The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears

Veterinary Dermatology

Volumn 19, Issue 6, 2008, Pages 358-367

  Mentzer, Sarah E ^a   Sundberg, John P ^b   Awgulewitsch, Alexander ^c   Chao, Hanna H J ^a   Carpenter, Donald A ^a   Zhang, Wei Dong ^b   Rinchik, Eugene M ^a,e   You, Yun ^a,d  

^a OAK RIDGE NATIONAL LABORATORY   (United States)

^b JACKSON LABORATORY   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d BCMM   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN; HOXC4 PROTEIN, MOUSE;

ANIMAL; ARTICLE; CHROMOSOME INVERSION; CHROMOSOME MAP; EAR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; GROWTH, DEVELOPMENT AND AGING; HAIR; MALE; METABOLISM; MOLECULAR CLONING; MOUSE; MUTATION; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; CHROMOSOME MAPPING; CLONING, MOLECULAR; EAR; FEMALE; GENE EXPRESSION REGULATION; GENOTYPE; HAIR; HOMEODOMAIN PROTEINS; INVERSION, CHROMOSOME; MALE; MICE; MUTATION;

MUS;

EID: 54949087022     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2008.00709.x     Document Type: Article

References (43)

1. Bangham JW. Hairy ears Eh. Mouse Newsletter 1965 33 : 68.
2. Bangham JW. The mutant hairy ears, Eh, reported in MNL 33: 68 is homozygous lethal. Mouse Newsletter 1968 38 : 32.
3. Davisson MT, Roderick TH, Akeson EC, Hawes NL, Sweet HO. The hairy ears (Eh) mutation is closely associated with a chromosomal rearrangement in mouse chromosome 15. Genetic Research 1990 56 : 167 78.
4. Sundberg JP, Orlow SJ. The Hairy Ears (Eh) Mutation, chromosome 15. In : Sundberg JP, ed. Handbook of Mouse Mutations with Skin and Hair Abnormalities, Animal Models and Biomedical Tools. CRC Press, Inc., Boca Raton, FL, 1994 : 319 22.
5. Guenet JL. Aggregation chimeras between normal and recessive lethal genotypes. Mouse Newsletter 1978 58 : 67.
6. Sambrook J, Russell D. Molecular Cloning - A Laboratory Manual. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory, 2001 : 61 633.
7. Cai WW, Reneker J, Chow CW, Vaishnav M, Bradley A. An anchored framework BAC map of mouse chromosome 11 assembled using multiplex oligonucleotide hybridization. Genomics 1998 54 : 387 97.
8. Southard-Smith EM, Collins JE, Ellison JS et al. Comparative analyses of the dominant megacolon-SOX10 genomic interval in mouse and human. Mammalian Genome 1999 10 : 744 9.
9. Robertson EJ. Embryo-derived stem cell lines. In : Robertson EJ, ed. Teratocarcinoma and Embryonic Stem Cells: A Practical Approach. Oxford : IRL Press, 1987 : 17 39.
10. Chick WS, Mentzer SE, Carpenter DA, Rinchik EM, You Y. Modification of an existing chromosomal inversion to engineer a balancer for mouse chromosome 15. Genetics 2004 167 : 889 95.
11. Letts VA, Valenzuela A, Kirley JP, Sweet HO, Davisson MT, Frankel WN. Genetic and physical maps of the stargazer locus on mouse chromosome 15. Genomics 1997 43 : 62 8.
12. Seymour RE, Ichiki T, Mikaelian I, Boggess D, Silva KA, Sundberg JP. Necropsy methods. In : Hedrich HJ, ed. The Laboratory Mouse. Heidelberg, Germany : Elsevier Academic Press, 2004 : 495 516.
13. Mecklenburg L, Paus R, Halata Z, Bechtold LS, Fleckman P, Sundberg JP. FOXN1 is critical for onycholemmal terminal differentiation in nude (Foxn1nu) mice. Journal of Investigative Dermatology 2004 123 : 1001 11.
14. Mikaelian I, Nanney LB, Parman KS et al. Antibodies that label paraffin-embedded mouse tissues: a collaborative endeavor. Toxicologic Pathology 2004 32 : 1 11.
15. Sundberg JP, King LEJ. Skin and its appendages: normal anatomy and pathology of spontaneous, transgenic, and targeted mouse mutations. In : Ward JM, Mahler JF, Maronpot RR, Sundberg JP, Frederickson RM, eds. Pathology of Genetically Engineered Mice. Ames, IA : Iowa State Press, 2000 : 183 216.
16. Kent WJ. BLAT-the BLAST-like alignment tool. Genome Research 2002 12 : 656 64.
17. Ball S, Peters J. Koala, a dominant mutation. Mouse Newsletter 1989 83 : 163 4.
