A multi-center prospective, randomized, double-blind trial studying the effect of misoprostol on the outcome of intrauterine insemination

Gynecologic and Obstetric Investigation

Volumn 66, Issue 3, 2008, Pages 145-151

  Billiet, Kelly ^a   Dhont, Marc ^a   Vervaet, Chris ^b   Vermeire, An ^b   Gerris, Jan ^a,c   De Neubourg, Diane ^c   Delbeke, Luc ^d   Ombelet, Willem ^e   De Sutter, Petra ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

^c MIDDELHEIM HOSPITAL   (Belgium)

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^e Genk Institute of Fertility Technology   (Belgium)

Author keywords

Intrauterine insemination; Misoprostol; Pregnancy; Prostaglandin; Vaginal suppository

Indexed keywords

CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; GONADOTROPIN DERIVATIVE; HUMAN MENOPAUSAL GONADOTROPIN; MISOPROSTOL; PLACEBO; RECOMBINANT FOLLITROPIN;

ABDOMINAL PAIN; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG TREATMENT FAILURE; FEMALE; FEMALE INFERTILITY; HUMAN; INTRAUTERINE INSEMINATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; PREGNANCY RATE; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VAGINA BLEEDING;

ABDOMINAL PAIN; ADMINISTRATION, INTRAVAGINAL; ADULT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INSEMINATION, ARTIFICIAL; MALE; MISOPROSTOL; PREGNANCY; PROSPECTIVE STUDIES; PROSTAGLANDINS, SYNTHETIC; UTERINE HEMORRHAGE; YOUNG ADULT;

EID: 54349093067     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000133951     Document Type: Article

References (17)

1. Troedsson MHT, Desvousges A, Alghamndi AS, Dahms B, Dow CA, Hayna J, et al: Components in seminal plasma regulating sperm transport and elimination. Anim Reprod Sci 2005;89:171-186.
2. 2 prior to insemination of mares in the uterine horn or body. Theriogenology 2000;53:1827-1836.
3. Brown SE, Toner JP, Schnorr JA, Williams SC, Gibbons WE, De Ziegler D, et al: Vaginal misoprostol enhances intrauterine insemination. Hum Reprod 2001;16:96-101.
4. De Sutter P, Veldeman L, Kok P, Szymczak N, Van Der Elst J, Dhont M: Comparison of outcome of pregnancy after intrauterine insemination and IVF. Hum Reprod 2005;20:1642-1646.
5. Norman GR, Daya S: The alternating-sequence design (or multiple-period crossover) trial for evaluating treatment efficacy in infertility. Fertil Steril 2000;74:319-324.
6. Bygdeman M, Gottlieb C, Svanborg K, Swahn ML: Role of prostaglandins in human reproduction: recent advances. Adv Prostaglandin Thromboxane Leukot Res 1987;17B:1112-1116.
7. Aitken RJ, Kelly RW: Analysis of the direct effects of prostaglandins on human sperm function. J Reprod Fertil 1985;73:139-146.
8. Michael R, Younan N, Guindi A, Abadir A: Human seminal prostaglandins and male fertility. Proc West Pharmacol Soc 2001;44:141-143.
9. Robertson SA: Seminal plasma and male factor signalling in the female reproductive tract. Cell Tissue Res 2005;322:43-52.
10. Sahmay S, Atasu T, Karacan I: The effect of intrauterine insemination on uterine activity. Int J Fertil 1990;35:310-314.
11. Weeks AD, Fiala C, Safar P: Misoprostol and the debate over off-label drug use. BJOG 2005;112:269-272.
12. Preutthipan S, Herabuta Y: A randomized comparison of vaginal misoprostol and dinoprostone for cervical priming in nulliparous women before operative hysteroscopy. Fertil Steril 2006;86:990-994.
13. Zieman M, Fong SK, Benowitz NL, Banskter D, Darney PD: Absorption kinetics of misoprostol with oral or vaginal administration. Obstet Gynecol 1997;90:88-92.
14. Danielsson KG, Marions L, Rodriguez A, Spur BW, Wong PYK, Bygdeman M: Comparison between oral and vaginal administration of misoprostol on uterine contractility. Obstet Gynecol 1999;93:275-280.
15. Aronsson A, Bygdeman M, Gemzell-Danielsonn K: Effects of misoprostol on uterine contractility following different routes of administration. Hum Reprod 2004;19:81-84.
16. Toner J, de Ziegler D, Brown S, Gibbons WE, Oehninger S, Schnorr JA, et al: High rates of cramping with misoprostol administration for intrauterine insemination. Hum Reprod 2001;16:1051.
17. McDonnell J, Goverde AJ, Vermeiden JPW: The place of the crossover design in infertility trials: a maximum likelihood approach. Hum Reprod 2004;19:2537-2544.