Hypothermia in acute liver failure

Metabolic Brain Disease

Volumn 19, Issue 3-4, 2004, Pages 215-221

  Jalan, Rajiv ^a   Rose, Christopher ^b  

^a Institute of Hepatology   (United Kingdom)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Acute liver failure; hepatic encephalopathy; hypothermia; intracranial pressure; liver transplantation

Indexed keywords

AMMONIA; MEMANTINE; METHIONINE SULFOXIMINE;

AMMONIA BLOOD LEVEL; BRAIN BLOOD FLOW; BRAIN EDEMA; CEREBROSPINAL FLUID LEVEL; CONFERENCE PAPER; HUMAN; HYPERAMMONEMIA; INDUCED HYPOTHERMIA; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; LIVER FAILURE; LIVER TRANSPLANTATION; NEUROPATHOLOGY; NONHUMAN;

ANIMALS; BRAIN; BRAIN EDEMA; CLINICAL TRIALS; HEPATIC ENCEPHALOPATHY; HUMANS; HYPERAMMONEMIA; HYPOTHERMIA, INDUCED; INTRACRANIAL HYPERTENSION; LIVER FAILURE, ACUTE; LIVER TRANSPLANTATION; TREATMENT OUTCOME;

EID: 5444266098     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MEBR.0000043971.72170.a2     Document Type: Conference Paper

References (37)

