Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L.

Carcinogenesis

Volumn 19, Issue 12, 1998, Pages 2163-2168

  Westendorf, Johannes ^a   Pfau, Wolfgang ^b   Schulte, Agnes ^c  

^a University Medical School Hamburg Eppendorf   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c Fed Inst Hlth Protect C   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER RISK; CARCINOGENICITY; COLON; CONTROLLED STUDY; DIETARY INTAKE; DNA ADDUCT; FEMALE; HERBAL MEDICINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY INJURY; LIVER INJURY; MALE; MORBIDITY; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RAT; TIME; WEIGHT GAIN;

ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; KIDNEY; KIDNEY NEOPLASMS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; NEOPLASMS, EXPERIMENTAL; PLANT ROOTS; PLANTS, MEDICINAL; RATS; RATS, INBRED ACI; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 0032437644     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.12.2163     Document Type: Article

References (25)

1. Yasui,Y. and Takeda,N. (1983) Identification of a mutagenic substance in Rubia tinctorum L. (madder) root as lucidin. Mutat. Res., 121, 185-190.
2. Westendorf,J., Poginsky,B., Marquardt,H., Groth,G. and Marquardt,H. (1988) The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol. Toxicol., 4, 225-239.
3. Poginsky,B., Westendorf,J., Blömeke,B., Marquardt,H., Hewer,A., Grover,P. and Phillips,D. (1991) Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L. Carcinogenesis, 12, 1265-1271.
4. Poginsky,B. (1989) Vorkommen und Genotoxizität von Anthracenderivaten in Rubia tinctorum L. (Occurrence and genotoxicity of anthracene derivatives in Rubia tinctorum L.), Doctoral thesis, Hamburg.
5. Murti,V., Seshradi,T. and Sivakumaran,S. (1970) A study of madder, the roots of Rubia tinctorum Linn. Indian J. Chem., 8, 779-782.
6. Gupta,R.C. (1984) Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo. Proc. Natl Acad. Sci. USA, 81, 6943-6947.
7. Pfau,W., Brockstedt,U., Schulze,C., Neurath,G. and Marquardt,H. (1996) Characterization of the major DNA-adduct formed by the food mutagen 2-amino-3-methyl-9H-pyridol[2,3-b]indole (MeAC) in primary rat hepatocytes. Carcinogenesis, 17, 2727-2732.
8. 32P-labeled nucleoside 3′,5′-bisphosphate adducts of polycyclic aromatic hydrocarbons. J. Chromatogr, 570, 65-76.
9. 32P-post-labeling analysis of DNA adducts formed by food-derived heterocyclic amines: evidence for incomplete hydrolysis and a procedure for adduct simplification. Carcinogenesis, 15, 877-882.
10. 32P-postlabeling analysis of aromatic carcinogen-DNA adducts. Cancer Res., 45, 5656-5662.
11. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis, 7, 1543-1551.
12. Westendorf,J. (1993) Anthranoid-derivatives. In De Smet,P.A.G.M., Keller,K. Hänsel,R. and Chandler,R.F. (eds) Adverse Effects of Herbal Drugs. Springer-Verlag, Berlin, Germany, pp. 105-139.
13. Smith,B. (1973) Pathologic changes in the colon produced by anthraquinone purgatives. Dis. Colon Rectum, 16, 455-488.
14. Siegers,C.P. (1992) Anthranoid laxatives and colorectal cancer. Trends Phannacol. Sci., 13, 507-512.
15. Wijnsma,R. and Verpoorte,R. (1986) Anthraquinones in the Rubiaceae. Prog. Chem. Org. Nat. Prod., 49, 79-149.
16. Mori,H., Sugie,S., Niwa,K., Takahashi,M. and Kawai,K. (1985) Induction of intestinal tumors in rats by chrysazin. Br. J. Cancer, 52, 781-783.
17. Wölfle,D., Schmutte,C., Westendorf,J. and Marquardt,H. (1990) Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Cancer Res., 50, 6540-6544.
18. Gebhardt,M. (1979) Erste vorläufige Ergebnisse einer Studie über die lilholytische Wirksamkeit von Urol® auf Calciumoxalatsteine (Preliminary results of a study about the litholytic action of Urol® on calcium oxalate stones). Fortschr. Urol. Nephrol., 14 (suppl.), 34-40.
19. Bannasch,P, Zerhahn,H. and Hacker,H.J. (1985) Foci of altered hepatocytes, rat. In Jones,T.C., Mohr,U. and Popp,J.A. (eds) Digestive System. Springer Verlag, Berlin, Germany, pp. 10-30.
20. Eustis,S.L., Boormann,B.A., Harada,T. and Popp,J.A. (1990) Liver. In Boormann,G.A., Eustis,S.L., Helwell,M.R., Montgomery,C.A.Jr and McKenzie,W.F. (eds) Pathology of the Fisher Rat. Academic Press, London, UK, pp. 71-94.
21. Hedrich,H.J. (1990) Genetic Monitoring of Inbred Strains of Rats. Gustav Fischer Verlag, Stuttgart, Germany.
22. Mohr,U. (1992) Hyperplasia, tubular, kidney. In Mohr,U. (ed.) International Classification of Rodent Tumors. Part 1 : The Rat. Urinary System. IARC Scientific Publications No. 122. IARC, Lyon, pp. 1-3.
23. Bannasch,P., Zerban,H. and Hacker,H.J. (1986) Oncocytoma, kidney, rat. In Jones,T.C., Mohr,U. and Hunt,R.D. (eds) Urinary System. Springer Verlag, Berlin, Germany, pp. 49-60.
24. Tsuda,H. and Krieg,K. (1992) Neoplastic lesions of the kidney. In Mohr,U., Dungworth,D.L. and Capen,C.C. (eds) Pathobiology of the Aging Rat. ISL Press, Washington, DC, pp. 227-240.
25. 1 mice. Toxicol. Ind. Health, 11, 449-458.