Pre-steady-state kinetic studies establish entecavir 5′-triphosphate as a substrate for HIV-1 reverse transcriptase

Journal of Biological Chemistry

Volumn 283, Issue 9, 2008, Pages 5452-5459

  Domaoal, Robert A ^a   McMahon, Moira ^b   Thio, Chloe L ^b   Bailey, Christopher M ^a   Tirado Rives, Julian ^d   Obikhod, Aleksander ^c   Detorio, Mervi ^c   Rapp, Kimberly L ^c   Siliciano, Robert F ^b   Schinazi, Raymond F ^c   Anderson, Karen S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; KINETIC THEORY; VIRUSES;

BINDING AFFINITIES; CELL-BASED; CLINICAL OBSERVATIONS; DEOXYGUANOSINE; HEPATITIS B VIRUSES; HUMAN IMMUNODEFICIENCY VIRUSES; HUMAN LYMPHOCYTES; INCORPORATION RATES; INFECTED PATIENTS; KINETIC ASSAYS; KINETIC STUDIES; MOLECULAR LEVELS; POTENT INHIBITORS; REVERSE TRANSCRIPTASE; REVERSE TRANSCRIPTASE INHIBITORS; TRIPHOSPHATE; WILD TYPES;

ANIMAL CELL CULTURE;

ENTECAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; ANTIVIRUS AGENT; DRUG DERIVATIVE; GUANINE; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG BINDING; HEPATITIS B; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KINETICS; LYMPHOCYTE; MIXED INFECTION; PRIORITY JOURNAL; STEADY STATE; VIRUS REPLICATION; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HEPATITIS B VIRUS; METABOLISM; MISSENSE MUTATION; VIROLOGY;

HEPATITIS B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; CELLS, CULTURED; DRUG RESISTANCE, VIRAL; GUANINE; HEPATITIS B; HEPATITIS B VIRUS; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; LYMPHOCYTES; MUTATION, MISSENSE; VIRUS REPLICATION;

EID: 41949114325     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707834200     Document Type: Article

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