Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality

Human Reproduction

Volumn 17, Issue 10, 2002, Pages 2673-2677

  Baccetti, Baccio ^a,b   La Marca, Antonio ^a   Piomboni, Paola ^a,b   Capitani, Serena ^a,b   Bruni, Emanuele ^a,b   Petraglia, Felice ^a   De Leo, Vincenzo ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b CNR   (Italy)

Author keywords

Diabetes; GnRH; Hypothalamus pituitary testicular axis; Infertility; Sperm structure

Indexed keywords

FOLLITROPIN; GONADORELIN; GONADOTROPIN; INSULIN; LUTEINIZING HORMONE;

ADULT; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG RESPONSE; EJACULATION; ELECTRON MICROSCOPE; GONADOTROPIN RELEASE; HUMAN; HYPOPHYSIS DISEASE; HYPOTHALAMUS FUNCTION DISORDER; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MALE INFERTILITY; QUALITY CONTROL; RADIOIMMUNOASSAY; REPRODUCTIVE HEALTH; SEMEN ABNORMALITY; SEMEN ANALYSIS; SPERM; SPERMATOGENESIS; SPERMATOZOON DENSITY; SPERMATOZOON MATURATION; SPERMATOZOON MOTILITY; STATISTICAL SIGNIFICANCE; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0036799321     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/17.10.2673     Document Type: Article

References (31)

