Directed overexpression of insulin in Leydig cells causes a progressive loss of germ cells

Molecular and Cellular Endocrinology

Volumn 295, Issue 1-2, 2008, Pages 79-86

  Shirneshan, Katayoon ^a   Binder, Stefan ^a   Böhm, Detlef ^a   Wolf, Stephan ^a   Sancken, Ulrich ^a   Meinhardt, Andreas ^b   Schmid, Michael ^c   Engel, Wolfgang ^a   Adham, Ibrahim M ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Insl3; Insulin; Transgenic mice

Indexed keywords

C PEPTIDE; INSULIN; PROINSULIN;

3' UNTRANSLATED REGION; AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; DIABETES MELLITUS; EXPERIMENTAL MODEL; FEMALE; GENE; GENE OVEREXPRESSION; GERM CELL; HUMAN; HUMAN CELL; INSL3 GENE; LEYDIG CELL; MALE; MALE FERTILITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POSTNATAL DEVELOPMENT; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; SPERMATOGENESIS; SUBFERTILITY; TRANSGENE;

3' UNTRANSLATED REGIONS; AGE FACTORS; ANIMALS; BLOOD GLUCOSE; C-PEPTIDE; DIABETES MELLITUS, EXPERIMENTAL; HOMEODOMAIN PROTEINS; HUMANS; INFERTILITY, MALE; INSULIN; LEYDIG CELLS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PAIRED BOX TRANSCRIPTION FACTORS; PROINSULIN; PROMOTER REGIONS, GENETIC; PROTEINS; SPERMATOZOA; TIME FACTORS; UP-REGULATION;

EID: 54849430324     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2008.07.007     Document Type: Article

References (32)

