Effects of one-year low-dose growth hormone (GH) therapy on body composition, lipid profile and carbohydrate metabolism in young adults with childhood-onset severe GH deficiency confirmed after completion of growth promotion

Endokrynologia Polska

Volumn 59, Issue 4, 2008, Pages 292-300

  Hilczer, Maciej ^a,b   Smyczyńska, Joanna ^a,b   Stawerska, Renata ^a,b   Lewiński, Andrzej ^a,b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

Body composition; Carbohydrate metabolism; GH therapy; Insulin resistance; Lipid profile; Quality of life; Severe GHD

Indexed keywords

CLONIDINE; GLUCAGON; GLUCOSE; GROWTH HORMONE; HEMOGLOBIN A1C; INSULIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ARTICLE; BODY COMPOSITION; BODY HEIGHT; BODY MASS; CARBOHYDRATE METABOLISM; CLINICAL TRIAL; DIET RESTRICTION; DISEASE SEVERITY; DRUG EFFICACY; DRUG INDICATION; DRUG RESPONSE; DRUG WITHDRAWAL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; GROWTH HORMONE RELEASE; HEMOGLOBIN BLOOD LEVEL; HORMONAL THERAPY; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID METABOLISM; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; OPTIMAL DRUG DOSE; PATIENT SELECTION; PROVOCATION TEST; QUALITY OF LIFE;

ADOLESCENT; BODY COMPOSITION; CARBOHYDRATE METABOLISM; CHILD; FEMALE; HUMAN GROWTH HORMONE; HUMANS; LIPID METABOLISM; MALE;

EID: 54749115183     PISSN: 0423104X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. de Boer H, Blok GJ, van der Veen EA. Clinical aspects of growth hormone deficiency in adults. Endocr Rev 1995; 16: 63-86.
2. Carroll PV, Christ ER, Bengtsson BA et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A Review J Clin Endocrinol Metab 1998; 83: 382-395.
3. Shalet SM, Toogood A, Rahim A et al. The Diagnosis of growth hormone deficiency in children and adults. Endocrine Reviews 1998; 19: 203-223.
4. Colao A, Di Somma C, Spiezia S et al. The natural history of partial growth hormone deficiency in adults: a prospective study on the cardiovascular risk and atherosclerosis. J Clin Endocrinol Metab 2006; 91: 2191-2200.
5. Tauber M, Moulin P, Pienkowski C et al. Growth hormone (GH) retesting and auxological data in 131 GH-deficient patients after completion of treatment. J Clin Endocrinol Metab 1997; 92: 352-356.
6. Juul A, Kastrup K, Pedersen S et al. Growth hormone provocative testing in 108 young adults with childhood onset GH deficiency and the diagnostic value of insulin-like growth factor 1 (IGF 1) and IGF binding protein-3. J Clin Endocrinol Metab 1997; 82: 1195-1201.
7. Maghnie M, Strigazzi C, Tinelli C et al. Growth hormone (GH) deficiency (GHD) of childhood onset: reassessment of GH status and evaluation of the predictive criteria for permanent GHD in young adults. J Clin Endocrinol Metab 1999; 84: 1324-1328.
8. Growth Hormone Research Society. Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 1998; 83: 379-381.
9. Abs R. Update on the diagnosis of GH deficiency in adults. Eur J Endocrinol 2003; 148: S3-S8.
10. Clayton PE, Cuneo RC, Juul A et al. Consensus statement on the management of the GH-treated adolescent in the transition to adult care. Eur J Endocrinol 2005; 152: 165-170.
11. Ho Ken HY. Consensus guidelines for the diagnosis and treatment of adults with GH deficiency II: a statement of the GH Research Society in association with the European Society for Pediatric Endocrinology, Lawson Wilkins Society, European Society of Endocrinology, Japan Endocrine Society, and Endocrine Society of Australia. Eur J Endocrinol 2007; 157: 695-700.
12. Aimaretti G, Corneli G, Razzore P et al. Comparison between insulin-induced hypoglycemia and Growth Hormone (GH)-Releasing Hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults. J Clin Endocrinol Metab 1998; 83: 1615-1618.
13. Maghnie M, Aimaretti G, Bellone S et al. Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement. Eur J Endocrinol 2005; 152: 589-596.
14. Moltich ME. Diagnosis of GH deficiency in adults - how good do the criteria need to be? J Clin Endocrinol Metab 2002; 87: 472-476.
15. Matthews DR, Hosker IP, Rudenski AS et al. Homeostasis model assessment insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in men. Diabetologia 1985; 28: 412-419.
16. Belfiore F, Ianello S, Camuto M et al. Insulin sensitivity of blood glucose versus insulin sensitivity of blood free fatty acids in normal, obese, and obese - diabetic subjects. Metabolism 2001; 50: 573-582.
17. Mc Kenna S, Doward L, Alonso J et al. The QoL-AGHDA: an instrument for to assess quality of life in adults with growth hormone deficiency. Qual Life Res 1999; 8: 373-383.
18. Tillmann V, Patel L, Gill MB et al. Monitoring serum insulin-like growth factor-1 (IGF 1), IGF binding protein-3) IGF 1/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth. Clin Endocrinol (Oxf) 2000; 53: 329-336.
19. Thomson R, Brinkworth GD, Buckley JD et al. Good agreement between bioelectrical impedance and dual-energy X-ray absorptiometry for estimating changes in body composition during weight loss in overweight young women. Clin Nutr 2007; 26: 771-777.
20. Svensson J, Finer N, Boulux P et al. Growth hormone (GH) replacement therapy in GH deficient Adults: Predictors of one-year metabolic and clinical response. Growth Horm & IGF Res 2007; 17: 67-76.
21. Boguszewski CL, Meister LHF, Zaninelli DCT et al. One year of GH replacement therapy with a fixed low-dose regimen improves body composition, bone mineral density and lipid profile of GH-deficient adults. Eur J Endocrinol 2005; 152: 67-75.
22. Simpson H, Savine R, Sonksen P et al. GRS Council Growth hormone replacement therapy for adults: into the new millennium. Growth Horm & IGF Res 2002; 12: 1-33.
23. Abrams P, Abs R. The lipid profile in adult hypopituitary patients with growth hormone deficiency. In: Growth hormone deficiency in adults: 10 years of KIMS Eds R Abs & U Feldt Rasmussen. Oxford: Oxford Pharmagenesis Ltd 2004; 127-138.
24. Gillberg P, Bramnert M, Thoren M et al. Commencing growth hormone replacement in adults with a fixed low dose. Effects on serum lipoproteins, glucose metabolism, body composition, and cardiovascular function. Growth Horm & IGF Res 2001; 11: 273-281.
25. Carroll PV, Drake WM, Maher KT et al. Comparison of continuation or cessation of growth hormone (GH) therapy on body composition and metabolic status in adolescents with severe GH deficiency at completion of linear growth. J Clin Endocrinol Metab 2004; 89: 3890-3895.
26. de Boer H, van der Veen E. Guidelines for optimizing growth hormone replacement therapy in adults. Horm Res 1997; 48: 21-30.
27. Bülow B, Erfurth EM. A low individualized GH dose in young patients with childhood onset GH deficiency normalized serum IGF 1 without significant deterioration in glucose tolerance. Clin Endocrionol 1999; 50; 45-55.
28. Giavolli C, Poretti S, Ronchi Cl et al. Long-term monitoring of insulin sensitivity in growth hormone-deficient adults on substitutive recombinant human growth hormone therapy. Metabolism 2004; 53: 740-743.