-
1
-
-
0032694229
-
Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?
-
Drossman DA. Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome? Am J Med 1999;107:S41-50
-
(1999)
Am J Med
, vol.107
-
-
Drossman, D.A.1
-
2
-
-
0037357895
-
The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 400,000 subjects
-
Hungin AP, Whorwell PJ, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 400,000 subjects. Aliment Pharmacol Ther 2003;17:643-50
-
(2003)
Aliment Pharmacol Ther
, vol.17
, pp. 643-650
-
-
Hungin, A.P.1
Whorwell, P.J.2
Tack, J.3
Mearin, F.4
-
3
-
-
0029958797
-
The epidemiology of functional gastrointestinal disorders in North America
-
Locke GR. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol Clin North Am 1996;25:1-19
-
(1996)
Gastroenterol Clin North Am
, vol.25
, pp. 1-19
-
-
Locke, G.R.1
-
4
-
-
0025353812
-
Epidemiology of irritable bowel syndrome in the United States
-
Sandler RS. Epidemiology of irritable bowel syndrome in the United States. Gastroenterology 1990;99:409-15
-
(1990)
Gastroenterology
, vol.99
, pp. 409-415
-
-
Sandler, R.S.1
-
6
-
-
84979397863
-
Does endogenous neuronal 5-hydroxytryptamine influence canine intestinal motility?
-
49P
-
Davidson HI, Pilot MA. Does endogenous neuronal 5-hydroxytryptamine influence canine intestinal motility? J Physiol 1986;376:49P
-
(1986)
J Physiol
, vol.376
-
-
Davidson, H.I.1
Pilot, M.A.2
-
7
-
-
0000698158
-
Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex
-
Bulbring E, Crema A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol 1958;13:444-57
-
(1958)
Br J Pharmacol
, vol.13
, pp. 444-457
-
-
Bulbring, E.1
Crema, A.2
-
8
-
-
0022548844
-
Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine
-
Beubler E, Bukhave K, Rask-Madsen J. Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine. Gastroenterology 1986;90:1972-7
-
(1986)
Gastroenterology
, vol.90
, pp. 1972-1977
-
-
Beubler, E.1
Bukhave, K.2
Rask-Madsen, J.3
-
9
-
-
0018894646
-
Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport
-
Donowitz M, Asarkof N, Pike G. Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport. J Clin Invest 1980;66:341-52
-
(1980)
J Clin Invest
, vol.66
, pp. 341-352
-
-
Donowitz, M.1
Asarkof, N.2
Pike, G.3
-
10
-
-
33846347644
-
The serotonin signaling system: From basic understanding to drug development for functional GI disorders
-
Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397-414
-
(2007)
Gastroenterology
, vol.132
, pp. 397-414
-
-
Gershon, M.D.1
Tack, J.2
-
11
-
-
0037295146
-
Efficacy of alosetron in irritable bowel syndrome: A meta analysis of randomized controlled trials
-
Cremonini F, Delgado Aros S, Camilleri M. Efficacy of alosetron in irritable bowel syndrome: a meta analysis of randomized controlled trials. Neurogastroeterol Motil 2003;15:79-86
-
(2003)
Neurogastroeterol Motil
, vol.15
, pp. 79-86
-
-
Cremonini, F.1
Delgado Aros, S.2
Camilleri, M.3
-
12
-
-
0034794595
-
Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
-
Muller Lissner SA, Fumagalli I, Bardhan KD, et al. Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmaco Ther 2001;15:1655-66
-
(2001)
Aliment Pharmaco Ther
, vol.15
, pp. 1655-1666
-
-
Muller Lissner, S.A.1
Fumagalli, I.2
Bardhan, K.D.3
-
13
-
-
28144441586
-
A randomized controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
-
Tack J, Muller Lissner S, Bytzer P, et al. A randomized controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation. Gut 2005;54:1707-13
-
(2005)
Gut
, vol.54
