메뉴 건너뛰기




Volumn 19, Issue 10, 2004, Pages 2576-2583

4-Heptanone is a metabolite of the plasticizer di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients

Author keywords

4 heptanon; DEHP; Diabetes mellitus; Haemodialysis; In vivo metabolism

Indexed keywords

2 ETHYLHEXANOIC ACID; 4 HEPTANONE; DRUG METABOLITE; GLUCOSE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PLASTICIZER; UNCLASSIFIED DRUG;

EID: 5444238373     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfh425     Document Type: Article
Times cited : (41)

References (24)
  • 1
    • 0033020938 scopus 로고    scopus 로고
    • Identification of plasticizers in medical products by a combined direct thermodesorption-cooled injection system and gas chromatography-mass spectrometry
    • Wahl HG, Hoffmann A, Haring HU, Liebich HM. Identification of plasticizers in medical products by a combined direct thermodesorption-cooled injection system and gas chromatography-mass spectrometry. J Chromatogr A 1999; 847: 1-7
    • (1999) J. Chromatogr. A , vol.847 , pp. 1-7
    • Wahl, H.G.1    Hoffmann, A.2    Haring, H.U.3    Liebich, H.M.4
  • 2
    • 0014954187 scopus 로고
    • Contamination of blood stored in plastic packs
    • Jaeger RJ, Rubin RJ. Contamination of blood stored in plastic packs. Lancet 1970; 2: 151
    • (1970) Lancet , vol.2 , pp. 151
    • Jaeger, R.J.1    Rubin, R.J.2
  • 3
    • 0023149910 scopus 로고
    • Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis
    • Nassberger L, Arbin A, Ostelius J. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. Nephron 1987; 45: 286-290
    • (1987) Nephron , vol.45 , pp. 286-290
    • Nassberger, L.1    Arbin, A.2    Ostelius, J.3
  • 5
    • 0033001883 scopus 로고    scopus 로고
    • A cancer risk assessment of di(2-ethylhexyl)phthalate: Application of the new U.S. EPA Risk Assessment Guidelines
    • Doull J, Cattley R. Elcombe C et al. A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines. Regul Toxicol Pharmacol 1999; 29: 327-357
    • (1999) Regul. Toxicol. Pharmacol. , vol.29 , pp. 327-357
    • Doull, J.1    Cattley, R.2    Elcombe, C.3
  • 6
    • 0035153953 scopus 로고    scopus 로고
    • Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: A critical review
    • Tickner JA, Schettler T, Guidotti T, McCally M, Rossi M. Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review. Am J Indust Med 2001; 39: 100-111
    • (2001) Am. J. Indust. Med. , vol.39 , pp. 100-111
    • Tickner, J.A.1    Schettler, T.2    Guidotti, T.3    McCally, M.4    Rossi, M.5
  • 7
    • 0037687572 scopus 로고    scopus 로고
    • Polycaprolactone-poly(ethylene glycol) multiblock copolymers as potential substitutes for di(ethylhexyl) phthalate in flexible poly(vinyl chloride) formulations
    • Ferruti P, Mancin I, Ranucci E, De Felice C, Latini G, Laus M. Polycaprolactone-poly(ethylene glycol) multiblock copolymers as potential substitutes for di(ethylhexyl) phthalate in flexible poly(vinyl chloride) formulations. Biomacromolecules 2003; 4: 181-188
    • (2003) Biomacromolecules , vol.4 , pp. 181-188
    • Ferruti, P.1    Mancin, I.2    Ranucci, E.3    De Felice, C.4    Latini, G.5    Laus, M.6
  • 8
    • 0034066245 scopus 로고    scopus 로고
    • Influence of plasticizer-free CAPD bags and tubings on serum, urine, and dialysate levels of phthalic acid esters in CAPD patients