1. Ascher, N.L., Lake, J.R., Emond, J.C., and Roberts, J.P. (1993). Liver transplantation for fulminant hepatic failure. Arch. Surg. 128:677-682.
2. Bélanger, M., Chan, H., Hazell, A.S., and Butterworth, R.F. (2001). Increased lactate dehydrogenase (LDH) expression and activity in cultured astrocytes exposed to ammonia. J. Neurochem. 78(Suppl. 1):25.
3. Bosnian, D.K., Deutz, N.E.P., Maas, M.A.W., van Eijk, H.M.H., Smit, J.J.H., de Hann, J.G., and Chamuleau, R.A.F.M. (1992). Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo cerebral cortex microdialysis. J. Neurochem. 59:591-599.
4. Butterworth, R.F. (1997). Hepatic encephalopathy and brain edema in acute hepatic failure: Does glutamate play a role? Hepatology 25:1032-1035.
5. Chan, H., Hazell, A.S., Desjardins, P., and Butterworth, R.F. (2000). Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes. Neurochem. Int. 37:243-248.
6. Chatauret, N., Rose, C., Therrien, G., and Butterworth, R.F. (2001). Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure. Metab. Brain Dis. 16:95-102.
7. Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D., and Butterworth, R.F. (2003). Effects of hypothermia on brain glucose metabolism in acute liver failure: A 1H/13C-nuclear magnetic resonance study. Gastroenterology 125:815-824.
8. Chodobski, A., Szmydynger-Chodobska, J., Urbanska, A., and Szczepnaska-Sadowska, E. (1986). Intracranial pressure, cerebral blood flow, and cerebrospinal fluid formation during hyperammonemia in the cat. J. Neurosurg. 65:86-91.
9. Clemmensen, J.O., Larsen, F.S., Kondrup, J., Hansen, B.A., and Ott, P. (1999). Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration. Hepatology 29:648-653.
10. Cordoba, J., Crespin, J., Gottstein, J., and Blei, A.T. (1999). Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis. Gastroenterology 116:686-693.
11. Cordoba, J., Gottstein, J., and Blei, A.T. (1996). Glutamine, myoinositol, and organic osmolytes after portacaval anastomosis in the rat: Implications for ammonia-induced brain edema. Hepatology 27:919-923.
12. de Knegt, R.J., Schalm, S.W., van der Rijt, C.C.D., Fekkes, D., Dalm, E., and Hekking-Weyma, I. (1994). Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: An experimental study based on in vivo brain dialysis. J. Hepatol. 20:19-26.
13. Hermenegildo, C., Monfort, P., and Felipo, V. (2000). Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication. Characterization by in vivo microdialysis. Hepatology 31:709-715.
14. Hilgier, W., Zielinska, M., Borkowska, H.D., Gadamski, R., Walski, M., Oja, S.S., Saransaari, P., and Albrecht, J. (1999). Changes in the extracellular profiles of neuroactive amino acids in the rat striatum at the symptomatic stage of hepatic failure. J. Neurosci. Res. 56:76-84.
15. Hoofnagle, J.H., Carithers, R.L., Chapiro, C., and Ascher, N.L. (1995). Fulminant hepatic failure: Summary of a Workshop. Hepatology 21:240-252.
16. Jalan, R. (2003). Intracranial hypertension in acute liver failure: Pathophysiological basis of rational management. Semin. Liver Dis. 271-282.
17. Jalan, R., Olde Damink, S.W.M., Deutz, N.E.P., et al. (1999). Treatment of uncontrolled intracranial hypertension in acute liver failure with moderate hypothermia. Lancet 354:1164-1168.
18. Jalan, R., Olde Damink, S.W.M., Deutz, N.E.P., et al. (2001). Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia. Hepatology 34:50-54.
19. Jalan, R., Olde Damink, S.W.M., Deutz, N.E.P., et al. (2003). Moderate hypothermia prevents cerebral hyperemia and increase in intracranial pressure in patients undergoing liver transplantation for acute liver failure. Transplantation 75:2034-2039.
20. Knecht, K., Michalak, A., Rose, C., Rothstein, J.D., and Butterworth, R.F. (1997). Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neurosci. Lett. 229:201-203.
21. Lai, J.C.K., and Cooper, A.J.L. (1986). Brain α-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution and effects of inhibitors. J. Neurochem. 47:1376-1386.
22. Makin, A.J., Wendon, J., and Williams, R. (1995). A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993). Gastroenterology 109:1907-1916.
23. Mans, A.M., De Joseph, M.R., and Hawkins, R.A. (1994). Metabolic abnormalities and grade of encephalopathy in acute hepatic failure. J. Neurochem. 63:1829-1838.
24. Michalak, A., Rose, C., Butterworth, J., and Butterworth, R.F. (1996). Neuroactive amino acides and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology 24:908-914.
25. Norenberg, M.D., and Bender, A.S. (1994). Astrocyte swelling in liver failure: Role of glutamine and benzodiazepines. Acta Neurochir. Suppl. (Wien). 60:24-27.
26. O'Grady, J.G., Alexander, G.J.M., Hayllar, K.M., and Williams, R. (1989). Early indicators of prognosis in fulminant hepatic failure. Gastroenterology 97:439-445.
27. Peignoux, M., Bernuau, J., and Benhamou, J.P. (1982). Total hepatectomy and vascular exclusion in the rat. A comparison, with special reference to the influence of body temperature. Clin. Sci. 62:273-277.
28. Rao, K.V., and Norenberg, M.D. (2001). Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia. Metab. Brain Dis. 16:67-78.
29. Rose, C. (2002). Increased extracellular brain glutamate in acute liver failure: Decreased uptake or increased released? Metab. Brain Dis. 17:251-261.
30. Rose, C., Michalak, A., Rambaldi, A., Chatauret, N., Pannunzio, M., and Butterworth, R.F. (2000). Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology 31:872-877.
31. Schenker, S., and Warren, K.S. (1962). Effect of temperature variation on toxicity and metabolism of ammonia in mice. J. Lab. Clin. Med. 60:291-301.
32. Swain, M., Butterworth, R.F., and Blei, A.T. (1992). Ammonia and related amino acids in the pathogenesis of brain edema in acute liver failure in rats. Hepatology 15:449-453.
33. Takahashi, H., Koehler, R.C., Brusilow, S.W., and Traysman, R.J. (1991). Inhibition of brain glutamine accumulation prevents cerebral edemain hyperammonemic rats. Am. J. Physiol. 261:H825-H829.
34. Tofteng, F., Jorgensen, L., Hansen, B.A., et al. (2002). Cerebral microdialysis in patients with fulminant hepatic failure. Hepatology 36:1333-1340.
35. Traber, P., Canto, M., Ganger, D., and Blei, A.T. (1989). Effect of body temperature on brain edema and encephalopathy in the rat after hepatic devascularization. Gastroenterology 96:885-891.
36. Trey, C., and Davidson, C.S. (1970). The management of fulminant hepatic failure. In (H. Popper and F. Schaffner, eds.), Progress in Liver Disease, Grune and Stratton, New York, Vol. III, pp. 282-298.
37. Vogels, B.A.P., Maas, M.A.W., Daalhuisen, J., Quack, G., and Chamuleau, R.A.F.M. (1997). Memantine, a non-competitive NMDA-receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats. Hepatology 25:820-827.