메뉴 건너뛰기




Volumn 17, Issue 11, 2008, Pages 1663-1670

Renzapride: A new drug for the treatment of constipation in the irritable bowel syndrome

Author keywords

5 hydroxytryptamine; Constipation; Irritable bowel syndrome; Renzapride

Indexed keywords

4 AMINO 5 CHLORO 2 METHOXYBENZOIC ACID 2 (DIETHYLAMINO)ETHYL ESTER; 4 AMINO 5 CHLORO N (OCTAHYDRO 6 METHYL 2H QUINOLIZIN 2 YL) ORTHO ANISAMIDE; 5 METHOXYTRYPTAMINE; BEMESETRON; CISAPRIDE; GASTRIN; GRANISETRON; METHYSERGIDE; METOCLOPRAMIDE; MOTILIN; ONDANSETRON; PLACEBO; RENZAPRIDE; SEROTONIN 3 ANTAGONIST; SEROTONIN 4 AGONIST; SEROTONIN 4 RECEPTOR; TROPISETRON; ZACOPRIDE; ZATOSETRON;

EID: 54949095492     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.17.11.1663     Document Type: Review
Times cited : (16)

References (54)
  • 1
    • 0032694229 scopus 로고    scopus 로고
    • Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?
    • Drossman DA. Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome? Am J Med 1999;107:S41-50
    • (1999) Am J Med , vol.107
    • Drossman, D.A.1
  • 2
    • 0037357895 scopus 로고    scopus 로고
    • The prevalence, patterns and impact of irritable bowel syndrome: An international survey of 400,000 subjects
    • Hungin AP, Whorwell PJ, Tack J, Mearin F. The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 400,000 subjects. Aliment Pharmacol Ther 2003;17:643-50
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 643-650
    • Hungin, A.P.1    Whorwell, P.J.2    Tack, J.3    Mearin, F.4
  • 3
    • 0029958797 scopus 로고    scopus 로고
    • The epidemiology of functional gastrointestinal disorders in North America
    • Locke GR. The epidemiology of functional gastrointestinal disorders in North America. Gastroenterol Clin North Am 1996;25:1-19
    • (1996) Gastroenterol Clin North Am , vol.25 , pp. 1-19
    • Locke, G.R.1
  • 4
    • 0025353812 scopus 로고
    • Epidemiology of irritable bowel syndrome in the United States
    • Sandler RS. Epidemiology of irritable bowel syndrome in the United States. Gastroenterology 1990;99:409-15
    • (1990) Gastroenterology , vol.99 , pp. 409-415
    • Sandler, R.S.1
  • 6
    • 84979397863 scopus 로고
    • Does endogenous neuronal 5-hydroxytryptamine influence canine intestinal motility?
    • 49P
    • Davidson HI, Pilot MA. Does endogenous neuronal 5-hydroxytryptamine influence canine intestinal motility? J Physiol 1986;376:49P
    • (1986) J Physiol , vol.376
    • Davidson, H.I.1    Pilot, M.A.2
  • 7
    • 0000698158 scopus 로고
    • Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex
    • Bulbring E, Crema A. Observations concerning the action of 5-hydroxytryptamine on the peristaltic reflex. Br J Pharmacol 1958;13:444-57
    • (1958) Br J Pharmacol , vol.13 , pp. 444-457
    • Bulbring, E.1    Crema, A.2
  • 8
    • 0022548844 scopus 로고
    • Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine
    • Beubler E, Bukhave K, Rask-Madsen J. Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine. Gastroenterology 1986;90:1972-7
    • (1986) Gastroenterology , vol.90 , pp. 1972-1977
    • Beubler, E.1    Bukhave, K.2    Rask-Madsen, J.3
  • 9
    • 0018894646 scopus 로고
    • Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport
    • Donowitz M, Asarkof N, Pike G. Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport. J Clin Invest 1980;66:341-52
    • (1980) J Clin Invest , vol.66 , pp. 341-352
    • Donowitz, M.1    Asarkof, N.2    Pike, G.3
  • 10
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007;132:397-414
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 11
    • 0037295146 scopus 로고    scopus 로고
    • Efficacy of alosetron in irritable bowel syndrome: A meta analysis of randomized controlled trials
    • Cremonini F, Delgado Aros S, Camilleri M. Efficacy of alosetron in irritable bowel syndrome: a meta analysis of randomized controlled trials. Neurogastroeterol Motil 2003;15:79-86
    • (2003) Neurogastroeterol Motil , vol.15 , pp. 79-86
    • Cremonini, F.1    Delgado Aros, S.2    Camilleri, M.3
  • 12
    • 0034794595 scopus 로고    scopus 로고
    • Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation
    • Muller Lissner SA, Fumagalli I, Bardhan KD, et al. Tegaserod, a 5HT4 receptor partial agonist, relieves symptoms in irritable bowel syndrome patients with abdominal pain, bloating and constipation. Aliment Pharmaco Ther 2001;15:1655-66
