In vivo microscopic features of nodular melanomas: Dermoscopy, confocal microscopy, and histopathologic correlates

Archives of Dermatology

Volumn 144, Issue 10, 2008, Pages 1311-1320

  Segura, Sonia ^a   Pellacani, Giovanni ^b   Puig, Susana ^a   Longo, Caterina ^b   Bassoli, Sara ^b   Guitera, Pascale ^c   Palou, Josep ^a   Menzies, Scott ^c   Seidenari, Stefania ^b   Malvehy, Josep ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CAMERA; CONFOCAL LASER MICROSCOPY; EPILUMINESCENCE MICROSCOPY; HISTOPATHOLOGY; HUMAN; MEDICAL PHOTOGRAPHY; MELANOMA; MICROSCOPE; PRIORITY JOURNAL; SKIN TUMOR; TUMOR CLASSIFICATION; TUMOR DIAGNOSIS;

ADULT; AGED; BIOPSY, NEEDLE; COHORT STUDIES; DERMOSCOPY; EPIDERMIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MICROSCOPY, CONFOCAL; MIDDLE AGED; NEOPLASM STAGING; PROBABILITY; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN NEOPLASMS;

EID: 54349108858     PISSN: 0003987X     EISSN: 0003987X     Source Type: Journal    
DOI: 10.1001/archderm.144.10.1311     Document Type: Article

References (32)

