Behavioural and biochemical responses to morphine associated with its motivational properties are altered in adenosine A 2A receptor knockout mice

British Journal of Pharmacology

Volumn 155, Issue 5, 2008, Pages 757-766

  Castane A ^a,e   Wells, L ^b   Soria, G ^a,e   Hourani, S ^b   Ledent, C ^c   Kitchen, I ^b   Opacka Juffry, J ^d   Maldonado, R ^a   Valverde, O ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^d UNIVERSITY OF ROEHAMPTON   (United Kingdom)

^e INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

A 2A adenosine receptors; Knockout mice; Microdialysis; Morphine; Place conditioning; Reward

Indexed keywords

ADENOSINE A2A RECEPTOR; DOPAMINE; DRUG VEHICLE; MORPHINE; NALOXONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; AVERSIVE BEHAVIOR; BEHAVIOR; CONTROLLED STUDY; DRUG WITHDRAWAL; DYSPHORIA; HOT PLATE TEST; KNOCKOUT MOUSE; LOCOMOTION; MALE; MICRODIALYSIS; MORPHINE ADDICTION; MOTIVATION; MOUSE; NEUROCHEMISTRY; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; WILD TYPE;

ANIMALS; BEHAVIOR, ANIMAL; DOPAMINE; MALE; MICE; MICE, KNOCKOUT; MICRODIALYSIS; MORPHINE; MOTIVATION; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; PAIN THRESHOLD; RECEPTOR, ADENOSINE A2A;

EID: 54949107720     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.299     Document Type: Article

