available state-of-the-art technologies for clinical and preclinical noninvasive evaluation of atherosclerotic cardiovascular disease.
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4
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33646537848
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Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology
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Wickline SA, Neubauer AM, Winter P, et al. Applications of nanotechnology to atherosclerosis, thrombosis, and vascular biology. Arterioscler Thromb Vasc Biol 2006; 26:435-441.
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Arterioscler Thromb Vasc Biol
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Wickline, S.A.1
Neubauer, A.M.2
Winter, P.3
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6
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0037180771
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Inflammation in atherosclerosis
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Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868-874.
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Nature
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Libby, P.1
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7
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From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: part I
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Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 2003; 108:1664-1672.
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Circulation
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Naghavi, M.1
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8
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From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: part II
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Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part II. Circulation 2003; 108:1772-1778.
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Circulation
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Naghavi, M.1
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Hyafil F, Cornily JC, Feig JE, et al. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat Med 2007; 13:636-641. With the development of a novel positive-contrast CT molecular imaging agent that targets atherosclerotic inflammation, this work represents a major advance toward the goal of in-vivo coronary atherosclerotic plaque biological imaging. In concert with the anatomical and calcium scoring information already available by coronary CT, clinical translation of this agent may provide additional important data for coronary plaque risk stratification.
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Hyafil F, Cornily JC, Feig JE, et al. Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography. Nat Med 2007; 13:636-641. With the development of a novel positive-contrast CT molecular imaging agent that targets atherosclerotic inflammation, this work represents a major advance toward the goal of in-vivo coronary atherosclerotic plaque biological imaging. In concert with the anatomical and calcium scoring information already available by coronary CT, clinical translation of this agent may provide additional important data for coronary plaque risk stratification.
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10
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0038179627
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Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging
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Kooi ME, Cappendijk VC, Cleutjens KB, et al. Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging. Circulation 2003; 107:2453-2458.
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Circulation
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Kooi, M.E.1
Cappendijk, V.C.2
Cleutjens, K.B.3
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11
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33748349225
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Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI
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Tang T, Howarth SP, Miller SR, et al. Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke 2006; 37:2266-2270.
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Stroke
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Tang, T.1
Howarth, S.P.2
Miller, S.R.3
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12
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3042637502
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In vivo detection of macrophages in human carotid atherama: Temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI
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Trivedi RA, U-King-Im JM, Graves MJ, et al. In vivo detection of macrophages in human carotid atherama: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI. Stroke 2004; 35:1631-1635.
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Stroke
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Trivedi, R.A.1
U-King-Im, J.M.2
Graves, M.J.3
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13
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47649104588
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Correlation of carotid atheromatous plaque inflammation using USPIO-Enhanced MR imaging with degree of luminal stenosis
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This clinical study of patients with asymptomatic carotid stenosis who underwent USPIO-enhanced MRI reveals that the amount of carotid plaque inflammation appears to be independent of the severity of stenosis
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Tang TY, Howarth SP, Miller SR, et al. Correlation of carotid atheromatous plaque inflammation using USPIO-Enhanced MR imaging with degree of luminal stenosis. Stroke 2008; 39:2144-2147. This clinical study of patients with asymptomatic carotid stenosis who underwent USPIO-enhanced MRI reveals that the amount of carotid plaque inflammation appears to be independent of the severity of stenosis.
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(2008)
Stroke
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Tang, T.Y.1
Howarth, S.P.2
Miller, S.R.3
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American College of Cardiology Scientific Sessions; 29 March-1 April, Chicago, Illinois;
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Tang TY, Miller SR, Graves MJ, et al. Effects of Aggressive versus conventional lipid-lowering therapy by atorvastatin on inflammatory activity in human carotid atherosclerotic plaques: a prospective randomized double-blind trial with USPIO-enhanced high resolution magnetic resonance imaging. American College of Cardiology Scientific Sessions; 29 March-1 April 2008; Chicago, Illinois; 2008:6. http://acc08.acc.org/Documents/ACC%20D4.pdf.
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Effects of Aggressive versus conventional lipid-lowering therapy by atorvastatin on inflammatory activity in human carotid atherosclerotic plaques: A prospective randomized double-blind trial with USPIO-enhanced high resolution magnetic resonance imaging
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Tang, T.Y.1
Miller, S.R.2
Graves, M.J.3
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15
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38549156318
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p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of athero-sclerosis: MRI assessment
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This study demonstrates that, in a murine atherosclerosis model, anti-inflammatory treatment with a p38 MAPK inhibitor abrogates evidence of atherosclerotic plaque inflammation
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Morris JB, Olzinski AR, Bernard RE, et al. p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of athero-sclerosis: MRI assessment. Arterioscler Thromb Vasc Biol 2008; 28:265-271. This study demonstrates that, in a murine atherosclerosis model, anti-inflammatory treatment with a p38 MAPK inhibitor abrogates evidence of atherosclerotic plaque inflammation.
