Urine proteomic profiling to identify biomarkers of steroid resistance in pediatric nephrotic syndrome

Expert Review of Proteomics

Volumn 5, Issue 5, 2008, Pages 715-719

  Traum, Avram Z ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Focal segmental glomerulosclerosis; High abundance protein; Nephrotic syndrome; Normal urine proteome; Pediatric; Urine proteomics

Indexed keywords

ALBUMIN; AMMONIA; BIOLOGICAL MARKER; CORTICOSTEROID; IMMUNOGLOBULIN G; PROTEOME; STEROID; TRANSFERRIN; UREA; URIC ACID;

ALBUMIN BLOOD LEVEL; ANTIBIOTIC RESISTANCE; BIOINFORMATICS; CARBAMOYLATION; CHILD; CHILDHOOD DISEASE; CHRONIC KIDNEY DISEASE; CORTICOSTEROID THERAPY; DNA FINGERPRINTING; DRUG MEGADOSE; DRUG RESISTANCE; DRUG RESPONSE; FOCAL GLOMERULOSCLEROSIS; HUMAN; IDIOPATHIC DISEASE; KIDNEY BIOPSY; KIDNEY FAILURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHYLATION; MINIMAL CHANGE GLOMERULONEPHRITIS; NEPHROTIC SYNDROME; PH; PHOSPHORYLATION; PROGNOSIS; PROTEOMICS; REVIEW; URINALYSIS;

ADRENAL CORTEX HORMONES; BIOLOGICAL MARKERS; CHILD; DRUG RESISTANCE; HUMANS; NEPHROTIC SYNDROME; PROTEOMICS;

EID: 54349098965     PISSN: 14789450     EISSN: 17448387     Source Type: Journal    
DOI: 10.1586/14789450.5.5.715     Document Type: Review

References (31)

1. Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney Int. 13(2), 159-165 (1978).
2. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J. Pediatr. 98(4), 561-564 (1981). • Landmark study that characterized the relationship between steroid responsiveness, histology and outcome, and serves as the basis of nephrotic syndrome (NS) therapy today.
3. Schachter AD. Computational simulation of renal biopsy accuracy in focal segmental glomerulosclerosis. Pediatr. Nephrol. 21(7), 953-957 (2006).
4. Schachter AD. The pediatric nephrotic syndrome spectrum: clinical homogeneity and molecular heterogeneity. Pediatr. Transplant. 8(4), 344-348 (2004). • Review of the diverse molecular heterogeneity in NS, including cytokines, angiogenic proteins and structural proteins.
5. Thongboonkerd V, McLeish KR, Arthur JM, Klein JB. Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int. 62(4), 1461-1469 (2002).
6. Conrads TP, Fusaro VA, Ross S et al. High-resolution serum proteomic features for ovarian cancer detection. Endocr. Relat. Cancer 11(2), 163-178 (2004).
7. Pieper R, Gatlin CL, McGrath AM et al. Characterization of the human urinary proteome: a method for high-resolution display of urinary proteins on two-dimensional electrophoresis gels with a yield of nearly 1400 distinct protein spots. Proteomics 4(4), 1159-1174 (2004).
8. Spahr CS, Davis MT, McGinley MD et al. Towards defining the urinary proteome using liquid chromatography-tandem mass spectrometry. I. Profiling an unfractionated tryptic digest. Proteomics 1(1), 93-107 (2001).
9. Weissinger EM, Wittke S, Kaiser T et al. Proteomic patterns established with capillary electrophoresis and mass spectrometry for diagnostic purposes. Kidney Int. 65(6), 2426-2434 (2004).
10. Adachi J, Kumar C, Zhang Y, Olsen JV, Mann M. The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins. Genome Biol. 7(9), R80 (2006).
11. Ransom RF, Lam NG, Hallett MA, Atkinson SJ, Smoyer WE. Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int. 68(6), 2473-2483 (2005). • Differential protein expression of podocytes treated with corticosteroids.
12. Ramjee G, Coovadia HM, Adhikari M. Comparison of noninvasive methods for distinguishing steroid-sensitive nephrotic syndrome from focal glomerulosclerosis. J. Lab. Clin. Med. 129(1), 47-52 (1997).
13. Woroniecki RP, Orlova TN, Mendelev N et al. Urinary proteome of steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome of childhood. Am. J. Nephrol. 26(3), 258-267 (2006).
14. Khurana M, Traum AZ, Aivado M et al. Urine proteomic profiling of pediatric nephrotic syndrome. Pediatr. Nephrol. 21(9), 1257-1265 (2006). •• Identification of b2-microglobulin for distinguishing between steroid-sensitive NS and steroid-resistant NS using urine proteomics.
15. Schaub S, Wilkins JA, Antonovici M et al. Proteomic-based identification of cleaved urinary β2-microglobulin as a potential marker for acute tubular injury in renal allografts. Am. J. Transplant. 5(4 Pt 1), 729-738 (2005).
16. Candiano G, Musante L, Bruschi M et al. Repetitive fragmentation products of albumin and α1-antitrypsin in glomerular diseases associated with nephrotic syndrome. J. Am. Soc. Nephrol. 17(11), 3139-3148 (2006).
17. Erill S, du Souich P, Courteau H. Carbamylation of proteins and sulfacetamide free fraction in serum in experimentally-induced high blood urea states. Res. Commun. Chem. Pathol. Pharmacol. 50(1), 45-56 (1985).
18. Lippincott J, Apostol I. Carbamylation of cysteine: a potential artifact in peptide mapping of hemoglobins in the presence of urea. Anal. Biochem. 267(1), 57-64 (1999).
19. Osterberg R, Orgel LE, Lohrmann R. Further studies of urea-catalyzed phosphorylation reactions. J. Mol. Evol. 2(2-3), 231-234 (1973).
20. Strak GR, Link TP. Preparation and properties of three specific active derivatives of ribonuclease A obtained by methylation of methionine residues in 8 M urea. Biochemistry 14(15), 4576-4581 (1975).
21. Filipe P, Haigle J, Freitas J et al. Anti- and pro-oxidant effects of urate in copper-induced low-density lipoprotein oxidation. Eur. J. Biochem. 269(22), 5474-5483 (2002).
22. Schlotte V, Sevanian A, Hochstein P, Weithmann KU. Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein in vitro. Free Radic. Biol. Med. 25(7), 839-847 (1998).
23. Llansola M, Erceg S, Felipo V. Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture. Neuroscience 133(1), 185-191 (2005).
24. Schliess F, Gorg B, Fischer R et al. Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes. FASEB J. 16(7), 739-741 (2002).
25. Murthy CR, Hertz L. Acute effect of ammonia on branched-chain amino acid oxidation and incorporation into proteins in astrocytes and in neurons in primary cultures. J. Neurochem. 49(3), 735-741 (1987).
26. Murthy CR, Hertz L. Comparison between acute and chronic effects of ammonia on branched-chain amino acid oxidation and incorporation into protein in primary cultures of astrocytes and of neurons. J. Neurosci. Res. 17(3), 271-276 (1987).
27. Reaich D, Channon SM, Scrimgeour CM, Goodship TH. Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. Am. J. Physiol. 263(4 Pt 1), E735-E739 (1992).
28. Liotta LA, Ferrari M, Petricoin E. Clinical proteomics: written in blood. Nature 425(6961), 905 (2003). • Addresses concerns over loss of low-molecular-weight proteins with albumin depletion.
29. Harper RG, Workman SR, Schuetzner S, Timperman AT, Sutton JN. Low-molecular-weight human serum proteome using ultrafiltration, isoelectric focusing, and mass spectrometry. Electrophoresis 25(9), 1299-1306 (2004). •• Novel approach for removing high-abundance, high-molecular-weight plasma proteins.
30. NAPRTCS 2006 Annual Report. (North American Pediatric Renal Trials and Collaborative Studies, 2006) www.naprtcs.org
31. The Plasma Proteome Institute www.plasmaproteome.org (Accessed 8 September 2005)