Pilot study using doxycycline-releasing stents to ameliorate postoperative healing quality after sinus surgery

Wound Repair and Regeneration

Volumn 16, Issue 6, 2008, Pages 757-767

  Huvenne, Wouter ^a   Zhang, Nan ^a   Tijsma, Edze ^b   Hissong, Britt ^c   Huurdeman, Judtih ^b   Holtappels, Gabriele ^a   Claeys, Sofie ^a   Van Cauwenberge, Paul ^a   Nelis, Hans ^d   Coenye, Tom ^d   Bachert, Claus ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b MEDTRONIC BAKKEN RESEARCH CENTER   (Netherlands)

^c Medtronic ENT   (United States)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE B; PLACEBO;

ADULT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; CELL VIABILITY; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ELUTING STENT; ENDOSCOPIC SURGERY; ENZYME ANALYSIS; ENZYME INHIBITION; FEMALE; FRONTAL SINUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; NOSE POLYP; PARANASAL SINUS; PILOT STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RHINOSINUSITIS; SURGICAL INFECTION; SURGICAL WOUND; SYMPTOMATOLOGY; VISUAL ANALOG SCALE; WOUND CLOSURE; WOUND HEALING;

ADULT; DOXYCYCLINE; DRUG-ELUTING STENTS; FEMALE; HUMANS; MALE; PARANASAL SINUS DISEASES; PILOT PROJECTS; PROSPECTIVE STUDIES; WOUND HEALING;

EID: 54949087837     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2008.00429.x     Document Type: Article

References (45)