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(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 265-271
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Morris, J.B.1
Olzinski, A.R.2
Bernard, R.E.3
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16
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33846499213
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Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI
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Development and testing of a novel gadolinium-containing immunomicelle that targets the macrophage scavenger receptor for MRI-based evaluation of athero-sclerotic plaque inflammation
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Amirbekian V, Lipinski MJ, Briley-Saebo KC, et al. Detecting and assessing macrophages in vivo to evaluate atherosclerosis noninvasively using molecular MRI. Proc Natl Acad Sci U S A 2007; 104:961-966. Development and testing of a novel gadolinium-containing immunomicelle that targets the macrophage scavenger receptor for MRI-based evaluation of athero-sclerotic plaque inflammation.
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Proc Natl Acad Sci U S A
, vol.104
, pp. 961-966
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Amirbekian, V.1
Lipinski, M.J.2
Briley-Saebo, K.C.3
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17
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38349158417
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Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
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This significant work validates a versatile nanoparticle contrast agent for macrophage plaque detection that can be used with three imaging modalities PET, MRI, NIRF
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Nahrendorf M, Zhang H, Hembrador S, et al. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation 2008; 117:379-387. This significant work validates a versatile nanoparticle contrast agent for macrophage plaque detection that can be used with three imaging modalities (PET, MRI, NIRF).
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(2008)
Circulation
, vol.117
, pp. 379-387
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Nahrendorf, M.1
Zhang, H.2
Hembrador, S.3
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18
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33645380891
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Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials
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Jaffer FA, Nahrendorf M, Sosnovik D, et al. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging 2006; 5:85-92.
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(2006)
Mol Imaging
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Jaffer, F.A.1
Nahrendorf, M.2
Sosnovik, D.3
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19
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38349114229
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Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions
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, mice to track monocyte recruitment to atherosclerotic plaques in vivo
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-/- mice to track monocyte recruitment to atherosclerotic plaques in vivo.
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(2008)
Circulation
, vol.117
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Kircher, M.F.1
Grimm, J.2
Swirski, F.K.3
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20
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33947517527
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Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: Results of the ARMYDA-ACS randomized trial
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Patti G, Pasceri V, Colonna G, et al. Atorvastatin pretreatment improves outcomes in patients with acute coronary syndromes undergoing early percutaneous coronary intervention: results of the ARMYDA-ACS randomized trial. J Am Coll Cardiol 2007; 49:1272-1278.
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J Am Coll Cardiol
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Patti, G.1
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Colonna, G.3
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21
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Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography
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Rudd JH, Warburton EA, Fryer TD, et al. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105:2708-2711.
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Circulation
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Rudd, J.H.1
Warburton, E.A.2
Fryer, T.D.3
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22
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In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients
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Tawakol A, Migrino RQ, Bashian GG, et al. In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. J Am Coll Cardiol 2006; 48:1818-1824.
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J Am Coll Cardiol
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Tawakol, A.1
Migrino, R.Q.2
Bashian, G.G.3
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23
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34548748759
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The prevalence of inflammation in carotid atherosclerosis: Analysis with fluorodeoxyglucose-positron emission tomography
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18FDG-PET
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18FDG-PET.
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(2007)
Eur Heart J
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Tahara, N.1
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24
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34047179905
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Vascular inflammation evaluated by [18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome
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18FDG-PET, radiotracer uptake in carotid atheromas positively correlates with components of the metabolic syndrome
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18FDG-PET, radiotracer uptake in carotid atheromas positively correlates with components of the metabolic syndrome.
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(2007)
J Am Coll Cardiol
, vol.49
, pp. 1533-1539
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Tahara, N.1
Kai, H.2
Yamagishi, S.3
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25
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(18) Fluorodeoxyglucose positron emission tomography imaging of atherosclerotic plaque inflammation is highly reproducible: Implications for atherosclerosis therapy trials
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13FDG-PET atherosclerosis imaging as a highly reproducible technique
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13FDG-PET atherosclerosis imaging as a highly reproducible technique.
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(2007)
J Am Coll Cardiol
, vol.50
, pp. 892-896
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Rudd, J.H.1
Myers, K.S.2
Bansilal, S.3
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26
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33750448287
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Simvastatin attenuates plaque inflammation: Evaluation by fluorodeoxyglucose positron emission tomography
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Tahara N, Kai H, Ishibashi M, et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006; 48:1825-1831.
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J Am Coll Cardiol
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Tahara, N.1
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Ishibashi, M.3
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27
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55149095146
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Available on World Wide Web URL
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ClinicalTrials.gov. Available on World Wide Web URL: http:// clinicaltrials.gov/ct2/results?term=FDG+atherosclerosis.
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28
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14044276313
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Detection of vascular adhesion molecule-1 expression using anovel multimodal nanoparticle
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Kelly KA, Allport JR, Tsourkas A, et al. Detection of vascular adhesion molecule-1 expression using anovel multimodal nanoparticle. Circ Res 2005; 96:327-336.
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Circ Res
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Kelly, K.A.1
Allport, J.R.2
Tsourkas, A.3
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29
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Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in athero-sclerosis
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Nahrendorf M, Jaffer FA, Kelly KA, et al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in athero-sclerosis. Circulation 2006; 114:1504-1511.