1. Abai A.M., Hobart P.M., and Barnhart K.M. Insulin delivery with plasmid DNA. Hum. Gene Ther. 10 (1999) 2637-2649
2. Adham I.M., Burkhardt E., Benahmed M., and Engel W. Cloning of a cDNA for a novel insulin-like hormone of the testicular Leydig cells. J. Biol. Chem. 268 (1993) 26668-26672
3. Adham I.M., Steding G., Thamm T., Bullesbach E.E., Schwabe C., Paprotta I., and Engel W. The overexpression of the insl3 in female mice causes descent of the ovaries. Mol. Endocrinol. 16 (2002) 244-252
4. Baccetti B., La Marca A., Piomboni P., Capitani S., Bruni E., Petraglia F., and De Leo V. Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality. Hum. Reprod. 17 (2002) 2673-2677
5. Balvers M., Spiess A.N., Domagalski R., Hunt N., Kilic E., Mukhopadhyay A.K., Hanks E., Charlton H.M., and Ivell R. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139 (1998) 2960-2970
6. Bartlett R.J., Secore S.L., Denis M., Fernandez L., Tzakis A., Alejandro R., and Ricordi C. Toward the biologic release of human insulin from skeletal muscle. Transplant Proc. 29 (1997) 2199-2200
7. Bochan M.R., Shah R., Sidner R.A., and Jindal R.M. Reversal of diabetes in the rat by injection of hematopoietic stem cells infected with recombinant adeno-associated virus containing the preproinsulin II gene. Transplant Proc. 31 (1999) 690-691
8. Boehm D., Herold S., Kuechler A., Liehr T., and Laccone F. Rapid detection of subtelomeric deletion/duplication by novel real-time quantitative PCR using SYBR-green dye. Hum. Mutat. 23 (2004) 368-378
9. Brüning J.C., Gautam D., Burks D.J., Gillette J., Schubert M., Orban P.C., Klein R., Krone W., Müller-Wieland D., and Kahn C.R. Role of brain insulin receptor in control of body weight and reproduction. Science 289 (2000) 2122-2125
10. Büllesbach E.E., and Schwabe C. The primary structure and the disulfide links of the bovine relaxin-like factor (RLF). Biochemistry 41 (2002) 274-281
11. Cheung A.T., Dayanandan B., Lewis J.T., Korbutt G.S., Rajotte R.V., Bryer-Ash M., Boylan M.O., Wolfe M.M., and Kieffer T.J. Glucose-dependent insulin release from genetically engineered K cells. Science 290 (2000) 1959-1962
12. Goldfine I.D., German M.S., Tseng H.C., Wang J., Bolaffi J.L., Chen J.W., Olson D.C., and Rothman S.S. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat. Biotechnol. 15 (1997) 1378-1382
13. Hombach-Klonisch S., Schön J., Kehlen A., Blottner S., and Klonisch T. Seasonal expression of INSL3 and Lgr8/Insl3 receptor transcripts indicates variable differentiation of Leydig cells in the roe deer testis. Biol. Reprod. 71 (2004) 1079-1087
14. Kakoki M., Tsai Y.S., Kim H.S., Hatada S., Ciavatta D.J., Takahashi N., Arnold L.W., Maeda N., and Smithies O. Altering the expression in mice of genes by modifying their 3′ regions. Dev. Cell. 6 (2004) 597-606
15. Kelly R.B. Pathway of protein secretion in eukaryotes. Science 230 (1985) 25-32
16. Kolodka T.M., Finegold M., Moss L., and Woo S.L. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc. Natl. Acad. Sci. U.S.A 92 (1995) 3293-3297
17. Koskimies P., Levallet J., Sipila P., Huhtaniemi I., and Poutanen M. Murine relaxin-like factor promoter: functional characterization and regulation by transcription factors steroidogenic factor 1 and DAX-1. Endocrinology 143 (2002) 909-919
18. Koskimies P., Suvanto M., Nokkala E., Huhtaniemi I.T., McLuskey A., Themmen A.P., and Poutanen M. Female mice carrying a ubiquitin promoter-Insl3 transgene have descended ovaries and inguinal hernias but normal fertility. Mol. Cell. Endocrinol. 206 (2003) 159-166
19. Lipes M.A., Cooper E.M., Skelly R., Rhodes C.J., Boschetti E., Weir G.C., and Davalli A.M. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. U.S.A 93 (1996) 8595-8600
20. Lu Y.-C., Sternini C., Rozengurt E., and Zhukova E. Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes. Endocrinology 146 (2005) 2610-2619
21. Nef S., and Parada L.F. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 22 (1999) 295-299
22. Oyadomari S., Koizumi A., Takeda K., Gotoh T., Akira S., Araki E., and Mori M. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 109 (2002) 525-532
23. Rane S.G., Dubus P., Mettus R.V., Galbreath E.J., Boden G., Reddy E.P., and Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat. Genet. 22 (1999) 44-52
24. Remuzzi G., Ruggeneti P., and Mauer S.M. Pancreas and kidney/pancreas transplants:experimental medicine or real improvement?. Lancet 343 (1994) 27-31
25. Rhodes C.J., and Halban P.A. Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic β-cells predominantly via a regulated, rather than a constitutive, pathway. J. Cell Biol. 105 (1987) 145-153
26. Ross J. mRNA stability in mammalian cells. Microbiol. Rev. 59 (1995) 423-450
27. Sosa-Pineda B., Chowdhury K., Torres M., Oliver G., and Gruss P. The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas. Nature 386 (1997) 399-402
28. Steiner D.F. The proprotein convertases. Curr. Opin. Chem. Biol. 2 (1998) 31-39
29. Valera A., Fillat C., Costa C., Sabater J., Visa J., Pujol A., and Bosch F. Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J. 8 (1994) 440-447
30. Zimmermann S., Schottler P., Engel W., and Adham I.M. Mouse Leydig insulin-like (Ley I-L) gene: structure and expression during testis and ovary development. Mol. Reprod. Dev. 47 (1997) 30-38
31. Zimmermann S., Schwarzler A., Buth S., Engel W., and Adham I.M. Transcription of the Leydig insulin-like gene is mediated by steroidogenic factor-1. Mol. Endocrinol. 12 (1998) 706-713
32. Zimmermann S., Steding G., Emmen J.M., Brinkmann A.O., Nayernia K., Holstein A.F., Engel W., and Adham I.M. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13 (1999) 681-691