    • (2001) Aliment Pharmaco Ther , vol.15 , pp. 1655-1666
    • Muller Lissner, S.A.1    Fumagalli, I.2    Bardhan, K.D.3
  • 13
    • 28144441586 scopus 로고    scopus 로고
    • A randomized controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation
    • Tack J, Muller Lissner S, Bytzer P, et al. A randomized controlled trial assessing the efficacy and safety of repeated tegaserod therapy in women with irritable bowel syndrome with constipation. Gut 2005;54:1707-13
    • (2005) Gut , vol.54 , pp. 1707-1713
    • Tack, J.1    Muller Lissner, S.2    Bytzer, P.3
  • 14
    • 0029619510 scopus 로고
    • Gastrointestinal prokinetic benzamides: The pharmacology underlying of motility
    • Brejer MR, Akkermans LMA, Schuurkes JAJ. Gastrointestinal prokinetic benzamides: the pharmacology underlying of motility. Pharmacol Rev 1995;4:631-51
    • (1995) Pharmacol Rev , vol.4 , pp. 631-651
    • Brejer, M.R.1    Akkermans, L.M.A.2    Schuurkes, J.A.J.3
  • 15
    • 0024577363 scopus 로고
    • BRL 24924: A potent agonist at non classical 5-HT receptor positively coupled with adenylate cyclase in collicul neurons
    • Dumuis A, Sebben M, Bockaert J. BRL 24924: a potent agonist at non classical 5-HT receptor positively coupled with adenylate cyclase in collicul neurons. Eur J Pharmacol 1989;162:381-4
    • (1989) Eur J Pharmacol , vol.162 , pp. 381-384
    • Dumuis, A.1    Sebben, M.2    Bockaert, J.3
  • 17
    • 5044234596 scopus 로고    scopus 로고
    • Effects of single doses of renzapride on gastrointestinal motility in healthy subjects
    • Myers NL, Palmer RMJ, Wray HA, et al. Effects of single doses of renzapride on gastrointestinal motility in healthy subjects. Gut 2002;51:A137
    • (2002) Gut , vol.51
    • Myers, N.L.1    Palmer, R.M.J.2    Wray, H.A.3
  • 18
    • 5044223521 scopus 로고    scopus 로고
    • Effect of renzapride on transit in constipation-predominant irritable bowel syndrome
    • Camilleri M, McKinzie S, Fox J, et al. Effect of renzapride on transit in constipation-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2004;2:895-904
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 895-904
    • Camilleri, M.1    McKinzie, S.2    Fox, J.3
  • 19
    • 0025264408 scopus 로고
    • Human pharmacology of renzapride: A new gastrokinetic benzamide without dopamine agonist properties
    • Staniforth DH, Pennick M. Human pharmacology of renzapride: a new gastrokinetic benzamide without dopamine agonist properties. Eur J Clin Pharmacol 1990;38:161-4
    • (1990) Eur J Clin Pharmacol , vol.38 , pp. 161-164
    • Staniforth, D.H.1    Pennick, M.2
  • 21
    • 0023767669 scopus 로고
    • Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors
    • Butler A, Hill JM, Ireland SJ, et al. Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 1988;94:397-412
    • (1988) Br J Pharmacol , vol.94 , pp. 397-412
    • Butler, A.1    Hill, J.M.2    Ireland, S.J.3
  • 25
    • 0025922087 scopus 로고
    • 5-hydroxytryptamine 4 receptors mediate relaxation of the rat oesophagus tunica muscolaris mucosae
    • Baxter GS, Craig DA, Clarke DE. 5-hydroxytryptamine 4 receptors mediate relaxation of the rat oesophagus tunica muscolaris mucosae. Naunyn Schmeidebergs Arch Pharmacol 1991;343:439-46
    • (1991) Naunyn Schmeidebergs Arch Pharmacol , vol.343 , pp. 439-446
    • Baxter, G.S.1    Craig, D.A.2    Clarke, D.E.3
  • 27
    • 0028210437 scopus 로고
    • 4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons
    • 4 receptors mediate inhibition and facilitation of fast synaptic transmission in enteric neurons. Am J Physiol 1994;266:G230-80
    • (1994) Am J Physiol , vol.266
    • Pan, H.1    Galligan, J.J.2
  • 29
    • 0027056770 scopus 로고
    • Actions of 5-hydroxytriptamine on myenteric neurons in guinea pig gastric antrum
    • Tack J, Janssens J, Vantrappen G, Wood J. Actions of 5-hydroxytriptamine on myenteric neurons in guinea pig gastric antrum. Am J Physiol 1992;263:G838-46
    • (1992) Am J Physiol , vol.263
    • Tack, J.1    Janssens, J.2    Vantrappen, G.3    Wood, J.4
  • 30
    • 0027760016 scopus 로고
    • 4-receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea pig isolated ileum
