Novel triple neurokinin receptor antagonist CS-003 inhibits respiratory disease models in guinea pigs

European Journal of Pharmacology

Volumn 596, Issue 1-3, 2008, Pages 153-159

  Tsuchida, Hiroshi ^a   Takahashi, Sakiko ^a   Nosaka, Emi ^a   Kuraya, Takako ^a   Yamashita, Makoto ^a   Morimoto, Kiyoshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Asthma; Cigarette smoke; Cough; CS 003; Rhinitis; Triple neurokinin receptor antagonist

Indexed keywords

[1 {2 [(2R) (3,4 DICHLOROPHENYL) 4 (3,4,5 TRIMETHOXYBENZOYL)MORPHOLIN 2 YL]ETHYL}SPIRO[BENZO[C]THIOPHENE 1(3H),4' PIPERIDINE] (2S) OXIDE; ANTITUSSIVE AGENT; CAPSAICIN; CIGARETTE SMOKE; CODEINE; CS 003; DEXAMETHASONE; METHACHOLINE CHLORIDE; MONTELUKAST; NEUROKININ A; NEUROKININ B; OVALBUMIN; SUBSTANCE P; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; COUGHING; DOSE RESPONSE; GUINEA PIG; MUCUS SECRETION; NEUROGENIC INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; TRACHEAL BLOOD VESSEL;

ADMINISTRATION, ORAL; ANIMALS; ASTHMA; BRONCHOCONSTRICTION; CAPILLARY PERMEABILITY; CAPSAICIN; COUGH; CYCLIC S-OXIDES; DISEASE MODELS, ANIMAL; GUINEA PIGS; MALE; MORPHOLINES; MUCUS; OVALBUMIN; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, TACHYKININ; RESPIRATORY TRACT DISEASES; RHINITIS; SMOKE; TOBACCO; TRACHEA;

EID: 54849373500     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.07.046     Document Type: Article

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