A lecithinized superoxide dismutase (PC-SOD) improves ulcerative colitis

Colorectal Disease

Volumn 10, Issue 9, 2008, Pages 931-934

  Suzuki, Y ^a   Matsumoto, T ^b   Okamoto, S ^c   Hibi, T ^c  

^a TOHO UNIVERSITY SAKURA MEDICAL CENTER   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

PC SOD; Superoxide dismutase; Ulcerative colitis

Indexed keywords

AZATHIOPRINE; MERCAPTOPURINE; MESALAZINE; PHOSPHATIDYLCHOLINE; SALAZOSULFAPYRIDINE; STEROID; SUPEROXIDE DISMUTASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED HEADACHE; DRUG SAFETY; FEMALE; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; LEUKOCYTE COUNT; LOW BACK PAIN; MALAISE; MALE; NAUSEA; PILOT STUDY; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; ULCERATIVE COLITIS;

COLITIS, ULCERATIVE; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; MALE; PHOSPHATIDYLCHOLINES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 54949090399     PISSN: 14628910     EISSN: 14631318     Source Type: Journal    
DOI: 10.1111/j.1463-1318.2008.01487.x     Document Type: Article

References (15)

1. Rezaie A, Parker RD, Rezaie A. Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause? Dig Dis Sci 2007; 52: 2015-21.
2. McCord JM, Edeas MA. SOD, oxidative stress and human pathologies: A brief history and a future vision. Biomed Pharmacother 2005; 59: 139-42.
3. Hernandez-Saavedra D, Zhou H, McCord JM. Anti-inflammatory properties of a chimeric recombinant superoxide dismutase: SOD2/3. Biomed Pharmacother 2005; 59: 204-8.
4. Flaherty JT, Pitt B, Gruber JW et al. Recombinant human superoxide dismutase (h-SOD) fails to improve recovery of ventricular function in patients undergoing coronary angioplasty for acute myocardial infarction. Circulation 1994; 89: 1982-91.
5. Igarashi R, Hoshino J, Ochiai A et al. Lecithinized superoxide dismutase enhances its pharmacologic potency by increasing its cell membrane affinity. J Pharmacol Exp Ther 1994; 271: 1672-7.
6. Igarashi R, Hoshino J, Takenaga M et al. Lecithinization of superoxide dismutase potentiates its protective effect against Forssman antiserum-induced elevation in guinea pig airway resistance. J Pharmacol Exp Ther 1992; 262: 1214-9.
7. Hori Y, Hoshino J, Yamazaki C et al. Effect of lecithinized-superoxide dismutase on the rat colitis model induced by dextran sulfate sodium. Jpn J Pharmacol 1997; 7: 99-103.
8. Yunoki M, Kawauchi M, Ukita N et al. Effects of lecithinized superoxide dismutase on traumatic brain injury in rats. J Neurotrauma 1997; 14: 739-46.
9. Takenaga M, Ohta Y, Tokura Y et al. Lecithinized superoxide dismutase (PC-SOD) improved spinal cord injury-induced motor dysfunction through suppression of oxidative stress and enhancement of neurotrophic factor production. J Control Release 2006; 110: 283-9.
10. Tsubokawa T, Jadhav V, Solaroglu I et al. Lecithinized superoxide dismutase improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Stroke 2007; 38: 1057-62.
11. Chikawa T, Ikata T, Katoh S et al. Preventive effects of lecithinized superoxide dismutase and methylpredonisolone on spinal cord injury in rats: Transcriptional regulation of inflammatory and neurotrophic genes. J Neurotrauma 2001; 18: 93-103.
12. Hangaishi M, Nakajima H, Taguchi J et al. Lecithinized Cu, Zn-superoxide dismutase limits the infarct size following ischemia-reperfusion injury in rat hearts in vivo. Biochem Biophys Res Commun 2001; 285: 1220-5.
13. Kornbluth A, Sashar DB; Practice Parameters Committee of the American College of Gastroenterology. Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 2004; 99: 1371-85.
14. Sninsky CA, Cort DH, Shanahan F et al. Oral mesalamine (asacol) for mildly to moderately active ulcerative colitis. Ann Intern Med 1991; 115: 350-5.
15. Broeyer FJ, van Aken BE, Suzuki J et al. The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man. Br J Clin Pharmacol 2007 [in press].