Formulation development and human in vitro-in vivo correlation for a novel, monolithic controlled-release matrix system of high load and highly water-soluble drug niacin

Drug Development and Industrial Pharmacy

Volumn 30, Issue 8, 2004, Pages 797-807

  Turner, S ^a   Federici, C ^a   Hite, M ^a   Fassihi, R ^b  

^a Product Development   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

Controlled release; IVIVC; Matrix system; Niacin delivery system; Polymeric carriers; Swelling dynamics

Indexed keywords

BICARBONATE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; NICOTINIC ACID; WATER;

ADULT; ARTICLE; CALCULATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; GEL; HUMAN; KINETICS; MACROMOLECULE; MALE; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SUSTAINED RELEASE FORMULATION; VISCOSITY;

ADMINISTRATION, ORAL; ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG EVALUATION, PRECLINICAL; HUMANS; HYDROPHOBICITY; INTESTINAL ABSORPTION; INTESTINE, SMALL; KINETICS; MALE; METHYLCELLULOSE; NIACIN; PERMEABILITY; POLYETHYLENE GLYCOLS; SODIUM BICARBONATE; SOLUBILITY; STOMACH; TABLETS; TECHNOLOGY, PHARMACEUTICAL; THERAPEUTIC EQUIVALENCY; WATER;

EID: 5444252837     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-200026747     Document Type: Article

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