1. Chang AE, Karnell LH, Menck HR; American College of Surgeons Commission on Cancer and the American Cancer Society. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. Cancer. 1998;83(8):1664-1678.
2. Demierre MF, Chung C, Miller DR, Geller AC. Early detection of thick melanomas in the United States: beware of the nodular subtype. Arch Dermatol. 2005;141(6):745-750.
3. Clark WH Jr, From L, Bernardino EA, Mihm MC. The histogenesis and biologic behaviour of primary human malignant melanomas of the skin. Cancer Res. 1969;29(3):705-727.
4. Poetsch M, Woenckhaus C, Dittberner T, Pambor M, Lorenz G, Herrmann FH. Differences in chromosomal aberrations between nodular and superficial spreading malignant melanoma detected by interphase cytogenetics. Lab Invest. 1998;78(7):883-888.
5. Poetsch M, Dittberner T, Woenckhaus C. Can different genetic changes characterize histogenetic subtypes and biologic behaviour in sporadic malignant melanoma of the skin? Cell Mol Life Sci. 2003;60(9):1923-1932.
6. Treszl A, Adány R, Rákosy Z, et al. Extra copies of c-myc are more pronounced in nodular melanomas than in superficial spreading melanomas as revealed by fluorescence in situ hybridisation. Cytometry B Clin Cytom. 2004;60(1):37-46.
7. Curtin JA, Fridlyand J, Kageshita T, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005;353(20):2135-2147.
8. Richard MA, Grob JJ, Avril MF, et al. Delays in diagnosis and melanoma prognosis, II: the role of doctors. Int J Cancer. 2000;89(3):280-285.
9. Brochez L, Verhaeghe E, Bleyen L, Naeyaert JM. Diagnostic ability of general practitioners and dermatologists in discriminating pigmented skin lesions. J Am Acad Dermatol. 2001;44(6):979-986.
10. Chamberlain AJ, Fritschi L, Kelly JW. Nodular melanoma: patients' perceptions of presenting features and implications for earlier detection. J Am Acad Dermatol. 2003;48(5):694-701. doi:10.1067/mjd.2003.216.
11. Pizzichetta MA, Talamini R, Stanganelli I, et al. Amelanotic/ hypomelanotic melanoma: clinical and dermoscopic features. Br J Dermatol. 2004;150(6):1117-1124.
12. Menzies SW. Nodular melanoma. In: Marghoob A, Braun PR, Kopf AW, eds. Atlas of Dermoscopy. London, England: Taylor & Francis; 2005.
13. Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR. In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol. 1995;104(6):946-952.
14. Rajadhyaksha M, González S, Zavislan JM, Anderson RR, Webb RH. In vivo confocal scanning laser microscopy of human skin, II: advances in instrumentation and comparison with histology. J Invest Dermatol. 1999;113(3):293-303.
15. Busam KJ, Hester K, Charles C, et al. Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. Arch Dermatol. 2001;137(7):923-929.
16. Langley RG, Rajadhyasksha M, Dawyer PJ, Sober AJ, Flotte TJ, Anderson RR. Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo. J Am Acad Dermatol. 2001;45(3):365-376.
17. Busam KJ, Charles C, Lohmann CM, Marghoob A, Goldgeier M, Halpern AC. Detection of intraepidermal malignant melanoma in vivo by confocal scanning laser micoscopy. Melanoma Res. 2002;12(4):349-355.
18. Tannous ZS, Mihm MC, Flotte TJ, González S. In vivo examination of lentigo maligna and malignant melanoma in situ, lentigo maligna type by near-infrared reflectance confocal microscopy: comparison of in vivo confocal images with histologic sections. J Am Acad Dermatol. 2002;46(2):260-263.
19. Curiel-Lewandrowski C, Williams CM, Swidells KJ, et al. Use of in vivo confocal microscopy in malignant melanoma: an aid in diagnosis and assessment of surgical and nonsurgical therapeutic approaches. Arch Dermatol. 2004;140(9):1127-1132.
20. Pellacani G, Cesinaro AM, Grana C, Seidenari S. In vivo confocal scanning laser microscopy of pigmented Spitz nevus: comparison of in vivo confocal images with dermoscopy and routine histopathology. J Am Acad Dermatol. 2004;51:371-376.
21. Pellacani G, Cesinaro AM, Seidenari S. In vivo assessment of melanocytic nests in nevi and melanomas by reflectance confocal microscopy. Mod Pathol. 2005;18(4):469.
22. Pellacani G, Cesinaro AM, Longo C, Grana C, Seidenari S. Microscopic in vivo description of cellular architecture of dermoscopic pigmented network in nevi and melanomas. Arch Dermatol. 2005;141(2):147-154.
23. Pellacani G, Cesinaro AM, Seidenari S. Reflectance-mode confocal microscopy for the in vivo characterization of pagetoid melanocytosis in melanomas and nevi. J Invest Dermatol. 2005;125(3):532-537.
24. Pellacani G, Cesinaro AM, Seidenari S. Reflectance-mode confocal microscopy of pigmented skin lesions: improvement in melanoma diagnostic specificity. J Am Acad Dermatol. 2005;53(6):979-985.
25. Gerger A, Koller S, Kern T, et al. Applicability of in vivo confocal laser scanning microscopy in melanocytic skin tumors. J Invest Dermatol. 2005;124(3):493-498.
26. Marghoob AA, Charles CA, Busam KJ, et al. In vivo confocal scanning laser microscopy of a series of congenital melanocytic nevi suggestive of having developed malignant melanoma. Arch Dermatol. 2005;141(11):1401-1412.
27. Langley RG, Burton E, Walsh N, Propperova I, Murray SJ. In vivo confocal scanning laser microscopy of benign lentigines: comparison to conventional histology and in vivo characteristics of lentigo maligna. J Am Acad Dermatol. 2006;55(1):88-97.
28. Gerger A, Koller S, Weger W, et al. Sensitivity and specificity of confocal laser-scanning microscopy for in vivo diagnosis of malignant skin tumors. Cancer. 2006;107(1):193-200.
29. Pellacani G, Guitera P, Longo C, Avramidis M, Seidenari S, Menzies S. The impact of in vivo reflectance confocal microscopy for the diagnostic accuracy of melanoma and equivocal melanocytic lesions. J Invest Dermatol. 2007;127(12):2759-2765.
30. Malvehy J, Puig S, Braun RP, Marghoob AA, Kopf AW, eds. Handbook of Dermoscopy. London, England: Taylor & Francis; 2006.
31. González S, Tannous Z. Real-time in vivo confocal reflectance microscopy of basal cell carcinoma. J Am Acad Dermatol. 2002;47(6):869-874.
32. Nori S, Rius-Díaz F, Cuevas J, et al. Sensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study. J Am Acad Dermatol. 2004;51(6):923-930.