Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats

Brazilian Journal of Medical and Biological Research

Volumn 41, Issue 9, 2008, Pages 804-808

  Brito, J O ^a   Ponciano, K ^a   Figueroa, D ^a   Bernardes, N ^a   Sanches, I C ^a   Irigoyen, M C ^b   De Angelis, K ^a,c  

^a SÃO JUDAS TADEU UNIVERSITY   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE   (Brazil)

Author keywords

Blood pressure; Female rats; Fructose; Insulin resistance; Parasympathetic nervous system

Indexed keywords

ATROPINE; FRUCTOSE; GLUCOSE; PROPRANOLOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC DYSFUNCTION; CARBOHYDRATE DIET; CARDIOVASCULAR DISEASE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HEART RATE; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; METABOLIC DISORDER; NONHUMAN; PATHOPHYSIOLOGY; RAT; VAGUS TONE; WEIGHT GAIN; WISTAR RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 54349088570     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2008005000030     Document Type: Article

References (18)

1. Basciano H, Federico L, Adeli K. Fructose, insulin resistance, and metabolic dyslipidemia. Nutr Metab 2005; 2: 5.
2. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 2002; 76: 911-922.
3. Cunha TS, Farah V, Paulini J, Pazzine M, Elased KM, Marcondes FK, et al. Relationship between renal and cardiovascular changes in a murine model of glucose intolerance. Regul Pept 2007; 139: 1-4.
4. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 1987; 10: 512-516.
5. Farah V, Elased KM, Chen Y, Key MP, Cunha TS, Irigoyen MC, et al. Nocturnal hypertension in mice consuming a high fructose diet. Auton Neurosci 2006; 130: 41-50.
6. Verma S, Bhanot S, McNeill JH. Sympathectomy prevents fructose-induced hyperinsulinemia and hypertension. Eur J Pharmacol 1999; 373: R1-R4.
7. De Angelis Lobo d'Avila K, Gadonski G, Fang J, Dall'Ago P, Albuquerque VL, Peixoto LR, et al. Exercise reverses peripheral insulin resistance in trained L-NAME-hypertensive rats. Hypertension 1999; 34: 768-772.
8. Vasudevan H, Xiang H, McNeill JH. Differential regulation of insulin resistance and hypertension by sex hormones in fructose-fed male rats. Am J Physiol Heart Circ Physiol 2005; 289: H1335-H1342.
9. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, et al. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 1989; 68: 374-378.
10. De Angelis KL, Oliveira AR, Dall'Ago P, Peixoto LR, Gadonski G, Lacchini S, et al. Effects of exercise training on autonomic and myocardial dysfunction in streptozotocindiabetic rats. Braz J Med Biol Res 2000; 33: 635-641.
11. Galipeau D, Verma S, McNeill JH. Female rats are protected against fructose-induced changes in metabolism and blood pressure. Am J Physiol Heart Circ Physiol 2002; 283: H2478-H2484.
12. Song D, Arikawa E, Galipeau D, Battell M, McNeill JH. Androgens are necessary for the development of fructose-induced hypertension. Hypertension 2004; 43: 667-672.
13. D'Angelo G, Elmarakby AA, Pollock DM, Stepp DW. Fructose feeding increases insulin resistance but not blood pressure in Sprague-Dawley rats. Hypertension 2005; 46: 806-811.
14. Verma S, Bhanot S, Yao L, McNeill JH. Defective endothelium-dependent relaxation in fructose-hypertensive rats. Am J Hypertens 1996; 9: 370-376.
15. Souza SB, Flues K, Paulini J, Mostarda C, Rodrigues B, Souza LE, et al. Role of exercise training in cardiovascular autonomic dysfunction and mortality in diabetic ovariectomized rats. Hypertension 2007; 50: 786-791.
16. Evans JM, Ziegler MG, Patwardhan AR, Ott JB, Kim CS, Leonelli FM, et al. Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes. J Appl Physiol 2001; 91: 2611-2618.
17. Miller AW, Sims JJ, Canavan A, Hsu T, Ujhelyi MR. Impaired vagal reflex activity in insulin-resistant rats. J Cardiovasc Pharmacol 1999; 33: 698-702.
18. Valensi P, Nguyen TN, Idriss S, Cazes P, Karam G, Paries J, et al. Influence of parasympathetic dysfunction and hyperinsulinemia on the hemodynamic response to an isometric exercise in non-insulin-dependent diabetic patients. Metabolism 1998; 47: 934-939.