JAK2-a new player in acute lymphoblastic leukaemia

The Lancet

Volumn 372, Issue 9648, 2008, Pages 1448-1450

  Mullighan, Charles G ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 2; TRANSCRIPTION FACTOR GATA 1;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SUBSTITUTION; ARTICLE; CHROMOSOME TRANSLOCATION; CLINICAL FEATURE; DISEASE ASSOCIATION; DOWN SYNDROME; ENZYME ACTIVATION; GENE MUTATION; HEMATOLOGIC DISEASE; HUMAN; MYELOPROLIFERATIVE DISORDER; PHENOTYPE; PRIORITY JOURNAL;

EID: 54249169461     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(08)61342-2     Document Type: Note

References (12)

1. Pui C.H., Relling M.V., and Downing J.R. Acute lymphoblastic leukemia. N Engl J Med 350 (2004) 1535-1548
2. Bercovich D., Ganmore I., Scott L.M., et al. Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet (2008) 10.1016/S0140-6736(08)61341-0 published online Sept 20.
3. Zwaan M.C., Reinhardt D., Hitzler J., and Vyas P. Acute leukemias in children with Down syndrome. Pediatr Clin North Am 55 (2008) 53-70
4. Arico M., Ziino O., Valsecchi M.G., et al., for the Italian Association of Pediatric Hematology and Oncology (AIEOP). Acute lymphoblastic leukemia and Down syndrome: presenting features and treatment outcome in the experience of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Cancer 113 (2008) 515-521
5. Levine R.L., Pardanani A., Tefferi A., and Gilliland D.G. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat Rev Cancer 7 (2007) 673-683
6. Lacronique V., Boureux A., Valle V.D., et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278 (1997) 1309-1312
7. Malinge S., Ben-Abdelali R., Settegrana C., et al. Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia. Blood 109 (2007) 2202-2204
8. Wiemels J.L., Cazzaniga G., Daniotti M., et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet 354 (1999) 1499-1503
9. Jeong E.G., Kim M.S., Nam H.K., et al. Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers. Clin Cancer Res 14 (2008) 3716-3721
10. Flex E., Petrangeli V., Stella L., et al. Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med 205 (2008) 751-758
11. Mullighan C.G., Goorha S., Radtke I., et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446 (2007) 758-764
12. Lo K.C., Chalker J., Strehl S., et al. Array comparative genome hybridization analysis of acute lymphoblastic leukaemia and acute megakaryoblastic leukaemia in patients with Down syndrome. Br J Haematol (2008) 10.1111/j.1365-2141.2008.07280.x published online June 13.