, pp. 1707-1713
-
-
Tack, J.1
Muller Lissner, S.2
Bytzer, P.3
-
14
-
-
0029619510
-
Gastrointestinal prokinetic benzamides: The pharmacology underlying of motility
-
Brejer MR, Akkermans LMA, Schuurkes JAJ. Gastrointestinal prokinetic benzamides: the pharmacology underlying of motility. Pharmacol Rev 1995;4:631-51
-
(1995)
Pharmacol Rev
, vol.4
, pp. 631-651
-
-
Brejer, M.R.1
Akkermans, L.M.A.2
Schuurkes, J.A.J.3
-
15
-
-
0024577363
-
BRL 24924: A potent agonist at non classical 5-HT receptor positively coupled with adenylate cyclase in collicul neurons
-
Dumuis A, Sebben M, Bockaert J. BRL 24924: a potent agonist at non classical 5-HT receptor positively coupled with adenylate cyclase in collicul neurons. Eur J Pharmacol 1989;162:381-4
-
(1989)
Eur J Pharmacol
, vol.162
, pp. 381-384
-
-
Dumuis, A.1
Sebben, M.2
Bockaert, J.3
-
17
-
-
5044234596
-
Effects of single doses of renzapride on gastrointestinal motility in healthy subjects
-
Myers NL, Palmer RMJ, Wray HA, et al. Effects of single doses of renzapride on gastrointestinal motility in healthy subjects. Gut 2002;51:A137
-
(2002)
Gut
, vol.51
-
-
Myers, N.L.1
Palmer, R.M.J.2
Wray, H.A.3
-
18
-
-
5044223521
-
Effect of renzapride on transit in constipation-predominant irritable bowel syndrome
-
Camilleri M, McKinzie S, Fox J, et al. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2004;2:895-904
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, pp. 895-904
-
-
Camilleri, M.1
McKinzie, S.2
Fox, J.3
-
19
-
-
0025264408
-
Human pharmacology of renzapride: A new gastrokinetic benzamide without dopamine agonist properties
-
Staniforth DH, Pennick M. Human pharmacology of renzapride: a new gastrokinetic benzamide without dopamine agonist properties. Eur J Clin Pharmacol 1990;38:161-4
-
(1990)
Eur J Clin Pharmacol
, vol.38
, pp. 161-164
-
-
Staniforth, D.H.1
Pennick, M.2
-
21
-
-
0023767669
-
Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors
-
Butler A, Hill JM, Ireland SJ, et al. Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 1988;94:397-412
-
(1988)
Br J Pharmacol
, vol.94
, pp. 397-412
-
-
Butler, A.1
Hill, J.M.2
Ireland, S.J.3
-
25
-
-
0025922087
-
5-hydroxytryptamine 4 receptors mediate relaxation of the rat oesophagus tunica muscolaris mucosae
-
Baxter GS, Craig DA, Clarke DE. 5-hydroxytryptamine 4 receptors mediate relaxation of the rat oesophagus tunica muscolaris mucosae. Naunyn Schmeidebergs Arch Pharmacol 1991;343:439-46
-
(1991)
Naunyn Schmeidebergs Arch Pharmacol
, vol.343
, pp. 439-446
-
-
Baxter, G.S.1
Craig, D.A.2
Clarke, D.E.3
-
27
-
-
0028210437
-
4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons
-
4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994;266:G230-80
-
(1994)
Am J Physiol
, vol.266
-
-
Pan, H.1
Galligan, J.J.2
-
29
-
-
0027056770
-
Actions of 5-hydroxytriptamine on myenteric neurons in guinea pig gastric antrum
-
Tack J, Janssens J, Vantrappen G, Wood J. Actions of 5-hydroxytriptamine on myenteric neurons in guinea pig gastric antrum. Am J Physiol 1992;263:G838-46
-
(1992)
Am J Physiol
, vol.263
-
-
Tack, J.1
Janssens, J.2
Vantrappen, G.3
Wood, J.4
-
30
-
-
0027760016
-
4-receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea pig isolated ileum
-
4-receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea pig isolated ileum. Br J Pharmacol 1993;110:1572-8
-
(1993)
Br J Pharmacol
, vol.110
, pp. 1572-1578
-
-
Costall, B.1
Naylor, R.J.2
Tuladhar, B.R.3
-
31
-
-
48249119680
-
4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons
-
4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons. Am J Physiol Gastrointest Liver Physiol 2008;294:G1376-83
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.294
-
-
Ren, J.1
Zhou, Y.2
Galligan, J.J.3
-
32
-
-
0028985234
-
3 receptor antagonists in modulation of visceral hypersensitivity
-
3 receptor antagonists in modulation of visceral hypersensitivity. Br J Pharmacol 1995;114:558-62
-
(1995)
Br J Pharmacol
, vol.114
, pp. 558-562
-
-
Banner, S.J.1
Sanger, G.J.2
-
33
-
-
0026008799
-
Alfa2-adrenergic model of gastroparesis: A validation with renzapride, a stimulatory of motility
-
Gullikson GW, Virnia R, Loeffler R, Erwin WD. Alfa2-adrenergic model of gastroparesis: a validation with renzapride, a stimulatory of motility. Am J Physiol 1991;261:G426-32
-
(1991)
Am J Physiol
, vol.261
-
-
Gullikson, G.W.1
Virnia, R.2
Loeffler, R.3
Erwin, W.D.4
-
34
-
-
0030922576
-
Effect of cisapride and renzapride on gastrointestinal motility and plasma concentration in dogs
-
Song CW, Lee KY, Kim CD, et al. Effect of cisapride and renzapride on gastrointestinal motility and plasma concentration in dogs. J Pharmacol Exp Ther 1997;281:1312-6
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 1312-1316
-
-
Song, C.W.1
Lee, K.Y.2
Kim, C.D.3
-
35
-
-
25844484490
-
Basic and clinical pharmacology of new motility promoting agents
-
Galligan JJ, Vanner S. Basic and clinical pharmacology of new motility promoting agents. Neurogastr Motil 2005;17:643-53
-
(2005)
Neurogastr Motil
, vol.17
, pp. 643-653
-
-
Galligan, J.J.1
Vanner, S.2
-
36
-
-
0025736273
-
The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis
-
Mackie AD, Ferrington C, Cowan S, et al. The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis. Aliment Pharmacol Ther 1991;5:135-42
-
(1991)
Aliment Pharmacol Ther
, vol.5
, pp. 135-142
-
-
Mackie, A.D.1
Ferrington, C.2
Cowan, S.3
-
37
-
-
33646544729
-
Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation predominant bowel syndrome
-
Tack J, Middletone SJ, Horne MC, et al. Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation predominant bowel syndrome. Aliment Pharmacol Ther 2006;23:1655-65
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1655-1665
-
-
Tack, J.1
Middletone, S.J.2
Horne, M.C.3
-
38
-
-
55949095879
-
Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: An exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial
-
Spiller RC, Meyers NL, Hickling RI. Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial. Dig Dis Sci 2008
-
(2008)
Dig Dis Sci
-
-
Spiller, R.C.1
Meyers, N.L.2
Hickling, R.I.3
-
39
-
-
41849096775
-
Clinical trial: Renzapride therapy for constipation-predominant irritable bowel syndrome: multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting
-
George AM, Meyers NL, Hickling RI. Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome: multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting. Aliment Pharmacol Ther 2008;27:830-7
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 830-837
-
-
George, A.M.1
Meyers, N.L.2
Hickling, R.I.3
-
40
-
-
0038724271
-
Sex-related differences in IBS patients: Central processing of visceral stimuli
-
Naliboff BD, Berman S, Chang L, et al. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003;124:1738-47
-
(2003)
Gastroenterology
, vol.124
, pp. 1738-1747
-
-
Naliboff, B.D.1
Berman, S.2
Chang, L.3
-
41
-
-
0036122008
-
Sex and age differences in the pharmacokinetics of alosetron
-
