Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects

International Journal of Biological Sciences

Volumn 4, Issue 6, 2008, Pages 362-367

  Vasudevan, R ^a   Ismail, Patimah ^a   Stanslas, Johnson ^a   Shamsudin, Norashikin ^b   Ali, Aisyah Binti ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b Faculty of Science   (Malaysia)

Author keywords

Alpha2B adrenoceptor; Essential hypertension; Insertion deletion polymorphism; Type 2 diabetes mellitus

Indexed keywords

ALPHA 2B ADRENERGIC RECEPTOR;

ALLELE; ARTICLE; BODY MASS; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALAYSIA; NON INSULIN DEPENDENT DIABETES MELLITUS; SYSTOLIC BLOOD PRESSURE;

EID: 54949128281     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.4.362     Document Type: Article

References (25)

1. Rampal L, Rampal S, Azharc MZ, et al. Prevalence, awareness, treatment and control of hypertension in Malaysia: A national study of 16,440 subjects. Public Health 2008;122:11-8.
2. Lim TO, Morad Z. Prevalence, awareness, treatment and control of hypertension in the Malaysian adult population: results from the national health and morbidity survey 1996. Singapore Med J. 2004; 45:20-27.
3. Kohara K, Tabara Y, Nakura J, et al. Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the Millennium Genome Project for Hypertension. Hypertens Res. 2008; 31:203-212.
4. Agarwal A, Williams GH, Fisher ND. Genetics of human hypertension. Trends Endocrinol Metab. 2005;16:127-33.
5. Von Wowern F, Bengtsson K, Lindblad U, et al. Functional Variant in the 2B Adrenoceptor Gene, a Positional Candidate on Chromosome 2, Associates With Hypertension. Hypertension. 2004;43:592-7.
6. Lockette W, Ghosh S, Farrow S, et al. Alpha 2-adrenergic receptor gene polymorphism and hypertension in blacks. Am J Hypertens. 1995;8(4):390-4.
7. Snapir A, Heinonen P, Tuomainen TP, et al. An insertion/deletion polymorphism in the alpha2B-adrenergic receptor gene is a novel genetic risk factor for acute coronary events. J Am Coll Cardiol. 2001;37(6):1516-22.
8. Small KM, Brown KM, Forbes SL, et al. Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase mediated phosphorylation and desensitization. J Biol Chem. 2001;276:4917-2.
9. Siitonen N, Lindström J, Eriksson J, et al. Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study. Diabetologia. 2004;47(8):1416-24.
10. Snapir A, Scheinin M, Groop LC, et al. The insertion/deletion variation in the ?2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes. Cardiovasc Diabetol. 2003;24:2-15.
11. Ueno LM, Frazzatto ES, Batalha LT, et al. Alpha2B-adrenergic receptor deletion polymorphism and cardiac autonomic nervous system responses to exercise in obese women. Int J Obes (Lond). 2006;30(2):214-20.
12. Papazoglou D, Papanas N, Papatheodorou K, et al. An insertion/deletion polymorphism in the alpha2B adrenoceptor gene is associated with age at onset of type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2006;114(8):424-7.
13. Zhang H, Li X, Huang J, et al. Cardiovascular and metabolic phenotypes in relation to the ADRA2B insertion/deletion polymorphism in a Chinese population. J Hypertens. 2005;23(12):2201-7.
14. Jousilahti P, Tuomilehto J, Vartiainen E, et al. Body weight, cardiovascular risk factors, and coronary mortality - 15-year follow-up of middle-aged men and women in eastern Finland. Circulation. 1996;93:1372-9.
15. Sivenius K, Lindi V, Niskanen L, et al. Effect of a three-amino acid deletion in the alpha2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects. Int J Obes Relat Metab Disord. 2001;25(11):1609-14.
16. Heinonen P, Pettersson-Fernholm K, Forsblom C, et al. A deletion polymorphism of the alpha2B-adrenergic receptor gene is not associated with late complications in Type 1 diabetic patients. Diabet Med. 2005;22(2):226-8.
17. Baldwin CT, Schwartz F, Baima J, et al. Identification of a polymorphic glutamic acid stretch in the alpha2B-adrenergic receptor and lack of linkage with essential hypertension. Am J Hypertens. 1999;12(9):853-7.
18. Friedewald, WT, Levy RI, Fredrickson DS. Estimation of low density lipoprotein cholesterol without the use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-2.
19. Lomasney JW, Lorenz W, Allen LF, et al. Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2. Proc Natl Acad Sci USA. 1990;87(13):5094-8.
20. Heinonen P, Koulu M, Pesonen U, et al. Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects. J Clin Endocrinol Metab. 1999;84(7):2429-33.
21. Ruffolo RR Jr, Nichols AJ, Stadel JM, et al. Pharmacologic and therapeutic applications of alpha 2-adrenoceptor subtypes. Annu Rev Pharmacol Toxicol. 1993;33:243-9
22. Philipp M, Brede M, Hein L. Physiological significance of alpha (2)-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol. 2003;283:287-95.
23. Suzuki N, Matsunaga T, Nagasumi K, et al. Alpha(2B)-adrenergic receptor deletion polymorphism associates with autonomic nervous system activity in young healthy Japanese. J Clin Endocrinol Metab. 2003;88:1184-7.
24. Kable JW, Murrin LC, Bylund DB. In vivo gene modification elucidates subtype-specific functions of alpha 2-adrenergic receptors. J Pharmacol Exp Ther. 2000;293:1-7.
25. Beevers G, Lip GY, O'Brien E. ABC of hypertension: The pathophysiology of hypertension. BMJ. 2001; 322(7291):912-6.