Osteitis fibrosa is mediated by platelet-derived growth factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism

Endocrinology

Volumn 149, Issue 11, 2008, Pages 5735-5746

  Lowry, Malcolm B ^a   Lotinun, Sutada ^a,c   Leontovich, Alexey A ^b   Zhang, Minzhi ^b   Maran, Avudaiappan ^b   Shogren, Kristen L ^b   Palama, Brett K ^a   Marley, Kevin ^a   Iwaniec, Urszula T ^a   Turner, Russell T ^a  

^a OREGON STATE UNIVERSITY   (United States)

^b MAYO CLINIC   (United States)

^c HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPIONITRILE; BONE MORPHOGENETIC PROTEIN; IMATINIB; PARATHYROID HORMONE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR A; PROTEIN LYSINE 6 OXIDASE; TRAPIDIL; WNT PROTEIN; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; GENE EXPRESSION PROFILING; GENE FUNCTION; HYPERPARATHYROIDISM; IMMUNOHISTOCHEMISTRY; MORPHOMETRICS; MYELOFIBROSIS; NONHUMAN; OSTEITIS FIBROSA; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CHRONIC DISEASE; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HYPERPARATHYROIDISM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEITIS FIBROSA CYSTICA; PARATHYROID HORMONE; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 54349086568     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0134     Document Type: Article

References (47)