    • Mettang T, Pauli-Magnus C, Alscher DM et al. Influence of plasticizer-free CAPD bags and tubings on serum, urine, and dialysate levels of phthalic acid esters in CAPD patients. Perit Dial Int 2000; 20: 80-84
    • (2000) Perit. Dial. Int. , vol.20 , pp. 80-84
    • Mettang, T.1    Pauli-Magnus, C.2    Alscher, D.M.3
  • 9
    • 0021889599 scopus 로고
    • Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate
    • Mitchell AM, Lhuguenot JC, Bridges JW, Elcombe CR. Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol 1985; 80: 23-32
    • (1985) Toxicol. Appl. Pharmacol. , vol.80 , pp. 23-32
    • Mitchell, A.M.1    Lhuguenot, J.C.2    Bridges, J.W.3    Elcombe, C.R.4
  • 10
    • 0032585881 scopus 로고    scopus 로고
    • Trans-activation of PPAR alpha and PPAR gamma by structurally diverse environmental chemicals
    • Maloney EK, Waxman DJ. Trans-activation of PPAR alpha and PPAR gamma by structurally diverse environmental chemicals. Toxicol Appl Pharmacol 1999; 161: 209-218
    • (1999) Toxicol. Appl. Pharmacol. , vol.161 , pp. 209-218
    • Maloney, E.K.1    Waxman, D.J.2
  • 11
    • 0031830436 scopus 로고    scopus 로고
    • Nephrotoxic effects of di-(2-ethylhexyl)-phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells
    • Rothenbacher KP, Kimmel R, Hildenbrand S, Schmahl FW, Dartsch PC. Nephrotoxic effects of di-(2-ethylhexyl)-phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells. Hum Exp Toxicol 1998; 17: 336-342
    • (1998) Hum. Exp. Toxicol. , vol.17 , pp. 336-342
    • Rothenbacher, K.P.1    Kimmel, R.2    Hildenbrand, S.3    Schmahl, F.W.4    Dartsch, P.C.5
  • 12
    • 0016703454 scopus 로고
    • The metabolism of 2-ethylhexanol in rats
    • Albro PW. The metabolism of 2-ethylhexanol in rats. Xenobiotica 1975; 5: 625-636
    • (1975) Xenobiotica , vol.5 , pp. 625-636
    • Albro, P.W.1
  • 13
    • 0027245031 scopus 로고
    • Determination of four metabolites of the plasticizer di(2-ethylhexyl)phthalate in human urine samples
    • Dirven HA, van den Broek PH, Jongeneelen FJ. Determination of four metabolites of the plasticizer di(2-ethylhexyl)phthalate in human urine samples. Int Arch Occup Environ Health 1993; 64: 555-560
    • (1993) Int. Arch. Occup. Environ. Health , vol.64 , pp. 555-560
    • Dirven, H.A.1    van den Broek, P.H.2    Jongeneelen, F.J.3
  • 14
    • 0016864485 scopus 로고
    • Gas chromatographic-mass spectrometric study of volatile organic metabolites in urines of patients with diabetes mellitus
    • Liebich HM, Al Babbili O. Gas chromatographic-mass spectrometric study of volatile organic metabolites in urines of patients with diabetes mellitus. J Chromatogr 1975; 112: 539-550
    • (1975) J. Chromatogr. , vol.112 , pp. 539-550
    • Liebich, H.M.1    Al Babbili, O.2
  • 15
    • 0015614913 scopus 로고
    • Profile of volatile metabolites in urine by gas chromatography-mass spectrometry
    • Zlatkis A, Bertsch W, Lichtenstein HA et al. Profile of volatile metabolites in urine by gas chromatography-mass spectrometry. Anal Chem 1973; 45: 763-767
    • (1973) Anal. Chem. , vol.45 , pp. 763-767
    • Zlatkis, A.1    Bertsch, W.2    Lichtenstein, H.A.3
  • 16
    • 0017622601 scopus 로고
    • Volatile substances in blood serum: Profile analysis and quantitative determination
    • Liebich HM, Woll J. Volatile substances in blood serum: profile analysis and quantitative determination. J Chromatogr 1977; 142: 505-516
    • (1977) J. Chromatogr. , vol.142 , pp. 505-516
    • Liebich, H.M.1    Woll, J.2
  • 17
    • 0343841665 scopus 로고    scopus 로고