18. Peters J, Tease C, Ball S. Koala, Koa, is associated with an inversion on mouse chromosome 15. Genetic Research 1992 59 : 237 8.
19. Fantauzzo KA, Tadin-Strapps M, You Y et al. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Human Molecular Genetics 2008 17 : 3539 51.
20. Katayama K, Furuno A, Miyamoto S, Nakamura M, Ojika I, Shinkai Y, Akiyama K, Tsuji T, Kunieda T. Suppressed recombination on mouse chromosome 15 defined regions of chromosomal inversions associated with koala (koa) and hairy ears (eh) mutations. Experimental animals 2008 57 : 73 7.
21. Hebert JM, Rosenquist T, Gotz J, Martin GR. FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutations. Cell 1994 78 : 1017 25.
22. Sundberg JP, Rourk MH, Boggess D, Hogan ME, Sundberg BA, Bertolino AP. Angora mouse mutation: altered hair cycle, follicular dystrophy, phenotypic maintenance of skin grafts, and changes in keratin expression. Veterinary Pathology 1997 34 : 171 9.
23. Lettice LA, Heaney SJ, Purdie LA et al. A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Human Molecular Genetics 2003 12 : 1725 35.
24. Nobrega MA, Ovcharenko I, Afzal V, Rubin EM. Scanning human gene deserts for long-range enhancers. Science 2003 302 : 413.
25. Qin Y, Kong LK, Poirier C, Truong C, Overbeek PA, Bishop CE. Long-range activation of Sox9 in odd sex (Ods) mice. Human Molecular Genetics 2004 1213 18.
26. West AG, Fraser P. Remote control of gene transcription. Human Molecular Genetics 2005 14 Spec No 1 : R101 11.
27. Kleinjan DA, van Heyningen V. Long-range control of gene expression: emerging mechanisms and disruption in disease. American Journal of Human Genetics 2005 76 : 8 32.
28. Velagaleti GV, Bien-Willner GA, Northup JK et al. Position effects due to chromosome breakpoints that map approximately 900 Kb upstream and approximately 1.3 Mb downstream of SOX9 in two patients with campomelic dysplasia. American Journal of Human Genetics 2005 76 : 652 62.
29. Calhoun VC, Levine M. Coordinate regulation of an extended chromosome domain. Cell 2003 113 : 278 80.
30. Spitz F, Gonzalez F, Duboule D. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 2003 113 : 405 17.
31. Spitz F, Herkenne C, Morris MA, Duboule D. Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes. Nature Genetics 2005 37 : 889 93.
32. Graham A, Papalopulu N, Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell 1989 57 : 367 78.
33. Awgulewitsch A. Hox in hair growth and development. Naturwissenschaften 2003 90 : 193 211.
34. Bieberich CJ, Ruddle FH, Stenn KS. Differential expression of the Hox 3.1 gene in adult mouse skin. Annals of the New York Academy of Sciences 1991 642 : 346 53.
35. Godwin AR, Capecchi MR. Hoxc13 mutant mice lack external hair. Genes and Development 1998 12 : 11 20.
36. Tkatchenko AV, Visconti RP, Shang L et al. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia. Development 2001 128 : 1547 58.
37. Lewis EB. A gene complex controlling segmentation in Drosophila. Nature 1978 276 : 565 70.
38. Papageorgiou S. A cluster translocation model may explain the collinearity of Hox gene expressions. Bioessays 2004 26 : 189 95.
39. Reid AI, Gaunt SJ. Colinearity and non-colinearity in the expression of Hox genes in developing chick skin. International Journal of Developmental Biology 2002 46 : 209 15.
40. Suemori H, Noguchi S. Hox C cluster genes are dispensable for overall body plan of mouse embryonic development. Developmental Biology 2000 220 : 333 42.
41. Capecchi MR. Function of homeobox genes in skeletal development. Annals of the New York Academy of Sciences 1996 785 : 34 7.
42. Cormier SA, Mello MA, Kappen C. Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro. BMC Developmental Biology 2003 3 : 4.
43. Sundberg JP. The angora (go) mutation, chromosome 5. In : Sundberg JP, ed. Handbook of Mouse Mutations with Skin and Hair Abnormalities, Animal Models and Biomedical Tools. Boca Raton, Florida : CRC Press, Inc., 1994 : 165 70.