PEGylated chitosan-based polymer micelle as an intracellular delivery carrier for anti-tumor targeting therapy

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 3, 2008, Pages 749-757

  Hu, Fu Qiang ^a   Meng, Pan ^a   Dai, You Qin ^b   Du, Yong Zhong ^a   You, Jian ^a   Wei, Xiao Hong ^a   Yuan, Hong ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NINGBO NO 2 HOSPITAL   (China)

Author keywords

Cellular uptake; Chitosan oligosaccharide; In vitro anti tumor activity; Macrophage; Micelle; Polyethylene glycol

Indexed keywords

CHITOSAN; DRUG CARRIER; MACROGOL; MITOMYCIN C; OLIGOSACCHARIDE; POLYMER; STEARIC ACID;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; DRUG DELIVERY SYSTEM; GROWTH INHIBITION; HUMAN; HUMAN CELL; MICELLE; NONHUMAN; PHYSICAL CHEMISTRY; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; HUMANS; INHIBITORY CONCENTRATION 50; LIVER; MACROPHAGES; MICE; MICELLES; MITOMYCIN; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; STEARIC ACIDS; TIME FACTORS;

EID: 54949141087     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.06.015     Document Type: Article

References (39)

1. Bae Y., Diezi T.A., Zhao A., and Kwon G.S. Mixed polymeric micelles for combination cancer chemotherapy through the concurrent delivery of multiple chemotherapeutic agents. J. Control. Release 122 (2007) 324-330
2. Minchinton A.I., and Tannock I.F. Drug penetration in solid tumours. Nat. Rev. Cancer 6 (2006) 583-592
3. Kano M.R., Bae Y., Iwata C., Morishita Y., Yashiro M., Oka M., Fujii T., Komuro A., Kiyono K., Kamiishi M., Hirakawa K., Ouchi Y., Nishiyama N., Kataoka K., and Miyazono K. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling. Proc. Natl. Acad. Sci. USA 104 (2007) 3460-3465
4. Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer 6 (2006) 688-701
5. Kopecek J., Kopeckova P., Minko T., and Lu Z.R. HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action. Eur. J. Pharm. Biopharm. 50 (2000) 61-81
6. Nishiyama N., and Kataoka K. Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery. Pharmacol. Ther. 112 (2006) 630-648
7. Lavasanifar A., Samue J., and Kwon G.S. Poly(ethylene oxide)-block-poly(l-amino acid) micelles for drug delivery. Adv. Drug Deliv. Rev. 54 (2002) 169-190
8. Kataoka K., Kwon G.S., Yokoyama M., Okano T., and Sakurai Y. Block copolymer micelles as vehicles for drug delivery. J. Control. Release 24 (1993) 119-132
9. Aliabadi H.M., Brocks D.R., and Afsaneh L. Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution. Biomaterials 26 (2005) 7251-7259
10. Kwon G.S. Polymeric micelles for delivery of poorly water-soluble compounds. Crit. Rev. Ther. Drug Carrier Syst. 20 (2003) 357-403
11. Li L.B., and Tan Y.B. Preparation and properties of mixed micelles made of pluronic polymer and PEG-PE. J. Colloid Interface Sci. 317 (2008) 326-331
12. Zabaleta V., Campanero M.A., and Irache J.M. An HPLC with evaporative light scattering detection method for the quantification of PEGs and Gantrez in PEGylated nanoparticles. J. Pharm. Biomed. 44 (2007) 1072-1078
13. Jiang X., Dai H., Leong K.W., Goh S.H., Mao H.Q., and Yang Y.Y. Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions. J. Gene Med. 8 (2006) 477-487
14. Gao J.Q., Eto Y., Yoshioka Y., Sekiguchi F., Kurachi S., Morishige T., Yao X.L., Watanabe H., Asavatanabodee R., Sakurai F., Mizuguchi H., Okada Y., Mukai Y., Tsutsumi Y., Mayumi T., Okada N., and Nakagawa S. Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J. Control. Release 122 (2007) 102-110
15. Tsutsumi Y., Tsunoda S., Kaneda Y., Kamada H., Kihira T., Nakagawa S., Yamamoto Y., Horisawa Y., and Mayumi T. In vivo anti-tumor efficacy of polyethylene glycol-modified tumor necrosis factor-alpha against tumor necrosis factor-resistant tumors. Jpn. J. Cancer Res. 87 (1996) 1078-1085
16. Shibata H., Yoshioka Y., Ikemizu S., Kobayashi K., Yamamoto Y., Mukai Y., Okamoto T., Taniai M., Kawamura M., Abe Y., Nakagawa S., Hayakawa T., Nagata S., Yamagata Y., Mayumi T., Kamada H., and Tsutsumi Y. Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin. Cancer Res. 10 (2004) 8293-8300