1. Adashi, E.Y., Hsueh, A.J. and Yen, S.S. (1981) Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells. Endocrinology, 108, 1441-1449.
2. Ali, S.T., Shaikh, R.N., Siddiqi, N.A. and Siddiqi, P.Q. (1993) Semen analysis in insulin-dependent/non-insulin-dependent diabetic men with/without neuropathy. Arch. Androl., 30, 47-54.
3. Baccetti, B., Bernieri, G., Burrini, A.G., Collodel, G., Crisa, N., Mirolli, M., Moretti, E. and Piomboni, P. (1995) Notulae seminologicae. 5. Mathematical evaluation of interdependent submicroscopic sperm alterations. J. Androl., 16 356-371.
4. Bestetti, G. and Rossi, G.L. (1982) Hypothalamic changes in diabetic Chinese hamsters. A semiquantitative, light and electron microscopic study. Lab. Invest., 47, 516-522.
5. Bestetti, G., Locatelli, V., Tirone, F., Rossi, G.L. and Muller, E.E. (1985) One month of streptozotocin-diabetes induces different neuroendocrine and morphological alterations in the hypothalamo-pituitary axis of male and female rats. Endocrinology, 117, 208-216.
6. Daubresse, J.C., Meunier, J.C., Wilmotte, J., Luyckx, A.S. and Lefebvre, P.J. (1978) Pituitary-testicular axis in diabetic men with and without sexual impotence. Diabet. Metab., 4, 233-237.
7. Distiller, L.A., Sagel, J., Morley, J.E. and Seftel, H.C. (1975) Pituitary responsiveness to luteinizing hormone-releasing hormone in insulin-dependent diabetes mellitus. Diabetes, 24, 378-380.
8. Djursing, H., Hagen, C., Nyholm, H.C., Carstensen, L. and Andersen, A.N. (183) Gonadotropin responses to gonadotropin-releasing hormone and prolactin responses to thyrotropin-releasing hormone and metoclopramide in women with amenorrhea and insulin-treated diabetes mellitus. J. Clin. Endocrinol. Metab., 56, 1016-1021.
9. Djursing, H., Carstensen, L., Hagen, C. and Andersen, A.N. (1984) Possible altered dopaminergic modulation of pituitary function in normal-menstruating women with insulin dependent diabetes mellitus (IDDM). Acta Endocrinol. (Copenh.), 107, 450-455.
10. Dong, Q., Lazarus, R.M., Wong, L.S., Vellios, M. and Handelsman, D.J. (1991) Pulsatile LH secretion in streptozotocin-induced diabetes in the rat. J. Endocrinol., 131, 49-55.
11. Garris, D.R., Williams, S.K., Coleman, D.L. and Morgan, C.R. (1984) Glucose utilization by the mouse brain: influence of age and diabetes. Brain. Res., 317, 141-146.
12. Gentry, R.T., Wade, G.N. and Blaustein, J.D. (1977) Binding of [3H]estradiol by brain cell nuclei and female rat sexual behavior: inhibition by experimental diabetes. Brain Res., 135, 135-146.
13. Gondos, B. and Bevier, W. (1995) Effect of insulin on testicular alterations in the nonobese diabetic mouse. Ann. Clin. Lab. Sci., 25, 272-277.
14. Goodner, C.J. and Freinkel, N. (1961) Studies of anterior pituitary tissue in vitro: effects of insulin and experimental diabetes mellitus upon carbohydrate metabolism. J. Clin. Endocrinol. Metab., 40, 261-272.
15. Handelsman, D.J., Conway, A.J., Boylan, L.M., Yue, D.K. and Turtle, J.R. (1985) Testicular function and glycemic control in diabetic men. A controlled study. Andrologia, 17, 488-496.
16. Johnson, L.M. and Sidman, R.L. (1979) A reproductive endocrine profile in the diabetes (db) mutant mouse. Biol. Reprod., 20, 552-559.
17. Kirchick, H.J., Keyes, P.L. and Frye, B.E. (1979), An explanation for anovulation in immature alloxan-diabetic rats treated with pregnant mare's serum gonadotropin: reduced pituitary response to gonadotropin-releasing hormone. Endocrinology, 105, 1343-1349.
18. la Marca, A., Morgante, G. and De Leo, V. (1999) Evaluation of hypothalamic-pituitary-adrenal axis in amenorrhoeic women with insulin-dependent diabetes. Hum. Reprod., 14, 298-302.
19. Makler, A. (1980) The improved ten-micrometer chamber for rapid sperm count and motility evaluation. Fertil. Steril., 33, 337-338.
20. Niven, M.J., Hitman, G.A. and Badenoch, D.F. (1995) A study of spermatozoal motility in type 1 diabetes mellitus. Diabet. Med., 12, 921-924.
21. Padron, R.S., Dambay, A., Suarez, R. and Mas, J. (1984) Semen analyses in adolescent diabetic patients. Acta Diabetol. Lat., 21, 115-121.
22. Press, M., Tamborlane, W.V., Thorner, M.O., Vale, W., Rivier, J., Gertner, J.M. and Sherwin, R.S. (1984) Pituitary response to growth hormone-releasing factor in diabetes. Failure of glucose-mediated suppression. Diabetes, 33, 804-806.
23. Rastogi, G.K., Chakraborti, J. and Sinha, M.K. (1974) Serum gonadotropins (LH and FSH) and their response to synthetic LHRH in diabetic men with and without impotence. Horm. Metab. Res., 6, 335-336.
24. Rossi, G.L. and Bestetti, G. (1981) Morphological changes in the hypothalamic-hypophyseal-gonadal axis of male rats after twelve months of streptozotocin-induced diabetes. Diabetologia, 21, 476-481.
25. Seethalakshmi, L., Menon, M. and Diamond, D. (1987) The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J. Urol., 138, 190-194.
26. South, S.A., Asplin, C.M.., Carlsen, E.C., Booth, R.A., Weltman, J.Y., Johnson, M.L., Veldhuis, J.D. and Evans, W.S. (1993) Alterations in luteinizing hormone secretory activity in women with insulin-dependent diabetes mellitus and secondary amenorrhea. J. Clin. Endocrinol. Metab., 76, 1048-1053.
27. Tanaka, T., Nagatani, S., Bucholtz, D.C., Ohkura, S., Tsukamura, H., Maeda, K. and Foster, D.L. (2000) Central action of insulin regulates pulsatile luteinizing hormone secretion in the diabetic sheep model. Biol. Reprod., 62, 1256-1261.
28. Vierhapper, H. (1985) LH-RH stimulated LH secretion in human endocrine disease. Acta Endocrinol., 269, S3-S25.
29. Vignon, F., Le Faou, A., Montagnon, D., Pradignac, A., Cranz, C., Winiszewsky, P. and Pinget, M. (1991) Comparative study of semen in diabetic and healthy men. Diabete Metab., 17, 350-354.
30. World Health Organization (1999) WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. 4th edn, Cambridge University Press, Cambridge, UK.
31. Wright, A.D., London, D.R., Holder, G., Williams, J.W. and Rudd, B.T. (1976) Luteinizing release hormone tests in impotent diabetic males. Diabetes, 25, 975-977.