Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17α-Ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors

Toxicological Sciences

Volumn 106, Issue 1, 2008, Pages 113-123

  Lange, Anke ^a   Katsu, Yoshinao ^b   Ichikawa, Rie ^b   Paull, Gregory C ^a   Chidgey, Laura L ^a   Coe, Tobias S ^a   Iguchi, Taisen ^b   Tyler, Charles R ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

Author keywords

17 ethinylestradiol; Aromatases; Developmental gene expression dynamics; Endocrine disruption; Estrogen receptors; Feminization

Indexed keywords

AROMATASE; CYTOCHROME; CYTOCHROME P450 19A1A; CYTOCHROME P450 19A1B; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR 1; ESTROGEN RECEPTOR 2B; ETHINYLESTRADIOL; RNA; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENVIRONMENTAL EXPOSURE; FEMALE; FEMINIZATION; FISH; GENE EXPRESSION; GONAD DEVELOPMENT; MALE; MOLECULAR CLONING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; RNA EXTRACTION; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT;

ANIMALS; AROMATASE; CYPRINIDAE; ENDOCRINE DISRUPTORS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHINYL ESTRADIOL; FEMALE; FEMINIZATION; FISH PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GONADS; ISOENZYMES; MALE; SEXUAL DEVELOPMENT; TIME FACTORS; VITELLOGENESIS; VITELLOGENINS; WATER POLLUTANTS, CHEMICAL;

RUTILUS RUTILUS;

EID: 54349123857     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn151     Document Type: Article

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