Koch KM, Palmer JL, Noordin N, et al. Sex and age differences in the pharmacokinetics of alosetron. Br J Clin Pharmacol 2002;53:238-42
-
(2002)
Br J Clin Pharmacol
, vol.53
, pp. 238-242
-
-
Koch, K.M.1
Palmer, J.L.2
Noordin, N.3
-
42
-
-
16444362290
-
3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
-
3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome. Neurogastroenterol Motil 2005;17:212-21
-
(2005)
Neurogastroenterol Motil
, vol.17
, pp. 212-221
-
-
Nakai, A.1
Diksic, M.2
Kumakura, Y.3
-
43
-
-
54949122854
-
-
Alyzime press release. April 2008. Available from: http://www.alizyme.com/alizyme/media/press/show.jsp?ref=128 [Last accessed 2008 September 3]
-
Alyzime press release. April 2008. Available from: http://www.alizyme.com/alizyme/media/press/show.jsp?ref=128 [Last accessed 2008 September 3]
-
-
-
-
44
-
-
36949024233
-
The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome
-
Meyers NL, Hickling RI. The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome. J Int Med Res 2007;35:848-66
-
(2007)
J Int Med Res
, vol.35
, pp. 848-866
-
-
Meyers, N.L.1
Hickling, R.I.2
-
45
-
-
0035197735
-
Gastrointestinal prokinetic drugs have different affinity for the human cardiac ether-à-go go channel
-
Potet F, Bouyssou T, Escande D, Baro' I. Gastrointestinal prokinetic drugs have different affinity for the human cardiac ether-à-go go channel. J Pharm Exp Ther 2001;299:1007-12
-
(2001)
J Pharm Exp Ther
, vol.299
, pp. 1007-1012
-
-
Potet, F.1
Bouyssou, T.2
Escande, D.3
Baro', I.4
-
47
-
-
37549071002
-
Pharmacology and metabolism of renzapride: A novel therapeutic agent for the potential treatment of irritable bowel syndrome
-
Meyers NL, Hickling R. Pharmacology and metabolism of renzapride: a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs R&D 2008;9:37-63
-
(2008)
Drugs R&D
, vol.9
, pp. 37-63
-
-
Meyers, N.L.1
Hickling, R.2
-
49
-
-
0027469647
-
3-receptor antagonist in patients with irritable bowel syndrome
-
3-receptor antagonist in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1993; 7:175-80
-
(1993)
Aliment Pharmacol Ther
, vol.7
, pp. 175-180
-
-
Prior, A.1
Read, N.W.2
-
50
-
-
0034066325
-
3 receptor antagonist alosetron inhibits the colorectal distension-induced depressor response and spinal c-fos expression in the anaesthetized rat
-
3 receptor antagonist alosetron inhibits the colorectal distension-induced depressor response and spinal c-fos expression in the anaesthetized rat. Gut 2000;46:474-80
-
(2000)
Gut
, vol.46
, pp. 474-480
-
-
Kozlowski, C.M.1
Green, A.2
Grundy, D.3
-
51
-
-
0034917335
-
A randomized controlled clinical trial of the serotonin type-3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome
-
Camilleri M, Chey WY, Mayer EA, et al. A randomized controlled clinical trial of the serotonin type-3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001
-
(2001)
Arch Intern Med
-
-
Camilleri, M.1
Chey, W.Y.2
Mayer, E.A.3
-
53
-
-
0031658491
-
Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
-
Delvaux M, Louvel D, Mamet JP, et al. Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1998;12:849-55
-
(1998)
Aliment Pharmacol Ther
, vol.12
, pp. 849-855
-
-
Delvaux, M.1
Louvel, D.2
Mamet, J.P.3
-
54
-
-
20044379425
-
The placebo effect in irritable bowel syndrome trials: A meta-analysis
-
Patel SM, Stason WB, Legedza A, et al. The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol Motil 2005;17:332-40
-
(2005)
Neurogastroenterol Motil
, vol.17
, pp. 332-340
-
-
Patel, S.M.1
Stason, W.B.2
Legedza, A.3
|