References (54)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl 2): S1-S209.
2. Arolfo MP, Yao L, Gordon AS, Diamond I, Janak PH (2004). Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcohol Clin Exp Res 28: 1308-1316.
3. Bailey A, Davis L, Lesscher HM, Kelly MD, Ledent C, Hourani SM et al. (2004). Enhanced morphine withdrawal and micro-opioid receptor G-protein coupling in A2A adenosine receptor KO mice. J Neurochem 88: 827-834.
4. Bailey A, Ledent C, Kelly M, Hourani SM, Kitchen I (2002). Changes in spinal delta and kappa opioid systems in mice deficient in the A2A receptor gene. J Neurosci 22: 9210-9220.
5. Barbaccia ML, Reggiani A, Spano PF, Trabucchi M (1981). Ethanol-induced changes of dopaminergic function in three strains of mice characterized by a different population of opiate receptors. Psychopharmacology 74: 260-262.
6. Berrendero F, Castañé A, Ledent C, Parmentier M, Maldonado R, Valverde O (2003). Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double KO mice. Eur J Neurosci 17: 315-324.
7. Berridge KC, Robinson TE (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev 28: 309-369.
8. Castañé A, Soria G, Ledent C, Maldonado R, Valverde O (2006). Attenuation of nicotine-induced rewarding effects in A2A knockout mice. Neuropharmacology 51: 631-640.
9. Chefer VI, Kieffer BL, Shippenberg TS (2003). Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-KO mice. Eur J Neurosci 18: 1915-1922.
10. Dassesse D, Massie A, Ferrari R, Ledent C, Parmentier M, Arckens L et al. (2001). Functional striatal hypodopaminergic activity in mice lacking adenosine A(2A) receptors. J Neurochem 78: 183-198.
11. Di Chiara G (2002). Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137: 75-114.
12. Di Chiara G, Imperato A (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85: 5274-5278.
13. Eddy NB, Leimbach D (1953). Synthetic analgesics. II. Dithienylbutenyl-and dithienylbutylamines. J Pharmacol Exp Ther 107: 385-393.
14. Fadda P, Scherma M, Collu M, Fratta W (2005). Dopamine and serotonin release in dorsal striatum and nucleus accumbens is differentially modulated by morphine in DBA/2J and C57BL/6J mice. Synapse 56: 29-38.
15. Ferré S, Diamond I, Goldberg SR, Yao L, Hourani SMO, Huang ZL et al. (2007). Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry. Implications for drug addiction, sleep and pain. Prog Neurobiol 83: 332-347.
16. Ferré S, Fredholm BB, Morelli M, Popoli P, Fuxe K (1997). Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci 20: 482-487.
17. Fink JS, Weaver DR, Rivkees SA, Peterfreund RA, Pollack AE, Adler EM et al. (1992). Molecular cloning of the rat A2 adenosine receptor: selective co-expression with D2 dopamine receptors in rat striatum. Brain Res Mol Brain Res 14: 186-195.
18. Franco R, Ferré S, Agnati L, Torvinen M, Gines S, Hillion J et al. (2000). Evidence for adenosine/dopamine receptor interactions: indications for heteromerization. Neuropsychopharmacology 23: S50-S59.
19. Fredholm BB, Chen JF, Cunha RA, Svenningsson P, Vaugeois JM (2005). Adenosine and brain function. Int Rev Neurobiol 63: 191-270.
20. Gibaldi M, Perrier D (1975). The trapezoid rule. In: Gibaldi M, Perier D (eds). Pharmacokinetics, 2nd edn. Dekker, New York, pp 494.
21. Gupta ML, Nath R, Gupta TK, Gupta GP (1988). A study of central neurotransmitter mechanisms in morphine-induced 'Straub reaction' in mice: role of central dopamine receptors. Clin Exp Pharmacol Physiol 15: 727-732.
22. Hack SP, Christie MJ (2003). Adaptations in adenosine signaling in drug dependence: therapeutic implications. Crit Rev Neurobiol 15: 235-274.
23. He M, Shippenberg TS (2000). Strain differences in basal and cocaine-evoked dopamine dynamics in mouse striatum. J Pharmacol Exp Ther 293: 121-127.
24. Johnson SW, North RA (1992). Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J Physiology 450: 455-468.
25. Kaplan GB, Coyle TS (1998). Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation. Eur J Pharmacol 362: 1-8.
26. Kaplan GB, Sears MT (1996). Adenosine receptor agonists attenuate and adenosine receptor antagonists exacerbate opiate withdrawal signs. Psychopharmacology 123: 64-70.
27. Khalili M, Semnanian S, Fathollahi Y (2001). Caffeine increases paragigantocellularis neuronal firing rate and induces withdrawal signs in morphine-dependent rats. Eur J Pharmacol 412: 239-245.
28. Koob GF (1996). Hedonic valence, dopamine and motivation. Mol Psychiatry 1: 186-189.
29. Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ et al. (1997). Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor. Nature 388: 674-678.
30. Maldonado R, Saiardi A, Valverde O, Samad TA, Roques BP, Borrelli E (1997). Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature 388: 586-589.
31. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I et al. (1996). Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383: 819-823.
32. Moreau JL, Huber G (1999). Central adenosine A(2A) receptors: an overview. Brain Res Brain Res Rev 31: 65-82.
33. Rasmussen K, Aghajanian GK (1989). Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Res 505: 346-350.
34. Rethy CR, Smith CB, Villarreal JE (1971). Effects of narcotic analgesics upon the locomotor activity and brain catecholamine content of the mouse. J Pharmacol Exp Ther 176: 472-479.
35. Salamone JD (1996). The behavioral neurochemistry of motivation: methodological and conceptual issues in studies of the dynamic activity of nucleus accumbens dopamine. J Neurosci Methods 64: 137-149.
36. Salem A, Hope W (1997). Effect of adenosine receptor agonists and antagonists on the expression of opiate withdrawal in rats. Pharmacol Biochem Behav 57: 671-679.
37. Schiffmann SN, Vanderhaeghen JJ (1993). Adenosine A2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J Neurosci 13: 1080-1087.
38. Simonin F, Valverde O, Smadja C, Slowe S, Kitchen I, Dierich A et al. (1998). Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal. EMBO J 17: 886-897.
39. Shoaib M, Spanagel R, Stohr T, Shippenberg TS (1995). Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. Psychopharmacology 117: 240-247.
40. Short JL, Drago J, Lawrence AJ (2006). Comparison of ethanol preference and neurochemical measures of mesolimbic dopamine and adenosine systems across different strains of mice. Alcohol Clin Exp Res 30: 606-620.
41. Spanagel R, Weiss F (1999). The dopamine hypothesis of reward: past and current status. Trends Neurosci 22: 521-527.
42. Soria G, Castañé A, Berrendero F, Ledent C, Parmentier M, Maldonado R et al. (2004). Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC. Eur J Neurosci 20: 2203-2213.
43. Soria G, Castañé A, Ledent C, Parmentier M, Maldonado R, Valverde O (2006). The reinforcing efficacy of cocaine is diminished in mice lacking A2A adenosine receptors. Neuropsychopharmacology 31: 978-987.
44. Svenningsson P, Lindskog M, Ledent C, Parmentier M, Greengard P, Fredholm BB et al. (2000). Regulation of the phosphorylation of the dopamine- and cAMP-regulated phosphoprotein of 32 kDa in vivo by dopamine D1, dopamine D2, and adenosine A2A receptors. Proc Natl Acad Sci USA 97: 1856-1860.
45. Svenningsson P, Nairn AC, Greengard P (2005). DARPP-32 mediates the actions of multiple drugs of abuse. AAPS J 7: E353-E360.
46. Sweeney MI, White TD, Jhamandas KH, Sawynok J (1987). Morphine releases endogenous adenosine from the spinal cord in vivo. Eur J Pharmacol 141: 169-170.
47. Sweeney MI, White TD, Sawynok J (1991). Intracerebroventricular morphine releases adenosine and adenosine 3′,5′-cyclic monophosphate from the spinal cord via a serotonergic mechanism. J Pharmacol Exp Ther 259: 1013-1018.
48. Tozzi A, Tscherter A, Belcastro V, Tantucci M, Costa C, Picconi B et al. (2007). Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission. Neuropharmacology 53: 783-789.
49. Valverde O, Tzavara E, Hanoune J, Roques BP, Maldonado R (1996). Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal. Eur J Neurosci 8: 2671-2678.
50. Vortherms TA, Watts VJ (2004). Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation. J Pharmacol Exp Ther 308: 221-227.
51. Wise RA (2004). Dopamine, learning and motivation. Nat Rev Neurosci 5: 483-494.
52. Yao L, Arolfo MP, Dohrman DP, Jiang Z, Fan P, Fuchs S et al. (2002). bg dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell 109: 733-743.
53. Yao L, McFarland K, Fan P, Jiang Z, Ueda T, Diamond I (2006). Adenosine A2a blockade prevents synergy between m-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted rats. Proc Natl Acad Sci USA 103: 7877-7882.
54. Zarrindast MR, Naghipour B, Roushan-zamir F, Shafaghi B (1999). Effects of adenosine receptor agents on the expression of morphine withdrawal in mice. Eur J Pharmacol 369: 17-22.