An open-label study of levetiracetam for the treatment of social anxiety disorder

Journal of Clinical Psychiatry

Volumn 65, Issue 9, 2004, Pages 1219-1222

  Simon, Naomi M ^a   Worthington, John J ^a   Doyle, Alicia C ^a   Hoge, Elizabeth A ^a   Kinrys, Gustavo ^b   Fischmann, Diana ^a   Link, Nathaniel ^a   Pollack, Mark H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; DRUG DERIVATIVE; ETIRACETAM; PIRACETAM;

ADULT; AMBULATORY CARE; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG ADMINISTRATION; FEMALE; HOSPITALIZATION; HUMAN; MALE; PHOBIA; PILOT STUDY; PROSPECTIVE STUDY; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; TREATMENT OUTCOME;

ADULT; AMBULATORY CARE; ANTICONVULSANTS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; PHOBIC DISORDERS; PILOT PROJECTS; PIRACETAM; PROSPECTIVE STUDIES; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 5444235771     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v65n0909     Document Type: Article

References (32)

1. Kessler RC, McGonagle KA, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: results from the National Comorbidity Survey. Arch Gen Psychiatry 1994;51: 8-19 (Pubitemid 24028993)
2. Weiller E, Bisserbe JC, Boyer P, et al. Social phobia in general health care: an unrecognised undertreated disabling disorder. Br J Psychiatry 1996;168:169-174 (Pubitemid 126425216)
3. Magee WJ, Eaton WW, Wittchen HU, et al. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. Arch Gen Psychiatry 1996;53:159-168 (Pubitemid 26049391)
4. Schneier FR, Chin SJ, Hollander E, et al. Fluoxetine in social phobia. J Clin Psychopharmacol 1992;12:62-64
5. Davidson JR, Potts N, Richichi E, et al. Treatment of social phobia with clonazepam and placebo. J Clin Psychopharmacol 1993;13:423-428 (Pubitemid 24026104)
6. Liebowitz MR, Stein MB, Tancer M, et al. A randomized, double-blind, fixed-dose comparison of paroxetine and placebo in the treatment of generalized social anxiety disorder. J Clin Psychiatry 2002;63:66-74 (Pubitemid 34113490)
7. Stein MB, Liebowitz MR, Lydiard RB, et al. Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. JAMA 1998;280:708-713 (Pubitemid 28405295)
8. Heimberg RG, Liebowitz MR, Hope DA, et al. Cognitive behavioral group therapy vs phenelzine therapy for social phobia: 12-week outcome. Arch Gen Psychiatry 1998;55:1133-1141 (Pubitemid 28558287)
9. Shaywitz JE, Liebowitz MR. Antiepileptic treatment of anxiety disorders. Primary Psychiatry 2003;10:51-56 (Pubitemid 38435985)
10. Pande AC, Davidson JR, Jefferson JW, et al. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 1999;19:341-348 (Pubitemid 29344848)
11. Feltner DE, Davidson JRT, Pollack MH, et al. A placebo-controlled, double-blind study of pregabalin treatment of social anxiety disorder: outcome and predictors or response [poster]. Presented at the 39th annual meeting of the American College of Neuropsychopharmacology; Dec. 10-14, 2000; San Juan, Puerto Rico
12. Kinrys G, Pollack MH, Simon NM, et al. Valproic acid for the treatment of social anxiety disorder. Int Clin Psychopharmacol 2003;18:169-172 (Pubitemid 36571062)
13. VanAmeringen M, Mancini C, Pipe B. An open trial of topiramate in the treatment of generalized social phobia. Presented at the 52nd annual meeting of the Canadian Psychiatric Association; Oct 31-Nov 3, 2002; Alberta, Canada
14. Niespodziany I, Klitgaard H, Margineanu DG. Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neurosci Lett 2001;306:5-8
15. Noyer M, Gillard M, Matagne A, et al. The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur J Pharmacol 1995;286:137-146
16. Rigo JM, Hans G, Nguyen L, et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br J Pharmacol 2002;136:659-672 (Pubitemid 34785708)
17. Lamberty Y, Gower AJ, Klitgaard H. The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice. Eur J Pharmacol 2002;439:101-106 (Pubitemid 34286612)
18. First MB, Spitzer RL, Gibbon M, et al. Structured Clinical Interview for DSM-IV Axis I Disorders, Patient Version. (SCID-1/P version 2.0) New York: New York State Psychiatric Institute, Biometrics Research, 1994
19. Heimberg RG, Horner KJ, Juster HR, et al. Psychometric properties of the Liebowitz Social Anxiety Scale. Psychol Med 1999;29:199-212 (Pubitemid 29034537)
20. Guy W. ECDEU Assessment Manual for Psychopharmacology. US Dept Health, Education, and Welfare publication (ADM) 76-338. Rockville, Md: National Institute of Mental Health; 1976:218-222
21. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62
22. Hamilton M. The assessment of anxiety states by rating. Br J Med Psychol 1959;32:50-55
23. Rapaport MH, Davidson JR. The efficacy of new pharmacological treatments for panic disorder: evaluating the trials. Psychopharmacol Bull 1998;34:167-168 (Pubitemid 28292703)
24. Sheehan DV, Harnett-Sheehan K, Raj BA. The measurement of disability. Int Clin Psychopharmacol 1996;11(suppl 3):89-95 (Pubitemid 26373761)
25. Ballenger JC, Davidson JR, Lecrubier Y, et al. Consensus statement on social anxiety disorder from the International Consensus Group on Depression and Anxiety. J Clin Psychiatry 1998;59(suppl 17):54-60 (Pubitemid 28487516)
26. Gould RA, Buckminster S, Pollack MH, et al. Cognitive-behavioral and pharmacological treatment for social phobia: a meta-analysis. Clin Psychol 1997;4:291-306 (Pubitemid 127534852)
27. Lenze EJ, Pollock BG, Shear MK, et al. Treatment considerations for anxiety in the elderly. CNS Spectr 2003;8(12 suppl 3):6-13 (Pubitemid 38405518)
28. Cramer JA, Leppik IE, Rue KD, et al. Tolerability of levetiracetam in elderly patients with CNS disorders. Epilepsy Res 2003;56:135-145 (Pubitemid 37474114)
29. Wang PW, Ketter TA, Becker OV, et al. New anticonvulsant medication uses in bipolar disorder. CNS Spectr 2003;8:930-932, 941-947 (Pubitemid 38405529)
30. Van Ameringen MA, Lane RM, Walker JR, et al. Sertraline treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study. Am J Psychiatry 2001;158:275-281 (Pubitemid 32116525)
31. Stein DJ, Versiani M, Hair T, et al. Efficacy of paroxetine for relapse prevention in social anxiety disorder: a 24-week study. Arch Gen Psychiatry 2002;59:1111-1118 (Pubitemid 35424021)
32. Kinrys G, Worthington JW, Pardo T, et al. Levetiracetam as adjunctive therapy for refractory anxiety disorders [poster]. Presented at the XXIVth Congress of Collegium Internationale Neuro-Psychopharmacologicum, Paris, France, June 20-24, 2004