1. Dobnig H, Turner RT 1995 Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 136:3632-3638
2. Ishizuya T, Yokose S, Hori M, Noda T, Suda T, Yoshiki S, Yamaguchi A 1997 Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells. J Clin Invest 99:2961-2970
3. Kaiser E, Sato M, Onyia JE, Chandrasekhar S 2001 Parathyroid hormone (1-34) regulates integrin expression in vivo in rat osteoblasts. J Cell Biochem 83:617-630
4. Locklin RM, Khosla S, Turner RT, Riggs BL 2003 Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone. J Cell Biochem 89:180-190
5. Lotinun S, Sibonga JD, Turner RT 2002 Differential effects of intermittent and continuous administration of parathyroid hormone on bone histomorphometry and gene expression. Endocrine 17:29-36
6. Lotinun S, Sibonga JD, Turner RT 2005 Evidence that the cells responsible for marrow fibrosis in a rat model for hyperparathyroidism are preosteoblasts. Endocrinology 146:4074-4081
7. Tam CS, Heersche JN, Murray TM, Parsons JA 1982 Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration. Endocrinology 110:506-512
8. Dobnig H, Turner RT 1997 The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. Endocrinology 138:4607-4612
9. Khan A, Bilezikian J 2000 Primary hyperparathyroidism: pathophysiology and impact on bone. CMAJ 163:184-187
10. Ferreira A 2006 Development of renal bone disease. Eur J Clin Invest 36(Suppl 2):2-12
11. Bilezikian JP, Meng X, Shi Y, Silverberg SJ 2000 Primary hyperparathyroidism in women: a tale of two cities - New York and Beijing. Int J Fertil Womens Med 45:158-165
12. Silverberg SJ, Bilezikian JP 2001 Clinical presentation of primary hyperparathyroidism in the United States. In: Bilezikian JP, Marcus R, Levine MA, eds. The parathyroids: basic and clinical concepts. 2nd ed. San Diego: Academic Press; 349-360
13. Elder G 2002 Pathophysiology and recent advances in the management of renal osteodystrophy. J Bone Miner Res 17:2094-2105
14. Li X, Liu H, Qin L, Tamasi J, Bergenstock M, Shapses S, Feyen JH, Notterman DA, Partridge NC 2007 Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem 282:33086-33097
15. Onyia JE, Helvering LM, Gelbert L, Wei T, Huang S, Chen P, Dow ER, Maran A, Zhang M, Lotinun S, Lin X, Halladay DL, Miles RR, Kulkarni NH, Ambrose EM, Ma YL, Frolik CA, Sato M, Bryant HU, Turner RT 2005 Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: an analysis by DNA microarray. J Cell Biochem 95:403-418
16. Lotinun S, Sibonga JD, Turner RT 2003 Triazolopyrimidine (trapidil), a platelet-derived growth factor antagonist, inhibits parathyroid bone disease in an animal model for chronic hyperparathyroidism. Endocrinology 144:2000-2007
17. Qin L, Qiu P, Wang L, Li X, Swarthout JT, Soteropoulos P, Tolias P, Partridge NC 2003 Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblasts revealed by microarray and bioinformatics. J Biol Chem 278:19723-19731
18. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
19. Huffman MD, Curci JA, Moore G, Kerns DB, Starcher BC, Thompson RW 2000 Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery 128:429-438
20. Bonnelye E, Merdad L, Kung V, Aubin JE 2001 The orphan nuclear estrogen receptor-related receptor alpha (ERRα) is expressed throughout osteoblast differentiation and regulates bone formation in vitro. J Cell Biol 153:971-984
21. Baron R, Vignery A, Neff L, Silvergate A, Santa Maria A 1983 Processing of undecalcified bone specimens for bone histomorphometry. In: Recker RR, ed. Bone histomorphometry: techniques and interpretation. Boca Raton, FL: CRC Press; 13-35
22. Daddow LY 1986 An abbreviated method of the double lead stain technique. J Submicrosc Cytol 18:221-224
23. Kulkarni NH, Halladay DL, Miles RR, Gilbert LM, Frolik CA, Galvin RJ, Martin TJ, Gillespie MT, Onyia JE 2005 Effects of parathyroid hormone on Wnt signaling pathway in bone. J Cell Biochem 95:1178-1190
24. Bando K, Kannuki S, Rokutan K, Shouno M, Matsumoto K 1995 Effects of trapidil and suramin on growth factor-induced calcium response and tyrosine phosphorylation in human glioma cells. Neurol Med Chir (Tokyo) 35:631-638
25. Mazurov AV, Menshikov M, Leytin VL, Tkachuk VA, Repin VS 1984 Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil. FEBS Lett 172:167-171
26. Ohnishi H, Kosuzume H, Hayashi Y, Yamaguchi K, Suzuki Y, Itoh R 1981 Effects of trapidil on thromboxane A2-induced aggregation of platelets, ischemic changes in heart and biosynthesis of thromboxane A2. Prostaglandins Med 6:269-281
27. Zhou L, Ismaili J, Stordeur P, Thielemans K, Goldman M, Pradier O 1999 Inhibition of the CD40 pathway of monocyte activation by triazolopyrimidine. Clin Immunol 93:232-238
28. Bonisch D, Weber AA, Wittpoth M, Osinski M, Schror K 1998 Antimitogenic effects of trapidil in coronary artery smooth muscle cells by direct activation of protein kinase A. Mol Pharmacol 54:241-248
29. O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P, Grey A 2007 Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J Bone Miner Res 22:1679-1689
30. Koslowski R, Seidel D, Kuhlisch E, Knoch KP 2003 Evidence for the involvement of TGF-β and PDGF in the regulation of prolyl 4-hydroxylase and lysyloxidase in cultured rat lung fibroblasts. Exp Toxicol Pathol 55:257-264
31. Rodgers K, McMahon B, Mitchell D, Sadlier D, Godson C 2005 Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. Am J Pathol 167:683-694
32. Jimenez C, Portela RA, Mellado M, Rodriguez-Frade JM, Collard J, Serrano A, Martinez AC, Avila J, Carrera AC 2000 Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol 151:249-262
33. Kim SJ, Kim SY, Kwon CH, Kim YK 2007 Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells. Growth factors 25:77-86
34. Onishi K, Higuchi M, Asakura T, Masuyama N, Gotoh Y 2007 The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts. Genes Cells 12:535-546
35. Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ 2007 PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest 117:730-738
36. Yamamoto T, Kambe F, Cao X, Lu X, Ishiguro N, Seo H 2007 Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells. Bone 40:354-359
37. Kagan HM 1994 Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis. Pathol Res Pract 190:910-919
38. van der Slot AJ, Zuurmond AM, van den Bogaerdt AJ, Ulrich MM, Middelkoop E, Boers W, Karel Ronday H, DeGroot J, Huizinga TW, Bank RA 2004 Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon. Matrix Biol 23:251-257
39. Erler JT, Giaccia AJ 2006 Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res 66:10238-10241
40. Akiri G, Sabo E, Dafni H, Vadasz Z, Kartvelishvily Y, Gan N, Kessler O, Cohen T, Resnick M, Neeman M, Neufeld G 2003 Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo. Cancer Res 63:1657-1666
41. Uzel MI, Shih SD, Gross H, Kessler E, Gerstenfeld LC, Trackman PC 2000 Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones. J Bone Miner Res 15:1189-1197
42. Medeck RJ, Sosa S, Morris N, Oxford JT 2003 BMP-1-mediated proteolytic processing of alternatively spliced isoforms of collagen type XI. Biochem J 376:361-368
43. Lee HX, Ambrosio AL, Reversade B, De Robertis EM 2006 Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell 124:147-159
44. Jiang F, Parsons CJ, Stefanovic B 2006 Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45:401-409
45. Surendran K, McCaul SP, Simon TC 2002 A role for Wnt-4 in renal fibrosis. Am J Physiol Renal Physiol 282:F431-F441
46. Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M 2005 Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 23:749-786
47. Pejler G, Abrink M, Ringvall M, Wernersson S 2007 Mast cell proteases. Adv Immunol 95:167-255