    • 4-receptor mediated facilitation of the emptying phase of the peristaltic reflex in the guinea pig isolated ileum. Br J Pharmacol 1993;110:1572-8
    • (1993) Br J Pharmacol , vol.110 , pp. 1572-1578
    • Costall, B.1    Naylor, R.J.2    Tuladhar, B.R.3
  • 31
    • 48249119680 scopus 로고    scopus 로고
    • 4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons
    • 4 receptor activation facilitates recovery from synaptic rundown and increases transmitter release from single varicosities of myenteric neurons. Am J Physiol Gastrointest Liver Physiol 2008;294:G1376-83
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Ren, J.1    Zhou, Y.2    Galligan, J.J.3
  • 32
    • 0028985234 scopus 로고
    • 3 receptor antagonists in modulation of visceral hypersensitivity
    • 3 receptor antagonists in modulation of visceral hypersensitivity. Br J Pharmacol 1995;114:558-62
    • (1995) Br J Pharmacol , vol.114 , pp. 558-562
    • Banner, S.J.1    Sanger, G.J.2
  • 33
    • 0026008799 scopus 로고
    • Alfa2-adrenergic model of gastroparesis: A validation with renzapride, a stimulatory of motility
    • Gullikson GW, Virnia R, Loeffler R, Erwin WD. Alfa2-adrenergic model of gastroparesis: a validation with renzapride, a stimulatory of motility. Am J Physiol 1991;261:G426-32
    • (1991) Am J Physiol , vol.261
    • Gullikson, G.W.1    Virnia, R.2    Loeffler, R.3    Erwin, W.D.4
  • 34
    • 0030922576 scopus 로고    scopus 로고
    • Effect of cisapride and renzapride on gastrointestinal motility and plasma concentration in dogs
    • Song CW, Lee KY, Kim CD, et al. Effect of cisapride and renzapride on gastrointestinal motility and plasma concentration in dogs. J Pharmacol Exp Ther 1997;281:1312-6
    • (1997) J Pharmacol Exp Ther , vol.281 , pp. 1312-1316
    • Song, C.W.1    Lee, K.Y.2    Kim, C.D.3
  • 35
    • 25844484490 scopus 로고    scopus 로고
    • Basic and clinical pharmacology of new motility promoting agents
    • Galligan JJ, Vanner S. Basic and clinical pharmacology of new motility promoting agents. Neurogastr Motil 2005;17:643-53
    • (2005) Neurogastr Motil , vol.17 , pp. 643-653
    • Galligan, J.J.1    Vanner, S.2
  • 36
    • 0025736273 scopus 로고
    • The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis
    • Mackie AD, Ferrington C, Cowan S, et al. The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis. Aliment Pharmacol Ther 1991;5:135-42
    • (1991) Aliment Pharmacol Ther , vol.5 , pp. 135-142
    • Mackie, A.D.1    Ferrington, C.2    Cowan, S.3
  • 37
    • 33646544729 scopus 로고    scopus 로고
    • Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation predominant bowel syndrome
    • Tack J, Middletone SJ, Horne MC, et al. Pilot study of the efficacy of renzapride on gastrointestinal motility and symptoms in patients with constipation predominant bowel syndrome. Aliment Pharmacol Ther 2006;23:1655-65
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1655-1665
    • Tack, J.1    Middletone, S.J.2    Horne, M.C.3
  • 38
    • 55949095879 scopus 로고    scopus 로고
    • Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: An exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial
    • Spiller RC, Meyers NL, Hickling RI. Identification of patients with non-D, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial. Dig Dis Sci 2008
    • (2008) Dig Dis Sci
    • Spiller, R.C.1    Meyers, N.L.2    Hickling, R.I.3
  • 39
    • 41849096775 scopus 로고    scopus 로고
    • Clinical trial: Renzapride therapy for constipation-predominant irritable bowel syndrome: multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting
    • George AM, Meyers NL, Hickling RI. Clinical trial: renzapride therapy for constipation-predominant irritable bowel syndrome: multicentre, randomized, placebo-controlled, double-blind study in primary healthcare setting. Aliment Pharmacol Ther 2008;27:830-7
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 830-837
    • George, A.M.1    Meyers, N.L.2    Hickling, R.I.3
  • 40
    • 0038724271 scopus 로고    scopus 로고
    • Sex-related differences in IBS patients: Central processing of visceral stimuli
    • Naliboff BD, Berman S, Chang L, et al. Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 2003;124:1738-47
    • (2003) Gastroenterology , vol.124 , pp. 1738-1747
