Pre-protachykinin-A mRNA is increased in the airway epithelium of smokers with chronic bronchitis

Respirology

Volumn 6, Issue 3, 2001, Pages 187-197

  Reynolds, Paul N ^a,b   Scicchitano, Raffaele ^a   Holmes, Mark D ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b University of Alabama at Birmingham   (United States)

Author keywords

Airway epithelium; Brush biopsy; Chronic bronchitis; Receptors; Substance P; Tachykinins

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; NEUROKININ 1 RECEPTOR; PREPROTACHYKININ; PREPROTACHYKININ A; TACHYKININ; TACHYKININ RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHRONIC BRONCHITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING;

ACTINS; ADULT; AGED; BRONCHI; BRONCHITIS; BRONCHOSCOPY; CHRONIC DISEASE; EPITHELIUM; FEMALE; GENE EXPRESSION; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-8; MALE; MIDDLE AGED; NEPRILYSIN; PROTEIN PRECURSORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SMOKING; TACHYKININS;

EID: 0034822787     PISSN: 13237799     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1843.2001.00333.x     Document Type: Article

References (41)

1. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man
2. Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
3. Effects on the isolated human bronchus of SR 48968, a potent and selective nonpeptide antagonist of the neurokinin A (NK2) receptors
4. Substance P (NK1) receptor immunoreactivity on endothelial cells of the rat tracheal mucosa
5. Effects of tachykinins on mucus secretion in human bronchi in vitro
6. Induction of normal human eosinophil migration in vitro by substance P
7. Substance P increases neutrophil adhesion to bronchial epithelial cells
8. Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis
9. Tachykinin regulation of airway smooth muscle cell proliferation
10. Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo
11. Protective effect of substance P on permeability of airway epithelial cells in culture
12. Diversity in mammalian tachykinin peptidergic neurons: Multiple peptides, receptors, and regulatory mechanisms
13. Tachykinin receptors: A radioligand binding perspective
14. Substance P and beta-endorphin-like immunoreactivity in lavage fluids of subjects with and without allergic asthma
15. Elevated substance P content in induced sputum from patients with asthma and patients with chronic bronchitis
16. Asthma as an axon reflex
17. Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis
18. Effect of hyperoxia on substance P expression and airway reactivity in the developing lung
19. Neutral endopeptidase modulation of neurogenic inflammation in airways
20. A technique to harvest viable tracheobronchial epithelial cells from living human donors
21. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis
22. A serum-free method for culturing NHBE cells at clonal density
23. Isolation and characterisation of the human lung NK-1 receptor cDNA
24. Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends
25. The primary structure and gene organization of human substance P and neuromedin K receptors
26. Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein
27. cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A
28. Structure, chromosome location, and expression of the human gamma-actin gene: Differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes
29. Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8
30. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester
31. HLA-DR and ICAM-1 expression on bronchial epithelial cells in asthma and chronic bronchitis
32. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells
33. Quantification and localization of HLA-DR and intercellular adhesion molecule- 1 (ICAM-1) molecules on bronchial epithelial cells of asthmatics using confocal microscopy
34. Neutral endopeptidase activity and airway hyperresponsiveness to neurokinin A in asthmatic subjects in vivo
35. Nedocromil sodium reduce cigarette smoke-induced bronchoconstrictor hyperresponsiveness to substance P in the guinea-pig
36. Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals
37. Autoradiographic mapping of substance P receptors in lung
38. Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases
39. Protection against bradykinin-induced bronchoconstriction in asthmatic patients by neurokinin receptor antagonist
40. The effect of inhaled FK224, a tachykinin NK-1 and NK-2 receptor antagonist, on neurokinin A-induced bronchoconstriction in asthmatics
41. A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients