The use of a GnRH vaccine to suppress mare ovarian activity in a large group of mares under field conditions

Wildlife Research

Volumn 35, Issue 6, 2008, Pages 548-554

  Botha, A E ^a   Schulman, M L ^a   Bertschinger, H J ^a   Guthrie, A J ^a   Annandale, C H ^a   Hughes, S B ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

AGE STRUCTURE; ELEPHANT; EXPERIMENTAL STUDY; FERTILITY; FIELDWORK; HORMONE; PREGNANCY; SERUM; UNGULATE; VACCINATION; VACCINE; WILDLIFE MANAGEMENT;

ANIMALIA; EQUUS SUBG. HIPPOTIGRIS; LOXODONTA;

EID: 54349114096     PISSN: 10353712     EISSN: None     Source Type: Journal    
DOI: 10.1071/WR07136     Document Type: Conference Paper

References (42)

1. Asa, C. S., Goldfoot, D. A., Garcia, M. C., and Ginther, O. J. (1980). Sexual behaviour in ovariectomized and seasonally anovulatory pony mares (Equus caballus). Hormones and Behavior 14, 46-54. doi: 10.1016/0018-506X(80)90014-8
2. Becker, S. E., Enright, W. J., and Katz, L. S. (1999). Active immunization against gonadotropin-releasing hormone in female white-tailed deer. Zoo Biology 18, 385-396. doi: 10.1002/(SICI)1098-2361(1999)18: 5〈385::AID-ZOO3〉3.0.CO;2-3
3. Bertschinger, H. J., DeNys, H., Turkstra, J. A., and Human, A. (2004). Control of aggressive behaviour in African elephants (Loxodonta africana) with a GnRH vaccine. Advances in Ethology, Supplements to Ethology 38, 23.
4. Brown, J. L., Walker, S. L., and Moeller, T. (2004). Comparative endocrinology of cycling and non-cycling Asian (Elephas maximus) and African (Loxodonta africana) elephants. General and Comparative Endocrinology 136, 360-370. doi: 10.1016/j.ygcen.2004.01.013
5. Burger, D., Janett, F., Vidament, M., Stump, R., Fortier, G., Imboden, I., and Thun, R. (2006). Immunocastration against GnRH in adult stallions: effects on semen characteristics, behaviour and shedding of equine arteritis virus. Animal Reproduction Science 94, 107-111. doi: 10.1016/j.anireprosci.2006.03.098
6. Chumkam, S., and Ravungsook, S. (2003). Effect of immunization against gonadotropin releasing hormone on growth rate and carcass quality in boar. In 'Proceedings of the 41st Kasetsart University Annual Conference. Subject Animals and Veterinary Medicine'. pp. 427-433. (Kasetsart University: Bangkok, Thailand.)
7. Curtis, P. D., Pooler, R. L., Richmond, M. E., Miller, L. A., Marrfeld, G. F., and Quimby, F. W. (2001). Comparative effects of GnRH and porcine zona pellucida (PZP) immunocontraceptive vaccines for controlling reproduction in white-tailed deer (Odocoileus virginianus). Reproduction 60(Suppl.), 131-141.
8. D'Occhio, M. J. (1993). Immunological suppression of reproductive functions in male and female mammals. Animal Reproduction Science 33, 345-372. doi: 10.1016/0378-4320(93)90123-9
9. Dalin, A. M., Andresen, Ø., and Malmgren, L. (2002). Immunization against GnRH in mature mares: antibody titres, ovarian function, hormonal levels and oestrus behaviour. Journal of Veterinary Medicine 49, 125-131. doi: 10.1046/j.1439-0442.2002.00427.x
10. Delsink, A., Bertschinger, H. J., Kirkpatrick, J. F., DeNys, H., Grobler, D., van Altena, J. J., and Turkstra, J. (2004). Contraception of elephant cows in two private conservancies using porcine zona pellucida vaccine, and control of aggressive behaviour in elephant bulls with a GnRH vaccine. In 'Proceedings of an Expert Consultation on the Control of Wild Elephant Populations'. pp. 69-72. (Utrecht University: The Netherlands.)
11. Delsink, A. K., van Altena, J. J., Grobler, D., Bertschinger, H., Kirkpatrick, J. F., and Slotow, R. (2006). Regulation of a small, discrete African elephant population through immunocontraception in the Makalali Conservancy, Limpopo, South Africa. South African Journal of Science 102, 403-405.
12. Dowsett, K. F., Knott, L. M., Tshewang, U., Jackson, A. E., Bodero, D. A., and Trigg, T. E. (1996). Suppression of testicular function using two dose rates of reversible water soluble gonadotropin-releasing hormone (GnRH) vaccine in colts. Australian Veterinary Journal 74, 228-235.
13. Dunshea, F. R., Colantoni, C., Howard, K., Mc Cauley, I., Jackson, P. et al. (2001). Vaccination of boars with GnRH vaccine (Improvac) eliminates boar taint and increases growth performance. Journal of Animal Science 79, 2525-2535.
14. Elhay, M., Newbold, A., Britton, A., Turley, P., Dowsett, K., and Walker, J. (2007). Suppression of behavioural and physiological oestrus in the mare by vaccination against GnRH. Australian Veterinary Journal 85, 39-45. doi: 10.1111/j.1751-0813.2006.00092.x
15. Ferro, V. A., Khan, M. A. H., McAdam, D., Colston, A., Aughey, E., Mullen, A. B., Waterston, M. M., and Harvey, M. J. A. (2004). Efficacy of an antifertility vaccine based on mammalian gonadotrophic releasing hormone (GnRH-I) - a histological comparison in male animals. Veterinary Immunology and Immunopathology 101, 73-86. doi: 10.1016/j.vetimm.2004.03.011
16. Garza, F., Thompson, D. L., French, D. D., Wiest, J. J., St George, R. L. et al. (1986). Active immunization of intact mares against gonadotropin-releasing hormone: differential effects on secretion of luteinizing hormone and follicle-stimulating hormone. Biology of Reproduction 35, 347-352. doi: 10.1095/biolreprod35.2.347
17. Ginther, O. J. (1979). Sexual behaviour. In 'Reproductive Biology of the Mare. Basic and Applied Aspects'. pp. 59-82. (Equiservices: Wisconsin.)
18. Hayes, K. E. N., Pierson, R. A., Scraba, S. T., and Ginther, O. J. (1985). Effects of oestrous cycle and season on ultrasonic uterine anatomy in mares. Theriogenology 24, 465-477. doi: 10.1016/0093-691X(85) 90053-6
19. Hooper, R. N., Taylor, T. S., Varner, D. D., and Blanchard, T. L. (1993). Effects of bilateral ovariectomy via colpotomy in mares: 23 cases (1984-1990). Journal of the American Veterinary Medical Association 203, 1043-1046.
20. Imboden, I., Janett, F., Burger, D., Hässig, M., and Thun, R. (2006). Influence of immunization against GnRH on cycling activity and estrous behaviour in the mare. Theriogenology 66, 1866-1875. doi: 10.1016/j.theriogenology.2006.04.038
21. Jago, J. G., Bass, J. J., and Matthews, L. R. (1997). Evaluation of a vaccine to control bull behaviour. Proceedings of the New Zealand Society of Animal Production 57, 91-95.
22. Janett, F., Lanker, U., Jörg, M., Hässig, M., and Thun, R. (2003). Castration of male lambs by immunisation against GnRH. Schweizer Archiv fucombining double acute accentr Tierheilkunde 145, 291-299. doi: 10.1024/0036-7281.145.6.291
23. Jung, M., Moon, Y., Cho, I., Kim, S., Chang, W. et al. (2005). Induction of castration by immunization of male dogs with recombinant gonadotropin-releasing hormone (GnRH)-canine distemper virus (CDV) T helper cell epitope p 35. Journal of Veterinary Science (Suwon-si, Korea) 6, 21-24.
24. Killian, G., Miller, L., Rhyan, J., and Doten, H. (2006). Immunocontraception of Florida feral swine with a single-dose GnRH vaccine. American Journal of Reproductive Immunology 55, 378-384. doi: 10.1111/j.1600-0897.2006.00379.x
25. Kirkpatrick, J. F., and Turner, A. (2002). Reversibility of action and safety during pregnancy of immunizing against porcine zona pellucida in wild mares (Equus caballus). Reproduction 60(Suppl.), 197-202.
26. Kirkpatrick, J. F., Liu, I. K. M., and Turner, J. (1990). Remotely delivered immunocontraception in feral horses. Wildlife Society Bulletin 18, 326-330.
27. Kirkpatrick, J. F, Perkins, A., and Turner, J. W. (1982). Reversible fertility control in feral horses. Journal of Equine Veterinary Science 2, 114-118. doi: 10.1016/S0737-0806(82)80003-8
