Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis

Journal of General Virology

Volumn 85, Issue 10, 2004, Pages 3017-3026

  Bartholdy, Christina ^a,b   Olszewska, Wieslawa ^a   Stryhn, Anette ^b,c   Thomsen, Allan Randrup ^b   Openshaw, Peter J M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c T Cellic A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CD8 ANTIGEN; DNA VACCINE; EPITOPE; PROTEIN M2; RESPIRATORY SYNCYTIAL VIRUS VACCINE; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; BODY WEIGHT DISORDER; CELL INFILTRATION; CONTROLLED STUDY; COVALENT BOND; DISEASE SEVERITY; FEMALE; GENE CONSTRUCT; GENE GUN; IMMUNOPATHOLOGY; LUNG DISEASE; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; MOUSE STRAIN; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; T LYMPHOCYTE; VACCINIA VIRUS; VIRUS TRANSCRIPTION; ANIMAL; BAGG ALBINO MOUSE; BIOLISTIC TRANSFORMATION; CD8+ T LYMPHOCYTE; CPG ISLAND; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; VACCINATION; VIRUS INFECTION; VIRUS PNEUMONIA;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS; VACCINIA VIRUS;

ANIMALS; BIOLISTICS; CD8-POSITIVE T-LYMPHOCYTES; CPG ISLANDS; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; PNEUMONIA, VIRAL; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS VACCINES; VACCINATION; VACCINES, DNA; VIRAL PROTEINS;

EID: 5444257335     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.80098-0     Document Type: Article

References (31)

1. + T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses. J Virol 62 2102-2106.
2. Alwan, W. H. & Openshaw, P. J. M. (1993). Distinct patterns of T- and B-cell immunity to respiratory syncytial virus induced by individual viral proteins. Vaccine 11, 431-437.
3. + T cells in gene gun DNA-vaccinated mice. Eur J Immunol 33, 1941-1948.
4. Bembridge, G. P., Rodriguez, N., Garcia-Beato, R., Nicolson, C., Melero, J. A. & Taylor, G. (2000). Respiratory syncytial virus infection of gene gun vaccinated mice induces Th2-driven pulmonary eosinophilia even in the absence of sensitisation to the fusion (F) or attachment (G) protein. Vaccine 19, 1038-1046.
5. + T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol 2, 1067-1076.
6. Chin, J., Magoffin, R. L., Shearer, L. A., Schieble, J. H. & Lennette, E. H. (1969). Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol 89, 449-463.
7. Christensen, J. E., Christensen, J. P., Kristensen, N. N., Hansen, N. J. V., Stryhn, A. & Thomsen, A. R. (2002). Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells. Int Immunol 14, 701-711.
8. Feltquate, D. M., Heaney, S., Webster, R. G. & Robinson, H. L. (1997). Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 158 2278-2284.
9. Hsu, S.-C., Chargelegue, D. & Steward, M. W. (1998a). Reduction of respiratory syncytial virus titer in the lungs of mice after intranasal immunization with a chimeric peptide consisting of a single CTL epitope linked to a fusion peptide. Virology 240, 376-381.
10. Hsu, S.-C., Obeid, O. E., Collins, M., Iqbal, M., Chargelegue, D. & Steward, M. W. (1998b). Protective cytotoxic T lymphocyte responses against paramyxoviruses induced by epitope-based DNA vaccines: involvement of IFN-γ. Int Immunol 10, 1441-1447.
11. + T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur J Immunol 27, 3341-3349.
12. Iqbal, M., Lin, W., Jabbal-Gill, I., Davis, S. S., Steward, M. W. & Ilium, L. (2003). Nasal delivery of chitosan-DNA plasmid expressing epitopes of respiratory syncytial virus (RSV) induces protective CTL responses in BALB/c mice. Vaccine 21, 1478-1485.
13. Isaacs, D. (1991). Viral subunit vaccines. Lancet 337, 1223-1224.
14. Kapikian, A. Z., Mitchell, R. H., Chanock, R. M., Shvedoff, R. A. & Stewart, C. E. (1969). An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol 89, 405-421.
15. + cytotoxic T cells. J Virol 67, 4086-4092.
16. Kulkarni, A. B., Collins, P. L., Bacik, I., Yewdell, J. W., Bennink, J. R., Crowe, J. E., Jr & Murphy, B. R. (1995). Cytotoxic T cells specific for a single peptide on the M2 protein of respiratory syncytial virus are the sole mediators of resistance induced by immunization with M2 encoded by a recombinant vaccinia virus. J Virol 69, 1261-1264.
17. Li, X., Sambhara, S., Li, C. X. & 7 other authors (1998). Protection against respiratory syncytial virus infection by DNA immunization. J Exp Med 188, 681-688.
18. Masopust, D., Vezys, V., Marzo, A. L. & Lefrancois, L. (2001). Preferential localization of effector memory cells in nonlymphoid tissue. Science 291, 2413-2417.
19. Murphy, B. R., Hall, S. L., Kulkarni, A. B., Crowe, J. E., Jr, Collins, P. L., Connors, M., Karron, R. A. & Chanock, R. M. (1994). An update on approaches to the development of respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) vaccines. Virus Res 32, 13-36.
20. d-restricted cytotoxic T lymphocytes from mice primed by infection. J Virol 64, 1683-1689.
21. Openshaw, P. J. M., Clarke, S. L. & Record, F. M. (1992). Pulmonary eosinophilic response to respiratory syncytial virus infection in mice sensitized to the major surface glycoprotein G. Int Immunol 4, 493-500.
22. Ostler, T., Pircher, H. & Ehl, S. (2003). " Bystander" recruitment of systemic memory T cells delays the immune response to respiratory virus infection. Eur J Immunol 33, 1839-1848.
23. Pertmer, T. M., Roberts, T. R. & Haynes, J. R. (1996). Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA"delivery. J Virol 70, 6119-6125.
24. + T cell responses. J Immunol 166, 1106-1113.
25. + T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med 186, 421-432.
26. Stein, R. T., Sherrill, D., Morgan, W. J., Holberg, C. J., Halonen, M., Taussig, L. M., Wright, A. L. & Martinez, F. D. (1999 . Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354, 541-545.
27. Stott, E. J., Taylor, G., Ball, L. A., Anderson, K., Young, K. K.-Y., King, A. M. Q. & Wertz, G. W. (1987). Immune and histopathological responses in animals vaccinated with recombinant vaccinia viruses that express individual genes of human respiratory syncytial virus. J Virol 61, 3855-3861.
28. Taylor, G., Stott E. J., Hughes, M. & Collins, A. P. (1984). Respiratory syncytial virus infection in mice. Infect Immun 43, 649-655.
29. Tripp, R. A., Moore, D., Jones, L., Sullender, W., Winter, J. & Anderson, L. J. (1999). Respiratory syncytial virus G and /or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol 73, 7099-7107.
30. Welsh, R. M. & Selin, L. K. (2002). No one is naive: the significance of heterologous T-cell immunity. Nat Rev Immunol 2, 417-426.
31. Zhou, X., Zheng, L., Liu, L., Xiang, L. & Yuan, Z. (2003). T helper 2 immunity to hepatitis B surface antigen primed by gene-gun-mediated DNA vaccination can be shifted towards T helper 1 immunity by codelivery of CpG motif-containing oligodeoxynucleotides. Scand J Immunol 58, 350-357.