17. Inada Y., Furukawa M., Sasaki H., Kodera Y., Hiroto M., Nishimura H., and Matsushima A. Biomedical and biotechnological applications of PEG- and PM-modified proteins. Trends Biotechnol. 13 (1995) 86-91
18. Zhou R., Mazurchuk R., and Straubinger R.M. Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model. Cancer Res. 62 (2002) 2561-2566
19. Terada T., Mizobata M., Kawakami S., Yamashita F., and Hashida M. Optimization of tumor-selective targeting by basic fibroblast growth factor-binding peptide grafted PEGylated liposomes. J. Control. Release 119 (2007) 262-270
20. Patel H.M. Serum opsonins and liposomes: their interaction and opsonophagocytosis. Crit. Rev. Ther. Drug Carrier Syst. 9 (1992) 39-90
21. Hong J.W., Park J.H., Huh K.M., Chung H., Kwon I.C., and Jeong S.Y. PEGylated polyethylenimine for in vivo local gene delivery based on lipiodolized emulsion system. J. Control. Release 99 (2004) 167-176
22. Wang Y., Ke C.Y., Beh C.W., Liu S.Q., Goh S.H., and Yang Y.Y. The self-assembly of biodegradable cationic polymer micelles as vectors for gene transfection. Biomaterials 28 (2007) 5358-5368
23. Hu F.Q., Ren G.F., Yuan H., Du Y.Z., and Zeng S. Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel. Colloids Surf. B Biointerfaces 50 (2006) 97-103
24. Hu F.Q., Zhao M.D., Yuan H., You J., Du Y.Z., and Zeng S. A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies. Int. J. Pharm. 315 (2006) 158-166
25. You J., Hu F.Q., Du Y.Z., and Yuan H. Polymeric micelles with glycolipid-like structure and multiple hydrophobic domains for mediating-target delivery of paclitaxel. Biomacromolecules 8 (2007) 2450-2456
26. You J., Hu F.Q., Du Y.Z., Yuan H., and Ye B.F. High cytotoxicity and resistant-cell reversal of novel paclitaxel loaded micelles by enhancing molecular-target delivery of the drug. Nanotechnology 18 (2007) 495101
27. Molina-Boli{dotless}́var J.A., Hierrezuelo J.M., and Carnero Ruiz C. Self-assembly, hydration, and structures in N-decanoyl-N-methylglucamide aqueous solutions: effect of salt addition and temperature. J. Colloid Interface Sci. 313 (2007) 656-664
28. Hegde V.L., and Venkatesh Y.P. Generation of antibodies specific to d-mannitol, a unique haptenic allergen, using reductively aminated d-mannose-bovine serum albumin conjugate as the immunogen. Immunobiology 212 (2007) 119-128
29. Li W.J., and Su Z.G. Quantitatively investigating monomethoxypolyethylene glycol modification of protein by capillary electrophoresis. J. Biochem. Biophys. Methods 59 (2004) 65-74
30. Ahmad J., Ashok B.T., and Ali R. Detection of oxidative DNA damage by a monoclonal antibody: role of lysyl residues in antigen binding. Immunol. Lett. 62 (1998) 87-92
31. Lee K.Y., and Jo W.H. Structural determination and interior polarity of self-aggregates prepared from deoxycholic acid-modified chitosan in water. Macromolecules 31 (1998) 378-383
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 (1983) 55-63
33. Eliyahua H., Joseph A., Schillemans J.P., Azzam T., Domb A.J., and Barenholz Y. Characterization and in vivo performance of dextran-sperminepolyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials 28 (2007) 2339-2349
34. Bilensoy E., G̈urkaynak O., Lale Doǧan A., and Hi{dotless}ncal A.A. Safety and efficacy of amphiphilic ß-cyclodextrin nanoparticles for paclitaxel delivery. Int. J. Pharm. 347 (2008) 163-170
35. Montasser I., Fessi H., and Coleman A.W. Atomic force microscopy imaging of novel type of polymeric colloidal nanostructures. Eur. J. Pharm. Biopharm. 54 (2002) 281-284
36. Chen W., Chen H.R., Hu J.H., Yang W.L., and Wang C.C. Synthesis and characterization of polyion complex micelles between poly(ethylene glycol)-grafted poly(aspartic acid) and cetyltrimethyl ammonium bromide. Colloids Surf. A Physicochem. Eng. Aspects 278 (2006) 60-66
37. Riess G. Micellization of block copolymers. Prog. Polym. Sci. 28 (2003) 1107-1170
38. Hussain S.M., Hess K.L., Gearhart J.M., Geiss K.T., and Schlager J.J. In vitro toxicity of nanoparticles in BRL-3A rat liver cells. Toxicol. In Vitro 19 (2005) 975-983
39. Storm G., Belliot S.O., Daemen T., and Lasic D.D. Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Adv. Drug Deliv. Rev. 17 (1995) 31-48