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(2006)
Circulation
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Nahrendorf, M.1
Jaffer, F.A.2
Kelly, K.A.3
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30
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34547580851
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Kaufmann BA, Sanders JM, Davis C, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation 2007; 116:276-284. This work demonstrates the identification of early markers of endothelial activation in vivo with contrast-enhanced ultrasound providing a tool for noninvasive assessment of vascular inflammation.
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Kaufmann BA, Sanders JM, Davis C, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation 2007; 116:276-284. This work demonstrates the identification of early markers of endothelial activation in vivo with contrast-enhanced ultrasound providing a tool for noninvasive assessment of vascular inflammation.
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31
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0037062686
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In vivo imaging of proteolytic activity in atherosclerosis
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Chen J, Tung CH, Mahmood U, et al. In vivo imaging of proteolytic activity in atherosclerosis. Circulation 2002; 105:2766-2771.
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(2002)
Circulation
, vol.105
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Chen, J.1
Tung, C.H.2
Mahmood, U.3
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32
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27444439210
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Matrix metalloproteinase-13/ collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques
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Deguchi JO, Aikawa E, Libby P, et al. Matrix metalloproteinase-13/ collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation 2005; 112:2708-2715.
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(2005)
Circulation
, vol.112
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Deguchi, J.O.1
Aikawa, E.2
Libby, P.3
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33
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0036846990
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In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
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Jaffer FA, Tung CH, Gerszten RE, et al. In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe. Arterioscler Thromb Vasc Biol 2002; 22:1929-1935.
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(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 1929-1935
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Jaffer, F.A.1
Tung, C.H.2
Gerszten, R.E.3
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34
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0032951071
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In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
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Weissleder R, Tung CH, Mahmood U, et al. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999; 17:375-378.
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Nat Biotechnol
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Weissleder, R.1
Tung, C.H.2
Mahmood, U.3
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35
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34247575810
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Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor
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This study represents a major advance in the application of in-vivo biological imaging with the development of a novel pratease-acth/atable NIRF molecular agent able to identify potentially destabilizing enzyme activity in atherosclerotic plaques
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Jaffer FA, Kim DE, Quinti L, et al. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation 2007; 115:2292-2298. This study represents a major advance in the application of in-vivo biological imaging with the development of a novel pratease-acth/atable NIRF molecular agent able to identify potentially destabilizing enzyme activity in atherosclerotic plaques.
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(2007)
Circulation
, vol.115
, pp. 2292-2298
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Jaffer, F.A.1
Kim, D.E.2
Quinti, L.3
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36
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40749151108
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Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach
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This article reports on a new gadolinium-based MRI contrast agent that has increased affinity for MMP-rich atherosclerotic plaques
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Lancelot E, Amirbekian V, Brigger I, et al. Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach. Arterioscler Thromb Vasc Biol 2008; 28:425-432. This article reports on a new gadolinium-based MRI contrast agent that has increased affinity for MMP-rich atherosclerotic plaques.
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(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 425-432
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Lancelot, E.1
Amirbekian, V.2
Brigger, I.3
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37
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1842483342
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Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis
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Kietselaer BL, Reutelingsperger CP, Heidendal GA, et al. Noninvasive detection of plaque instability with use of radiolabeled annexin A5 in patients with carotid-artery atherosclerosis. N Engl J Med 2004; 350:1472-1473.
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N Engl J Med
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Kietselaer, B.L.1
Reutelingsperger, C.P.2
Heidendal, G.A.3
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38
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36549066781
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Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging
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This study demonstrates a novel nuclear imaging molecular probe for detection of macrophage apoptosis in hyperchotesterolemic rabbits
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Sarai M, Hartung D, Petrov A, et al. Broad and specific caspase inhibitor-induced acute repression of apoptosis in atherosclerotic lesions evaluated by radiolabeled annexin A5 imaging. J Am Coll Cardiol 2007; 50:2305-2312. This study demonstrates a novel nuclear imaging molecular probe for detection of macrophage apoptosis in hyperchotesterolemic rabbits.
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(2007)
J Am Coll Cardiol
, vol.50
, pp. 2305-2312
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Sarai, M.1
Hartung, D.2
Petrov, A.3
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39
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37349065459
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Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo
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This interesting work elegantly defines a new NIRF approach that has the ability to demarcate early plaque osteogenesis before it becomes histologically evident, and provides compelling evidence that macrophage infiltration and inflammation are key predisposing factors in this process
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Aikawa E, Nahrendorf M, Figueiredo JL, et al. Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo. Circulation 2007; 116:2841-2850. This interesting work elegantly defines a new NIRF approach that has the ability to demarcate early plaque osteogenesis before it becomes histologically evident, and provides compelling evidence that macrophage infiltration and inflammation are key predisposing factors in this process.
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(2007)
Circulation
, vol.116
, pp. 2841-2850
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Aikawa, E.1
Nahrendorf, M.2
Figueiredo, J.L.3
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