Heme pocket architecture in human serum albumin: Regulation of O 2 binding affinity of a prosthetic heme group by site-directed mutagenesis

Macromolecular Symposia

Volumn 270, Issue 1, 2008, Pages 187-192

  Komatsu, Teruyuki ^a,b   Nakagawa, Akito ^a   Tsuchida, Eishun ^a  

^a WASEDA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Biomimetics; Heme; Human seruma albumin; O2 binidng; Proteins

Indexed keywords

ANIMAL CELL CULTURE; BINDING ENERGY; BINDING SITES; BIOMIMETICS; BLOOD; BODY FLUIDS; COORDINATION REACTIONS; DISSOCIATION; DYES; IRON; IRON COMPOUNDS; MUTAGENESIS; PHOTOLYSIS; PLANTS (BOTANY); PORPHYRINS; PROSTHETICS; RATE CONSTANTS;

AXIAL COORDINATIONS; AXIAL LIGATIONS; BINDING AFFINITIES; BINDING CAPABILITIES; BINDING PROPERTIES; DIFFERENT GEOMETRIES; DISSOCIATION RATE CONSTANTS; DOUBLE MUTANTS; GREAT-ER; HEME; HEME POCKETS; HEMOPROTEIN; HUMAN RED BLOOD CELLS; HUMAN SERUM ALBUMINS; HUMAN SERUMA ALBUMIN; HYDROPHOBIC; IRONPROTOPORPHYRIN; LASER FLASHES; MONOPHASIC KINETICS; O2 BINIDNG; PROSTHETIC HEME GROUPS; PROTOPORPHYRIN; PROXIMAL; RECOMBINANT HUMAN SERUM ALBUMIN (RHSA); RECOMBINATION PROCESSES; ROOM TEMPERATURES; SITEDIRECTED MUTAGENESISES; SUBDOMAIN;

HEMOGLOBIN;

EID: 55049094898     PISSN: 10221360     EISSN: 15213900     Source Type: Journal    
DOI: 10.1002/masy.200851022     Document Type: Conference Paper

References (26)

1. T. Peters, Jr., "All about Albumin, Biochemistry, Genetics and Medical Applications", Academic Press, San Diego 1997.
2. [23] U. Kragh-Hansen, Pharmacol. Rev, 1981, 33, 17;
3. [2b] U. Kragh-Hansen, Danish Med. Bull. 1990, 37, 57.
4. [33] S. Curry, H. Madelkow, P. Brick, N. Franks, Nat. Struct. biol. 1998, 5, 827;
5. [3b] A. A. Bhattacharya, T. Grune, S. Curry, J. Mol. Biol. 2000, 303, 721.
6. J. Ghuman, P. A. Zunszain, I. Petipas, A. A. Bhattacharya, M. Otagiri, S. Curry, J. Mol. Biol.. 2005, 353, 38.
7. P. A. Adams, M. C. Berman, Biochem. J. 1980, 191, 95.
8. M. C. Warden, E. S. Hazard, L. Leclerc, Q. H. Gibson, Biochemistry 1989, 28, 4422.
9. T. Komatsu, Y. Matsukawa, E. Tsuchida, Bloconjugate Chem. 2002, 13, 397.
10. X. M. He, D. C. Carter, Nature 1992, 358, 209-215.
11. P. A. Zunszain, J. Ghuman, T. Komatsu, E. Tsuchida, S. Curry, BMC Struct. Biol. 2003, 3, 6.
12. M. Wardell, Z. Wang, J. X. Ho, J. Robert, F. Ruker, J. Rubel, D. C. Carter, Biochem. Biophys. Res. Commun. 2002, 291, 813.
13. [11a] T. Komatsu, N. Ohmichi, P. A. Zunszain, S. Curry, E. Tsuchida, J. Am. Chem. Soc. 2004, 126, 14304;
14. [11b] T. Komatsu, N. Ohmichi, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida, J. Am. Chem. Soc. 2005, 127, 15933.
15. L Vickery, T. Nozawa, K. Sauer, J. Am. Chem. Soc. 1976, 98, 343.
16. E. Antonini, M. Brunori, "Hemogiobin and Myoglobin in Their Reactions with Ligands", North-Holland Pub, Amsterdam 1971, pp 18.
17. T. G. Traylor, C. K. Chang, J. Geibel, A. Berzinis, T. Mincey, J. Cannon, J. Am. Chem. Soc. 1979, 101, 6716.
18. J. P. Collman, J. I. Brauman, B. L Iverson, J. L. Sessler, R. M. Moris, Q. H. Gibson, J. Am. Chem. Soc. 1983, 105, 3052.
19. T. G. Traylor, S. Tsuchiya, D. Campbell, M. Mitchel, D. Stynes, N. Koga, J. Am. Chem. Soc. 1985, 107, 604.
20. Q. H. Gibson, J. Blol. Chem. 1970, 245, 3285.
21. J. H. Oison, M. E. Andersen, Q. H. Gibson, J. Blol. Chem. 1971, 246, 5919.
22. R. Rohlfs, A. J. Mathews, T. E. Carver, J. S. Olson, B. A. Springer, K. D. Egeberg, S. G. Sliger, J. Biol. Chem. 1990, 265, 3168.
23. S. E. V. Phillips, B. P. Schoenborn, Nature 1981, 292, 81.
24. J. S. Oison, A. J. Mathews, R. J. Rohlfs, B. A. Springer, K. D. Egeberg, S. G. Sligar, J. Tame, J.-P. Renaud, K. Nagai, Nature 1988, 336, 365.
25. T. Komatsu, A. Nakagawa, P. A. Zunszain, S. Curry, E. Tsuchida, J. Am. Chem. Soc. 2007, 129, in press.
26. K. Imai, H. Morimoto, M. Kotani, H. Watari, W. Hirata, M. Kuroda, Biochim. Biphys. Acta. 1970, 200, 189.