    • Identification of in vivo DEHP metabolites in breath, plasma and urine of dialysis patients
    • [abstract]
    • Wahl HG, Luft D, Risler T, Liebich HM. Identification of in vivo DEHP metabolites in breath, plasma and urine of dialysis patients. Nephrol Dial Transplant 1997; 12: A6 [abstract]
    • (1997) Nephrol. Dial. Transplant. , vol.12
    • Wahl, H.G.1    Luft, D.2    Risler, T.3    Liebich, H.M.4
  • 18
    • 5444252016 scopus 로고    scopus 로고
    • 4-Heptanone is a major metabolite of the plasticiser di(2-ethylhexyl) phthalate (DEHP) in humans
    • [abstract]
    • Wahl HG, Risler T, Luft D, Dartsch PC, Liebich HM. 4-Heptanone is a major metabolite of the plasticiser di(2-ethylhexyl) phthalate (DEHP) in humans. Nephrol Dial Transplant 2002; 17 [Suppl 1]: 292 [abstract]
    • (2002) Nephrol. Dial. Transplant. , vol.17 , Issue.SUPPL. 1 , pp. 292
    • Wahl, H.G.1    Risler, T.2    Luft, D.3    Dartsch, P.C.4    Liebich, H.M.5
  • 19
    • 0032981755 scopus 로고    scopus 로고
    • Analysis of volatile organic compounds in human urine by headspace gas chromatography-mass spectrometry with a multipurpose sampler
    • Wahl HG, Hoffmann A, Luft D, Liebich HM. Analysis of volatile organic compounds in human urine by headspace gas chromatography-mass spectrometry with a multipurpose sampler. J Chromatogr A 1999; 847: 117-125
    • (1999) J. Chromatogr. A , vol.847 , pp. 117-125
    • Wahl, H.G.1    Hoffmann, A.2    Luft, D.3    Liebich, H.M.4
  • 20
    • 0035879887 scopus 로고    scopus 로고
    • Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry
    • Wahl HG, Hong Q, Stube D, Maier ME, Haring HU, Liebich HM. Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry. J Chromatogr B 2001; 758: 213-219
    • (2001) J. Chromatogr. B , vol.758 , pp. 213-219
    • Wahl, H.G.1    Hong, Q.2    Stube, D.3    Maier, M.E.4    Haring, H.U.5    Liebich, H.M.6
  • 21
    • 0030453119 scopus 로고    scopus 로고
    • Uraemic pruritus and exposure to di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients
    • Mettang T, Thomas S, Kiefer T et al. Uraemic pruritus and exposure to di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients. Nephrol Dial Transplant 1996; 11: 2439-2443
    • (1996) Nephrol. Dial. Transplant. , vol.11 , pp. 2439-2443
    • Mettang, T.1    Thomas, S.2    Kiefer, T.3
  • 22
    • 0035085846 scopus 로고    scopus 로고
    • Urine 4-heptanone: A beta-oxidation product of 2-ethylhexanoic acid from plasticisers
    • Walker V, Mills GA. Urine 4-heptanone: a beta-oxidation product of 2-ethylhexanoic acid from plasticisers. Clin Chim Acta 2001; 306: 51-61
    • (2001) Clin. Chim. Acta , vol.306 , pp. 51-61
    • Walker, V.1    Mills, G.A.2
  • 23
    • 0021823729 scopus 로고
    • Excretion and metabolism of di(2-ethylhexyl)phthalate in man
    • Schmid P, Schlatter C. Excretion and metabolism of di(2-ethylhexyl)phthalate in man. Xenobiotica 1985; 15: 251-256
    • (1985) Xenobiotica , vol.15 , pp. 251-256
    • Schmid, P.1    Schlatter, C.2
  • 24
    • 0035325333 scopus 로고    scopus 로고
    • Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)?
    • Melnick RL. Is peroxisome proliferation an obligatory precursor step in the carcinogenicity of di(2-ethylhexyl)phthalate (DEHP)? Environ Health Perspect 2001; 109: 437-442
    • (2001) Environ. Health Perspect. , vol.109 , pp. 437-442
    • Melnick, R.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.