Influence of human recombinant interferon-α2a (rhIFN-α2a) on altered lymphocyte subpopulations and monocytes in Behçet's disease

Rheumatology

Volumn 43, Issue 10, 2004, Pages 1275-1282

  Treusch, M ^a   Vonthein, R ^a   Baur, M ^a   Gunaydin I ^a   Koch, S ^a   Stubiger N ^a   Eckstein, A K ^b   Peter, H H ^c   Ness, T ^c   Zierhut, M ^a   Kötter, Ina ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Beh et's disease; IFN ; Lymphocyte subpopulations

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CYCLOSPORIN A; HLA ANTIGEN CLASS 1; HLA B51 ANTIGEN; IMMUNOMODULATING AGENT; INTERLEUKIN 2 RECEPTOR; MONOCLONAL ANTIBODY; PREDNISOLONE; RECOMBINANT ALPHA2A INTERFERON;

ADULT; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE ACTIVATION; BEHCET DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INTERFERON INDUCTION; LYMPHOCYTE SUBPOPULATION; MALE; MEDICAL ASSESSMENT; NATURAL KILLER CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGENS, CD; B-LYMPHOCYTES; BEHCET SYNDROME; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HLA-B ANTIGENS; HUMANS; INTERFERON ALFA-2A; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; LEUKOCYTES, MONONUCLEAR; MALE; MONOCYTES; RECOMBINANT PROTEINS; T-LYMPHOCYTE SUBSETS;

EID: 5444274550     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keh311     Document Type: Article

References (40)

1. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990;335:1078-80.
2. Freysdottir J, Lau SH, Fortune F. γδ T cells in Behç et's disease (BD) and recurrent aphthous stomatitis (RAS). Clin Exp Immunol 1999;118:451-7.
3. Esin S, Gül A, Hdara V et al. Peripheral blood T cell expansions in patients with Behçet's disease. Clin Exp Immunol 1997;107:520-7.
4. Yamashita N, Kaneoka H, Kaneko S et al. Role of γδ T-lymphocytes in the development of Behçet's disease. Clin Exp Immunol 1997;107:241-7.
5. Fortune F, Walker J, Lehner T. The expression of γδ T cell receptor and the prevalence of primed, activated and IgA bound T cells in Behçet's syndrome. Clin Exp Immunol 1990;82:326-32.
6. Hasan A, Fortune F, Wilson A et al. Role of γδ T cells in pathogenesis and diagnosis of Behçet's disease. Lancet 1996;347:789-94.
7. Kaneko F, Takahashi Y, Muramatsu R et al. Natural killer cell numbers and function in peripheral lymphoid cells in Behçet's disease. Br J Dermatol 1985;113:313-18.
8. Suzuki Y, Hoshi K, Matsuda T, Mizushima Y. Increased peripheral blood γδ+ T cells and natural killer cells in Behçet's disease. J Rheumatol 1992;19:588-92.
9. Nakamura S, Sugita M, Matoba H, Tanaka SI, Isoda F, Ohno S. Insufficient expression of Fas antigen on helper T cells in Behç et's disease. Br J Ophthalmol 1996;80:174-6.
10. Sugi-Ikai N, Nakazawa M, Nakamura S, Ohno S, Minami M. Increased frequencies of interleukin 2 interferon γ-producing T cells in patients with active Behçet's disease. Invest Ophthalmol Vis Sci 1998;39:996-1004.
11. Zouboulis CC, Orfanos CE. Treatment of Adamantiades-Behçet's disease with systemic interferon alpha. Arch Dermatol 1998;134:1010-16.
12. Kötter I, Zierhut M, Eckstein AK et al. Human recombinant interferon-alfa-2a for the treatment of Behçet's disease with sight threatening posterior or panuveitis. Br J Ophthalmol 2003;87:423-31.
13. Belardelli P, Gresser I. The neglected role of type I interferon in the T cell response: Implications for its clinical use. Immunol Today 1996;17:369-72.
14. BenEzra D, Forrester JV, Nussenblatt RB et al. Uveitis Scoring System. Berlin: Springer, 1991.
15. + γδ T cells to Streptococcus sanguis in patients with Behçet's disease. Ocular Immunol Inflamm 1998;6:139-44.
16. + T cell subsets in Behçet's disease. Rheumatol Int 1999;19:23-6.
17. Sahin S, Lawrence R, Direskeneli H, Hamuryudan V, Yazici H, Akoglu T. Monocyte activity in Behçet's disease. Br J Rheumatol 1996;35:424-9.
18. Gül A, Esin S, Dilsen N, Konice M, Wigzell H, Biberfeld P. Immunohistology of skin pathergy reaction in Behçet's disease. Br J Dermatol 1995;132:901-7.
19. Metzger R, Heckl-Österreicher B, Nerl C, Schondelmaier S, Kabelitz D. Immunological studies of γδ T cells in a case of LGL-leukemia: leukemic γδ T cells are resistant to growth stimulation in vitro but respond to interferon α treatment in vivo. Leukemia Res 1992;16:1087-95.
20. Wejstal R, Norkrans G, Lenkei R, Wieland O, Schvarcz R, Frydén A. peripheral blood lymphocyte subsets in patients with chronic hepatitis C - effects of interferon treatment. Liver 1992; 12:161-7.
21. Bolay H, Karabudak R, Aybay C et al. Alpha interferon in myasthenia gravis: effects on natural killer cell activity. J Neuroimmunol 1998;82:109-15.
22. Malaponte G, Passero E, Leonardi S et al. Effect of alpha interferon on natural cell activity and lymphocyte subsets in thalassemia patients with chronic hepatitis C. Acta Haematol 1997;98:83-8.
23. Hunter CS, Gabriel KE, Radzanowski T, Neyer LE, Remington JS. Type I interferons enhance production of IFN-gamma by NK cells. Immunol Lett 1997;59:1-5.
24. Kaser A, Enrich B, Ludwiczek O, Vogel W, Tilg H. Interferon alpha enhances cytotoxicity in heathy volunteers and chronic hepatitis C infection mainly by the perforin pathway. Clin Exp Immunol 1999;118:71-7.
25. Corssmit EP, Heijlenberg R, Hack CE, Endert E, Sauerwein HP, Romijn JA. Effects of interferon alpha administration on leukocytes in healthy humans. Clin Exp Immunol 1997;107:359-63.
26. Kovesi G, Paloczi K, Onody K, Fekete B. Immunologic profile of patients suffering from herpes simplex virus (HSV)-associated oral lesions treated with natural human interferon alpha (egiferon). Pathol Oncol Res 1997;3:44-6.
27. Su L, David M. Inhibition of B cell receptor mediated apoptosis by interferon. J Immunol 1999;162:6317-21.
28. Cauli A, Dessole, G, Fiorillo MT et al. Increased level of HLA-B27 expression in ankylosing spondylitis patients compared with healthy HLA-B27 positive subjects: a possible further susceptibility factor for the development of disease. Rheumatology 2002;41:1375-9.
29. Müller CA, Walz J, Zinser R, Bühring HJ, Steinke B, Schmidt H. In vivo induction of HLA molecules in patients with myeloproliferative syndrome during interferon alpha treatment. Ann Haematol 1991;61:259-63.
30. Piazzolla G, Giannelli G, Antonelli G et al. Effects of interferon-alpha treatment on neutrophil oxidative metabolism, lymphocyte proliferation and monocyte HLA class I antigen expression in patients with chronic hepatitis C. Immunopharmacol Immunotoxicol 1996;18:529-48.
31. Fauci AS, Dale DC, Balow JE. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 1976;84:304-15.
32. Yocum DE, Wilder RL, Dougherty S, Klippel JH, Pilmer S, Wahl S. Immunologic parameters of response in patients with rheumatoid arthritis treated with cyclosporin A. Arthritis Rheum 1990;33: 1310-16.
33. Nowaczyk M, Gorski A, Maldyk M et al. Immune monitoring after renal transplantation. II. Post-transplant disturbances in the CD3 complex expression may be caused by immunosuppression. Arch Immunol Ther Exp (Warsz) 1991;39:297-9.
34. Brassard DL, Grace MJ, Bordens RW. Interferon-α as an immunotherapeutic protein. J Leukocyte Biol 2002;71:565-81.
35. Corssmit EPM, De Metz J, Sauerwein HP, Romjin JA. Biologic responses to IFN-α administration in humans. J Interferon Cytokine Res 2000;20:1039-47.
36. Bank I, Mordechai D, Livneh A. Expansion of γδ T cells in Behçet's disease: role of disease activity and microbial flora in oral ulcers. J Lab Clin Med 2003;141:33-41.
37. Herrmann E. T cells in reactive arthritis. Acta Path Microbiol Immunol Scand 1993;101:177-86.
38. Kabelitz D, Wesch D, Hinz T. γδ T cells: their T cell receptor usage and role in human diseases. Springer Semin Immunopathol 1999; 21:55-75.
39. O'Brien RL, Fu YX, Cornfill R et al. Heat shock protein HSP-60 reactive γδ T cells: a large diversified T lymphocyte subset with highly focused specificity. Proc Natl Acad Sci USA 1992;89: 4348-52.
40. De Libero G. Sentinel function of broadly reactive human γδ T cells. Immunol Today 1997;18:22-6.