Function of homeobox genes in skeletal development

Annals of the New York Academy of Sciences

Volumn 785, Issue , 1996, Pages 34-37

  Capecchi, Mario R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DEVELOPMENT; CELL PROLIFERATION; CONFERENCE PAPER; DNA SEQUENCE; GENE FUNCTION; GENE MUTATION; GENETIC LINKAGE; HOMEOBOX; HOMOZYGOTE; LIMB DEVELOPMENT; NONHUMAN; SPINE;

EID: 0029767416     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb56241.x     Document Type: Conference Paper

References (11)

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2. DAVIS, A. P. & M. R. CAPECCHI. 1994. Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11. Development 120: 2187-2198.
3. DOLLÉ, P., A. DIERICH, M. LE MEUR, T. SCHIMMANG, B. SCHUHBAUR, P. CHAMBON & D. DUBOULE. 1993. Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75: 431-441.
4. DAVIS, A. P., D. P. WITTE, H. M. HSIEH-LI, S. S. POTTER & M. R. CAPECCHI. 1995. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 375: 791-796.
5. CONDIE, B. G. & M. R. CAPECCHI. 1993. Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development 119: 579-595.
6. RAMIREZ-SOLIS, R., H. ZHENG, J. WHITING, R. KRUMLAUF & A. BRADLEY. 1993. Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell 73: 279-294.
7. JEANNOTTE, L., M. LEMIEUX, J. CHARRON, F. POIRIER & E. J. ROBERTSON. 1993. Specification of axial identity in the mouse: Role of the Hoxa-5 (Hox-1.3) gene. Genes Dev. 7: 2085-2096.
8. KOSTIC, D. & M. R. CAPECCHI. 1994. Targeted disruptions of the murine hoxa-4 and hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech. Dev. 46: 231-247.
9. HORAN, G. S. B., E. NAGY-KOVACS, R. R. BEHRINGER & M. S. FEATHERSTONE. 1995. Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function. Dev. Biol. 169: 359-372.
10. CONDIE, B. G. & M. R. CAPECCHI. 1994. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature 370: 304-307.
11. CHISAKA, O. & M. R. CAPECCHI. 1991. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature 350: 473-479.