Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection

Journal of Chromatography A

Volumn 1211, Issue 1-2, 2008, Pages 22-32

  Vera Candioti, L ^a   Gil Garcia M D ^b   Martinez Galera M ^b   Goicoechea, H C ^a  

^a UNIVERSIDAD NACIONAL DEL LITORAL   (Argentina)

^b UNIVERSITY OF ALMERÍA   (Spain)

Author keywords

Experimental design; Liquid chromatography diode array detection; Pharmaceuticals; River water; Solid phase microextraction

Indexed keywords

ACETIC ACID; AMIDES; BODY FLUIDS; CALIBRATION; CARBOXYLIC ACIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CONCENTRATION (PROCESS); CURVE FITTING; DESORPTION; DIODES; DRUG PRODUCTS; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIC STRENGTH; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; PH EFFECTS; RIVERS; SILICONES; SOLVENT EXTRACTION; SOLVENTS; UNCERTAINTY ANALYSIS;

ANALYTE; ANALYTES; ANALYTICAL METHODS; ANTIEPILEPTIC DRUGS; CALIBRATION GRAPHS; CARBAMAZEPINE; CENTRAL COMPOSITE DESIGNS; CHEMOMETRIC; CONCENTRATION LEVELS; DESIRABILITY FUNCTIONS; DICLOFENAC; DIODE ARRAY DETECTIONS; EXPERIMENTAL CONDITIONS; EXPERIMENTAL DESIGN; EXTRACTION TIMES; INDOMETHACIN; INFLAMMATORY DRUGS; KETOPROFEN; LIMITS OF QUANTITATIONS; MATRIX EFFECTS; METHOD DETECTION LIMITS; MULTIPLE RESPONSES; NAPROXEN; ON-LINE; OPERATIONAL CONDITIONS; PHARMACEUTICAL COMPOUNDS; PHARMACEUTICALS; PIROXICAM; POSITIVE EFFECTS; PRECONCENTRATION; RANGING; RIVER WATER; RIVER WATER SAMPLES; RIVER WATERS; SAMPLE PHS; SCREENING DESIGNS; SIMULTANEOUS DETERMINATIONS; SIMULTANEOUS OPTIMIZATIONS; SOAKING PERIODS; SOLID-PHASE MICROEXTRACTION; STIRRING RATES; STIRRING TIMES;

EXTRACTION;

CARBAMAZEPINE; DICLOFENAC; DIFLUNISAL; DIMETICONE; DIVINYLBENZENE; INDOMETACIN; KETOPROFEN; NAPROXEN; ORGANIC SOLVENT; PIROXICAM; RIVER WATER; SULINDAC;

ACCURACY; ARTICLE; CHEMOMETRIC ANALYSIS; CONCENTRATION (PARAMETERS); DESORPTION; IONIC STRENGTH; LIQUID CHROMATOGRAPHY; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SOLID PHASE MICROEXTRACTION; TEMPERATURE MEASUREMENT; WATER SAMPLING;

ADSORPTION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICONVULSANTS; CHROMATOGRAPHY, LIQUID; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; RIVERS; SENSITIVITY AND SPECIFICITY; SOLID PHASE MICROEXTRACTION; WATER POLLUTANTS, CHEMICAL;

EID: 54949092756     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.09.093     Document Type: Article

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