    • Naliboff, B.D.1    Berman, S.2    Chang, L.3
  • 41
    • 0036122008 scopus 로고    scopus 로고
    • Sex and age differences in the pharmacokinetics of alosetron
    • Koch KM, Palmer JL, Noordin N, et al. Sex and age differences in the pharmacokinetics of alosetron. Br J Clin Pharmacol 2002;53:238-42
    • (2002) Br J Clin Pharmacol , vol.53 , pp. 238-242
    • Koch, K.M.1    Palmer, J.L.2    Noordin, N.3
  • 42
    • 16444362290 scopus 로고    scopus 로고
    • 3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome
    • 3 antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel syndrome. Neurogastroenterol Motil 2005;17:212-21
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 212-221
    • Nakai, A.1    Diksic, M.2    Kumakura, Y.3
  • 43
    • 54949122854 scopus 로고    scopus 로고
    • Alyzime press release. April 2008. Available from: http://www.alizyme.com/alizyme/media/press/show.jsp?ref=128 [Last accessed 2008 September 3]
    • Alyzime press release. April 2008. Available from: http://www.alizyme.com/alizyme/media/press/show.jsp?ref=128 [Last accessed 2008 September 3]
  • 44
    • 36949024233 scopus 로고    scopus 로고
    • The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome
    • Meyers NL, Hickling RI. The cardiovascular safety profile of renzapride, a novel treatment for irritable bowel syndrome. J Int Med Res 2007;35:848-66
    • (2007) J Int Med Res , vol.35 , pp. 848-866
    • Meyers, N.L.1    Hickling, R.I.2
  • 45
    • 0035197735 scopus 로고    scopus 로고
    • Gastrointestinal prokinetic drugs have different affinity for the human cardiac ether-à-go go channel
    • Potet F, Bouyssou T, Escande D, Baro' I. Gastrointestinal prokinetic drugs have different affinity for the human cardiac ether-à-go go channel. J Pharm Exp Ther 2001;299:1007-12
    • (2001) J Pharm Exp Ther , vol.299 , pp. 1007-1012
    • Potet, F.1    Bouyssou, T.2    Escande, D.3    Baro', I.4
  • 47
    • 37549071002 scopus 로고    scopus 로고
    • Pharmacology and metabolism of renzapride: A novel therapeutic agent for the potential treatment of irritable bowel syndrome
    • Meyers NL, Hickling R. Pharmacology and metabolism of renzapride: a novel therapeutic agent for the potential treatment of irritable bowel syndrome. Drugs R&D 2008;9:37-63
    • (2008) Drugs R&D , vol.9 , pp. 37-63
    • Meyers, N.L.1    Hickling, R.2
  • 49
    • 0027469647 scopus 로고
    • 3-receptor antagonist in patients with irritable bowel syndrome
    • 3-receptor antagonist in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1993; 7:175-80
    • (1993) Aliment Pharmacol Ther , vol.7 , pp. 175-180
    • Prior, A.1    Read, N.W.2
  • 50
    • 0034066325 scopus 로고    scopus 로고
    • 3 receptor antagonist alosetron inhibits the colorectal distension-induced depressor response and spinal c-fos expression in the anaesthetized rat
    • 3 receptor antagonist alosetron inhibits the colorectal distension-induced depressor response and spinal c-fos expression in the anaesthetized rat. Gut 2000;46:474-80
    • (2000) Gut , vol.46 , pp. 474-480
    • Kozlowski, C.M.1    Green, A.2    Grundy, D.3
  • 51
    • 0034917335 scopus 로고    scopus 로고
    • A randomized controlled clinical trial of the serotonin type-3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome
    • Camilleri M, Chey WY, Mayer EA, et al. A randomized controlled clinical trial of the serotonin type-3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001
    • (2001) Arch Intern Med
    • Camilleri, M.1    Chey, W.Y.2    Mayer, E.A.3
  • 52
  • 53
    • 0031658491 scopus 로고    scopus 로고
    • Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
    • Delvaux M, Louvel D, Mamet JP, et al. Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 1998;12:849-55
    • (1998) Aliment Pharmacol Ther , vol.12 , pp. 849-855
    • Delvaux, M.1    Louvel, D.2    Mamet, J.P.3
  • 54
    • 20044379425 scopus 로고    scopus 로고
    • The placebo effect in irritable bowel syndrome trials: A meta-analysis
    • Patel SM, Stason WB, Legedza A, et al. The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol Motil 2005;17:332-40
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 332-340
    • Patel, S.M.1    Stason, W.B.2    Legedza, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.