28. Levy, J. K., Miller, L. A., Crawford, P. C., Ritchey, J. W., Ross, M. K., and Fagerstone, K. A. (2004). GnRH immunocontraception of male cats. Theriogenology 62, 1116-1130. doi: 10.1016/j.theriogenology.2003. 12.025
29. Malmgren, L., Andresen, O., and Dalin, A. M. (2001). Effect of GnRH immunization on hormonal levels, sexual behaviour, semen quality and testicular morphology in mature stallions. Equine Veterinary Journal 33, 75-83. doi: 10.2746/042516401776767340
30. Miller, L. A., Johns, B. E., Elias, D. J., and Crane, K. A. (1997). Comparative efficacy of two immunocontraceptive vaccines. Vaccine 15, 1858-1862. doi: 10.1016/S0264-410X(97)00141-2
31. Miller, L. A., Johns, B. E., and Killian, G. J. (2000). Immunocontraception of white-tailed deer with GnRH vaccine. American Journal of Reproductive Immunology 44, 266-274. doi: 10.1111/j.8755-8920. 2000.440503.x
32. Miller, L. A., Rhyan, J. C., and Drew, M. (2004). Contraception of bison by GnRH vaccine: a possible means of decreasing transmission of brucellosis in bison. Journal of Wildlife Diseases 40, 725-730.
33. Naugle, R., Rutberg, A. T., Underwood, H. B., Turner, J. W., and Liu, I. K. M. (2002). Field testing of immunocontraception on white-tailed deer (Odocoileus virginianus) on Fire Island National Seashore, U.S.A. Reproduction 60(Suppl.), 143-153.
34. Pavlik, E. J., DePriest, P. D., Gallion, H. H., Ueland, F. R., Reedy, M. B., Kryscio, R. J., and van Nagell, J. R. (2000). Ovarian volume related to age. Gynecologic Oncology 77, 410-412. doi: 10.1006/gyno.2000.5783
35. Robbins, S. C., Jelinski, M. D., and Stotish, R. L. (2004). Assessment of the immunological and biological efficacy of two different doses of a recombinant GnRH vaccine in domestic male and female cats (Felis catus). Journal of Reproductive Immunology 64, 107-119. doi: 10.1016/j.jri.2004.08.004
36. Rutberg, A. T., Naugle, R. E., Thiele, L. A., and Liu, I. K. M. (2004). Effects of immunocontraception on a suburban population of white-tailed deer Odocoileus virginianus. Biological Conservation 116, 243-250. doi: 10.1016/S0006-3207(03)00195-2
37. Skelton, K. V., Dowsett, K. F., and McMeniman, N. P. (1991). Ovarian activity in fillies treated with anabolic steroids prior to the onset of puberty. Journal of Reproduction and Fertility. Supplement 44, 351-356.
38. Stout, T. A. E. (2001). Immunocastration of horses: A tool for behavioural modification. Veterinary Sciences Tomorrow. http://www.vetscite.org/publish/articles/000033/article.html. (accessed on 10 October 2005).
39. Stout, T. A. E., Turkstra, J. A., Meloen, R. H., and Colenbrander, B. (2003). The efficacy of GnRH vaccines in controlling reproductive function in horses. In 'Proceedings of an Expert Consultation on the Control of Wild Elephant Populations'. (Eds B. Colenbrander, J. de Gooier, R. Paling, S. Stout, T. Stout and T. Allen.) pp. 65-67. (Utrecht University: Utrecht, The Netherlands.)
40. Tshewang, U., Dowsett, K. F., Knott, L. M., and Trigg, T. E. (1997). Preliminary study of ovarian activity in fillies treated with GnRH vaccine. Australian Veterinary Journal 75, 663-667.
41. Turkstra, J. A., Meer, F. J. U. M., van der Knaap, J., Rottier, P. J. M., Teerds, K. J., Colenbrander, B., and Meloen, G. H. (2005). Effects of GnRH immunization in sexually mature pony stallions. Animal Reproduction Science 86, 247-259. doi: 10.1016/j.anireprosci.2004.07.010
42. Zeng, X. Y., Turkstra, J. A., Wiel, D. F. M., van de Guo, D. Z., Liu, X. Y., Meloen, R. H., Schaaper, W. M. M., Chen, F. Q., Oonk, H. B., and Zhang, X. (2001). Active immunization against gonadotropin-releasing hormone in Chinese male pigs. Reproduction in Domestic Animals 36, 101-105. doi: 10.1046/j.1439-0531.2001.00256.x