One-year chronic toxicity of madder color in F344 rats - Induction of preneoplastic/neoplastic lesions in the kidney and liver

Food and Chemical Toxicology

Volumn 46, Issue 10, 2008, Pages 3303-3310

  Inoue, Kaoru ^a   Shibutani, Makoto ^a   Masutomi, Naoya ^a   Toyoda, Kazuhiro ^a   Takagi, Hironori ^a   Takahashi, Miwa ^a   Fujimoto, Hitoshi ^a   Hirose, Masao ^a,b   Nishikawa, Akiyoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Food Safety Commission of Japan   (Japan)

Author keywords

Chronic toxicity; F344 rats; Kidney; Liver; Madder color; Rubia tinctorum L.

Indexed keywords

FOOD DYE; GLUTATHIONE TRANSFERASE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HEMATOLOGY; HISTOPATHOLOGY; HYPERPLASIA; KIDNEY ADENOMA; KIDNEY INJURY; KIDNEY MASS; KIDNEY PROXIMAL TUBULE; LIVER INJURY; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; RAT; RUBIA; WEIGHT CHANGE;

ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; KIDNEY; KIDNEY NEOPLASMS; LIVER NEOPLASMS; MALE; PLANT EXTRACTS; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; RUBIA; TOXICITY TESTS, CHRONIC;

RATTUS; RUBIA TINCTORUM;

EID: 54849375900     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.07.025     Document Type: Article

References (23)

1. Asanoma M., Miyabe M., and Sakabe Y. Mutagenicity of natural food additives in Salmonella typhimurium. Report No. II. Annual Report of Nagoya City Public Health Research Institute 30 (1984) 53-57 (in Japanese)
2. Blömeke B., Poginsky B., Schmutte C., Marquardt H., and Westendorf J. Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L. Mutation Research 265 (1992) 263-272
3. Brown J.P., and Dietrich P.S. Mutagenicity of anthraquinone and benzanthrone derivatives in the Salmonella/microsome test: activation of anthraquinone glycosides by enzymic extracts of rat cecal bacteria. Mutation Research 66 (1979) 9-24
4. Fleischman R.W., Esber H.J., Hagopian M., Lilja H.S., and Huff J. Thirteen-week toxicology studies of 1-amino-2,4-dibromoanthraquinone in Fischer 344/N rats and B6C3F1 mice. Toxicology and Applied Pharmacology 82 (1986) 389-404
5. Gorner H. Photoreactions of p-benzo-, p-naphtho- and p-anthraquinones with ascorbic acid. Photochemical and Photobiological Sciences 3 (2004) 933-938
6. Hachiya N., Takizawa Y., Kawamura T., Tateno T., Sakabe Y., Asanoma M., Noda M., Ishizaki M., Ishibashi T., and Kuroda K. A review of acute toxicity and genotoxicity data on natural food additives. Toxicology Forum 8 (1985) 91-105 (in Japanese)
7. Hagiwara A., Kawabe M., Tanaka H., Kokubo Y., Sano M., Tamano S., Kadota T., Nakamura M., and Imada K. Two different constituents of madder colors lack tumor promoting or carcinogenic potential in a medium-term multi-organ carcinogenesis bioassay in rats. Japanese Journal of Food Chemistry 4 (1997) 99-106
8. IARC (International Agency for Research on Cancer). Some traditional herbal medicine, C. Rubia Tinctorum, Morinda Officinalis and anthraquinones. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. vol. 82 Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene (2002), IARC Press, Lyon, France 129-151
9. Imaida K., Tatematsu M., Kato T., Tsuda H., and Ito N. Advantages and limitations of stereological estimation of placental glutathione S-transferase-positive rat liver cell foci by computerized three-dimensional reconstruction. Japanese Journal of Cancer Research 80 (1989) 326-330
10. Inoue K., Shibutani M., Masutomi N., Toyoda K., Takagi H., Uneyama C., Nishikawa A., and Hirose M. A 13-week subchronic toxicity study of madder color in F344 rats. Food and Chemical Toxicology 46 (2008) 241-252
11. Ishidate Jr. M., Sofuni T., Yoshikawa K., Hayashi M., Nohmi T., Sawada M., and Matsuoka A. Primary mutagenicity screening of food additives currently used in Japan. Food and Chemical Toxicology 22 (1986) 623-636
12. Ito N., Imaida K., Asamoto M., and Shirai T. Early detection of carcinogenic substances and modifiers in rats. Mutation Research 462 (2000) 209-217
13. Kawasaki Y., Goda Y., and Yoshihira K. The mutagenic constituents of Rubia tinctorum. Chemical and Pharmaceutical Bulletin 40 (1992) 1504-1509
14. Marec F., Kollarova I., and Jegorov A. Mutagenicity of natural anthraquinones from Rubia tinctorum in the drosophila wing spot test. Planta Medica 67 (2001) 127-131
15. MHLW (Ministry of Health, Labour and Welfare of Japan). List of existing food additives. Foods and Food Ingredients (Editorial) 166 (1995) 93-101 (in Japanese)
16. Poginsky B., Westendorf J., Blomeke B., Marquardt H., Hewer A., Grover P.L., and Phillips D.H. Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L. Carcinogenesis 12 (1991) 1265-1271
17. Potter C.L., Chang L.W., DeAngelo A.B., and Daniel F.B. Effects of four trihalomethanes on DNA strand breaks, renal hyaline droplet formation and serum testosterone in male F-344 rats. Cancer Letters 106 (1996) 235-242
18. Shirai T. A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential, a historical review of model development and summary of results from 291 tests. Toxicologic Pathology 25 (1997) 453-460
19. Tajiri K., Miyakawa H., Marumo F., and Sato C. Increased renal susceptibility to gentamicin in the rat with obstructive jaundice. Role of lipid peroxidation. Digestive Diseases and Sciences 40 (1995) 1060-1064
20. Westendorf J., Poginsky B., Marquardt H., Groth G., and Marquardt H. The genotoxicity of lucidin, a natural component of Rubia tinctorum L. and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biology and Toxicology 4 (1988) 225-239
21. Westendorf J., Marquardt H., Poginsky B., Dominiak M., Schmidt J., and Marquardt H. Genotoxicity of naturally occurring hydroxyanthraquinones. Mutation Research 240 (1990) 1-12
22. Westendorf J., Pfau W., and Schulte A. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis 19 (1998) 2163-2168
23. Yasui Y., and Takeda N. Identification of a mutagenic substance, in Rubia tinctorum L. (madder) root, as lucidin. Mutation Research 121 (1983) 185-190