Type 2 diabetes mellitus: A high-risk condition for cardiovascular disease irrespective of the different degrees of obesity

QJM: An International Journal of Medicine

Volumn 101, Issue 11, 2008, Pages 875-879

  Song, Soon H ^a   Hardisty, C A ^b  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL OBESITY; ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DYSLIPIDEMIA; HIGH RISK PATIENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OBSERVATIONAL STUDY; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR;

EID: 54949127565     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcn109     Document Type: Article

References (21)

1. The Look AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes; one-year results of the Look AHEAD trial. Diabetes Care 2007; 30 1374-83.
2. Ridderstrale M, Gudbjorndottir S, Eliason B, Nilsson PM, Cederholm J. Obesity and cardiovascular risk factors in type 2 diabetes: Results from the Swedish National Diabetes Register. J Intern Med 2006; 259 314-22.
3. Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH, Pinkney JH. Prevalence of obesity in type 2 diabetes in secondary care: Association with cardiovascular risk factors. Postgrad Med J 2006; 82 280-4.
4. Ezenwaka CE, Offiah NV. Cardiovascular risk in obese and nonobese patients with type 2 diabetes in the West Indies. J Biomed Sci 2001; 8:314-20.
5. Bo S, Gentile L, Cavallo-Perin P, Vineis P, Ghia V. Sex and BMI-related differences in risk factors for coronary artery disease in patients with type 2 diabetes mellitus. Acta Diabetol 1999; 36:147-53.
6. Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and risk of myocardial infarction in 27,000 participants from 52 countries. A case control study. Lancet 2005; 366:1640-9.
7. Saydah SH, Fradkin J, Cowle CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 2004; 291:335-42.
8. Klein R, Klein BEK, Moss SE. Is obesity related to microvascular and macrovascular complications in diabetes? The Wisconsin Epidemiological Study of Diabetic Retinopathy. Arch Intern Med 1997; 157 650-6.
9. Ong CR, Molyneaux LM, Constantino MI, Twigg SM, Yue DK. Long-term efficacy of metformin therapy in nonobese individuals with type 2 diabetes. Diabetes Care 2006; 29:2361-4.
10. Turner RC, Millns H, Holman RR. Coronary heart disease and risk factors in NIDDM - experience from the United Kingdom Prospective Diabetes Study. Diabetologia 1997; 40:S121-2.
11. Ruderman NB, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes 1998; 47 699-713.
12. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444:881-7.
13. Nelson RG, Sievers ML, Knowler WC, Swinburn BA, Pettitt DJ, Saad MF, et al. Low incidence of fatal coronary heart disease in Pima Indians despite high prevalence of non-insulin-dependent diabetes mellitus. Circulation 1990; 81:987-95.
14. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352:854-65.
15. Donnelly LA, Doney ASF, Hattersley AT, Morris AD, Pearson ER. The effect of obesity on glycaemic response to metformin or sulphonylurea in type 2 diabetes. Diabet Med 2006; 23:128-33.
16. Basat O, Ucak S, Ozkurt H, Basak M, Seber S, Altuntas Y. Visceral adipose tissue as an indicator of insulin resistance in nonobese patients with new onset type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 2006; 114:58-62.
17. National Institute for Clinical Excellence. Obesity: Guidance on the Prevention, Identification, Assessment and Management of Overweight and Obesity in Adults and Children. London, National Institute for Clinical Excellence, 2006.
18. Lee S, Kuk JL, Davidson LE, Hudson R, Kilpatrick K, Graham TE, et al Exercise without weight loss is an effective strategy for obesity reduction in obese individuals with and without type 2 diabetes. J Appl Physiol 2005; 99:1220-5.
19. Janiszewski PM, Ross R. Physical activity in the treatment of obesity: beyond body weight reduction. Appl Physiol Nutr Metab 2007; 32 512-22.
20. Boule NG, Weisnagel SJ, Lakka TA, Tremblay A, Bergman RN, Rankinen T, et al. Effects of exercise training on glucose homeostasis: The HERITAGE Family Study. Diabetes Care 2005; 28:108-14.
21. Duncan GE, Perri MG, Theriaque DW, Hutson AD, Eckel RH, Stacpoole PW. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 2003; 26:557-62.