1. Fokkens W, Lund V, Mullol J. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology 2007 45 : 97 101.
2. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, Bachert C, Baraniuk J, Baroody FM, Benninger MS, Brook I, Chowdhury BA, Druce HM, Durham S, Ferguson B, Gwaltney JM, Kaliner M, Kennedy DW, Lund V, Naclerio R, Pawankar R, Piccirillo JF, Rohane P, Simon R, Slavin RG, Togias A, Wald ER, Zinreich SJ. American Academy of Allergy, Asthma and Immunology (AAAAI); American Academy of Otolaryngic Allergy (AAOA); American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS); American College of Allergy, Asthma and Immunology (ACAAI); American Rhinologic Society (ARS). Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol 2004 114 (6 Suppl.) : 155 212.
3. Collins JG. Prevalence of selected chronic conditions: United States, 1990-1992. Vital Health Stat 10 1997 194 : 1 89.
4. Van Zele T, Claeys S, Gevaert P, Van Maele G, Holtappels G, Van Cauwenberge P, Bachert C. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy 2006 61 : 1280 9.
5. Watelet JB, Bachert C, Claeys C, Van Cauwenberge P. Matrix metalloproteinases MMP-7, MMP-9 and their tissue inhibitor TIMP-1: expression in chronic sinusitis vs nasal polyposis. Allergy 2004 59 : 54 60.
6. Moses RL, Cornetta A, Atkins JP, Roth M, Rosen MR, Keane WM. Revision of endoscopic sinus surgery: the Thomas Jefferson. Ear Nose Throat J 1998 77 : 190.
7. Corey JP, Bumsted RM. Revision endoscopic ethmoidectomy for chronic rhinosinusitis. Otolaryngol Clin North Am 1989 22 : 801 8.
8. Senior BA, Kennedy DW, Tanabodee J, Kroger H, Hassab M, Lanza D. Long-term results of functional endoscopic sinus surgery. Laryngoscope 1998 108 : 151 7.
9. McFadden EA, Woodson BT, Massaro BM, Toohill RJ. Orbital complications of sinusitis in the aspirin triad syndrome. Laryngoscope 1996 106 (Part 1) : 1103 7.
10. Kennedy DW. Prognostic factors, outcomes and staging in ethmoid sinus surgery. Laryngoscope 1992 102 (part 2 Suppl. 57) : 1 18.
11. Watelet JB, Claeys C, Van Cauwenberge P, Bachert C. Predictive and monitoring value of matrix metalloproteinase-9 for healing quality after sinus surgery. Wound Rep Regen 2004 12 : 412 8.
12. Beekman B, Verzijl N, de Roos JA, Koopman JL, TeKoppele JM. Doxyclycline inhibits collagen synthesis by bovine chondrocytes cultured in alginate. Biochem Biophys Res Commun 1997 237 : 107 10.
13. Gilbertson-Beadling S, Powers EA, Stamp-Cole M, Scott PS, Wallace TL, Copeland J, Petzhold G, Mitchell M, Ledbetter S, Poorman R. The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism. Cancer Chemother Pharmacol 1995 36 : 418 24.
14. Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 1998 12 : 12 26.
15. Golub LM, Sorsa T, Lee HM, Ciancio S, Sorbi D, Ramamurthy NS, Gruber B, Salo T, Konttinen YT. Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva. J Clin Periodontol 1995 22 : 100 9.
16. Wu LM, Fan L, Chen LL. Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007 19 : 679 82.
17. Shlopov BV, Smith GN Jr., Cole AA, Hasty KA. Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes. Arthr Rheum 1999 42 : 719 27.
18. Kol R, Palattella A. The use of doxycycline in periodontology. Histologic in vivo study on mice affected by diabetes mellitus. Minerva Stomatol 2006 55 : 77 86.
19. Lamparter S, Slight SH, Weber KT. Doxycycline and tissue repair in rats. J Lab Clin Med 2002 139 : 295 302.
20. Gapski R, Barr JL, Sarment DP, Layher MG, Socransky SS, Giannobile WV. Effect of systemic matrix metalloproteinase inhibition on periodontal wound repair: a proof of concept trial. J Periodontol 2004 75 : 441 52.
21. Rains BM. III. Frontal sinus stenting. Otolaryngol Clin North Am 2001 34 : 101 10.
22. Hosemann W, Schindler E, Wiegrebe E, Gopferich A. Innovative frontal sinus stent acting as a local drug-releasing system. Eur Arch Otorhinolaryngol 2003 260 : 131 4.
23. Bachert C. A punch for enlarging the frontal ostium. Laryngorhinootologie 1999 78 : 579 80.
24. Lefmann M, Schweickert B, Buchholz P, Göbel UB, Ulrichs T, Seiler P, Theegarten D, Moter A. Evaluation of peptide nucleic acid-fluorescence in situ hybridization for identification of clinically relevant mycobacteria in clinical specimens and tissue sections. J Clin Microbiol 2006 44 : 3760 7.
25. Messerklinger W. Endoscopy of the nose. Monatsschr Ohrenheilkd Laryngorhinol 1970 104 : 451 6.
26. King JM, Caldarelli DD, Pigato JB. A review of revision functional endoscopic sinus surgery. Laryngoscope 1994 104 : 404 8.
27. Bove PF, Wesley UV, Greul AK, Hristova M, Dostmann WR, van der Vliet A. Nitric oxide promotes airway epithelial wound repair through enhanced activation of MMP-9. Am J Respir Cell Mol Biol 2007 36 : 138 46.
28. Parks WC, Shapiro SD. Matrix metalloproteinases in lung biology. Respir Res 2001 2 : 10 19.
29. Van den Steen PE, Dubois B, Nelissen I, Rudd PM, Dwek RA, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002 375 536.
30. Opdenakker G, Van den Steen PE, Dubois B, Nelissen I, Van Coillie E, Masure S, Proost P, Van Damme J. Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol 2001 69 : 851 9.
31. Atkinson JJ, Senior RM. Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol 2003 12 24.
32. Legrand C, Gilles C, Zahm JM, Polette M, Buisson AC, Kaplan H, Birembaut P, Tournier JM. Airway epithelial cell migration dynamics. MMP-9 role in cell-extracellular matrix remodeling. J Cell Biol 1999 146 : 517 29.
33. Van den Steen EP, Dubois B, Nelissen I, Rudd P, Dwek R, Opdenakker G. Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9). Crit Rev Biochem Mol Biol 2002 37 : 375 536.
34. Dahlen B, Shute J, Howarth P. Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma. Thorax 1999 54 : 590 6.
35. Gibbs DF, Shanley TP, Warner RL, Murphy HS, Varani J, Johnson KJ. Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases. Am J Respir Cell Mol Biol 1999 20 : 1145 54.
36. Cox G, Jones JL, O'Byrne KJ. Matrix metalloproteinase 9 and the epidermal growth factor signal pathway in operable non-small cell lung cancer. Clin Cancer Res 2000 6 : 2349 55.
37. Belleguic C, Corbel M, Germain N, Léna H, Boichot E, Delaval PH, Lagente V. Increased release of matrix metalloproteinase-9 in the plasma of acute severe asthmatic patients. Clin Exp Allergy 2002 32 : 217 23.
38. Lechapt-Zalcman E, Coste A, d'Ortho MP, Frisdal E, Harf A, Lafuma C, Escudrier E. Increased expression of matrix metalloproteinase-9 in nasal polyps. J Pathol 2001 193 : 233 41.
39. Wenzel SE, Balzar S, Cundall M, Chu HW. Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair. J Allergy Clin Immunol 2003 111 : 1345 52.
40. Lemjabbar H, Gosset P, Lamblin C, Tillie I, Hartmann D, Wallaert B, Tonnel AB, Lafuma C. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med 1999 159 (Part 1) : 1298 307.
41. Watelet JB, Demetter P, Claeys C, Van Cauwenberge P, Cuvelier C, Bachert C. Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery. Laryngoscope 2005 115 : 56 61.
42. Sorsa T, Tjäderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, Mäntylä P. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006 38 : 306 21.
43. Watelet JB, Annicq B, van Cauwenberge P, Bachert C. Objective outcome after functional endoscopic sinus surgery: prediction factors. Laryngoscope 2004 114 : 1092 7.
44. Powell CA, Mealey BL, Deas DE, McDonnell HT, Moritz AJ. Post-surgical infections: prevalence associated with various periodontal surgical procedures. J Periodontol 2005 76 : 329 33.
45. Wang JE, Pettersen S, Stuestol JF, Wang YY, Foster SJ, Thiemermann C, Aasen AO, Bjørnland K. Peptidoglycan of S. aureus causes increased levels of matrix metalloproteinases in the rat. Shock 2004 22 : 376 9.