Effect of thiols on cadmium-induced expression of metallothionein and other oxidant stress genes in rat lung epithelial cells

Toxicology

Volumn 119, Issue 3, 1997, Pages 179-191

  Gong, Q ^a   Hart, B A ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Cadmium; Gene expression; Glutathione; Glutathione S transferase Ya; Heme oxygenase 1; Lung epithelial cells; Metallothionein 1

Indexed keywords

BUTHIONINE SULFOXIMINE; CADMIUM; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE; MESSENGER RNA; METALLOTHIONEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; GENE EXPRESSION; IN VITRO STUDY; INTOXICATION; LUNG ALVEOLUS EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS;

ACETYLCYSTEINE; ANIMALS; BUTHIONINE SULFOXIMINE; CADMIUM CHLORIDE; CARCINOGENS; CELL DEATH; CELL LINE; DNA PROBES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; GENE EXPRESSION; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEME OXYGENASE (DECYCLIZING); KINETICS; LUNG; METALLOTHIONEIN; OXIDOREDUCTASES; RATS; RNA, MESSENGER;

ANIMALIA;

EID: 0030984664     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(96)03608-6     Document Type: Article

References (36)

1. Alam, J., Cai, J. and Smith, A. (1994) Isolation and characterization of the mouse heme oxygenase-1 gene. J. Biol. Chem. 269, 1001-1009.
2. Andersen, R.D., Birren, B.W., Gang, T., Piletz, J.E. and Herschman, H.R. (1983) Molecular cloning of the rat metallothionein (MT-1) mRNA sequence. DNA 2, 15-22.
3. Bergelson, S., Pinkus, R. and Daniel, V. (1994a) Intracellular glutathione levels regulated Fos/Jun induction and activation of glutathione S-transferase gene expression. Cancer Res. 54, 36-40.
4. Bergelson, S., Pinkus, R. and Daniel, V. (1994b) Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression. Oncogene 9, 565-571.
5. Choi, A.M.K. and Alam, J. (1996) Heme oxygenase-1: function, regulation, and induction of a novel stress-inducible protein in oxidant-induced lung injury. Am. J. Respir. Cell Mol. Biol. 15, 9-19.
6. Chubatsu, L.S. and Meneghini, R. (1993) Metallothionein protects DNA from oxidative damage. Biochem. J. 291, 193-198.
7. Dalton, T., Palmiter, R.D. and Andrews, G. (1994) Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res. 22, 5016-5023.
8. Daniel, V. (1993) Glutathione S-transferases: gene structure and regulation of expression. Crit. Rev. Biochem. Mol. Biol. 28, 173-207.
9. Dwivedi, R.S., Primiano, T. and Novak, R.F. (1993) Xenobiotic-modulated expression of hepatic glutathione S-transferase genes in primary rat hepatocyte culture. Biochim. Biophys. Acta. 1174, 43-53.
10. Farber, E. and Rubin, H. (1991) Cellular adaptation in the origin and development of cancer. Cancer Res. 51, 2751-2761.
11. Gallagher, E.P., Kavanagh, T.J. and Eaton, D. (1994) Glutathione, oxidized glutathione, and mixed disulfides in biological samples. In: C.A. Tyson and J.M. Frazier (Eds.), Methods in Toxicology. Academic Press, Inc., San Diego, Vol. 1B, pp. 349-366.
12. Hansen, M.B., Nielsen, S.E. and Berg, K. (1989) Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119, 203-210.
13. Hart, B.A. (1986) Cellular and biochemical response of the rat lung to repeated inhalation of cadmium aerosols. Toxicol. Appl. Pharmacol. 82, 281-291.
14. Hart, B.A., Voss, G.W. and Willean, C.L. (1989) Pulmonary tolerance to cadmium following cadmium aerosol pretreatment. Toxicol. Appl. Pharmacol. 101, 447-460.
15. Hart, B.A., Voss, G.W., Shatos, M.A. and Doherty, J. (1990) Cross-tolerance to hyperoxia following cadmium aerosol pretreatment. Toxicol. Appl. Pharmacol. 103, 255-270.
16. Hart, B.A., Gong, Q., Eneman, J.D. and Durieux-Lu, C.-C. (1995a) In vivo expression of metallothionein in rat alveolar macrophages and type II epithelial cells following repeated cadmium aerosol exposures. Toxicol. Appl. Pharmacol. 133, 82-90.
17. Hart, B.A., Eneman, J.D., Gong, Q. and Durieux-Lu, C.-C. (1995b) Increased oxidant resistance of alveolar epithelial type II cells isolated from rats following repeated exposure to cadmium aerosols. Toxicol. Lett. 81, 131-139.
18. Hart, B.A., Gong, Q., Eneman, J.D., Durieux-Lu, C.-C., Kimberly, P. and Hacker, M.P. (1996a) Increased oxidant resistance of alveolar macrophages isolated from rats repeatedly exposed to cadmium aerosols. Toxicology 107, 163-175.
19. Hart, B.A., Gong, Q. and Eneman, J.D. (1996b) Pulmonary metallothionein expression in rats following single and repeated exposure to cadmium oxide aerosols. Toxicology 110, 1-14.
20. IARC (1993) International Agency for Research on Cancer, Monographs on the Evaluation of the Carcinogenic Risks to Human, Vol. 58, Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. IARC Scientific Publications, Lyon, France, pp. 119-238.
21. Lautier, D., Luscher, P. and Tyrrell, R.M. (1992) Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene. Carcinogenesis 13, 227-232.
22. Li, A.P., Hahn, F.F., Zamora, P.O., Shimizu, R.W., Henderson, R.F., Brooks, A.L. and Richards, R. (1983) Characterization of a lung epithelial cell strains with potential applications in toxicological studies. Toxicology 27, 257-272.
23. McKim, J.M. Jr., Liu, J., Liu, Y.P. and Klaassen, C.D. (1992) Induction of metallothionein by cadmium-metallothionein in rat liver: A proposed mechanism. Toxicol. Appl. Pharmacol. 112, 318-323.
24. Meister, A. (1991) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy. Pharmacol. Ther. 51, 155-194.
25. Moldeus, P. and Cotgreave, I.A. (1994) Antioxidant characterization and assay. N-acetylcysteine. Methods Enzymol. 234, 482-492.
26. Otterbein, L., Sylvester, S.L. and Choi, A.M.K. (1995) Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am. J. Respir. Cell Mol. Biol. 13, 595-601.
27. Palmiter, R.D. (1994) Regulation of metallothionein genes by heavy metals appears to be mediated by a zinc-sensitive inhibitor that interacts with a constitutively active transcription factor, MTF-1. Proc. Natl. Acad. Sci. USA 91, 1219-1223.
28. Radtke, F., Georgiev, O., Muller, H.-P., Brugnera, E. and Schaffner, W. (1995) Functional domains of the heavy metal-responsive transcription regulator MTF-1. Nucleic Acids Res. 23, 2277-2286.
29. Ren, Y. and Smith, A. (1995) Mechanism of metallothionein gene regulation by heme-hemopexin. Roles of protein kinase C, reactive oxygen species, and cis-acting elements. J. Biol. Chem. 270, 23988-23995.
30. Sato, M. and Bremner, I. (1993) Oxygen free radicals and metallothionein. Free Radical Biol. Med. 14, 325-337.
31. Schwarz, M.A., Lazo, J.S., Yalowich, J.C., Reynolds, I., Kagan, V.E., Tyurin, V., Kim, Y.-M., Watkines, S.C. and Pitt, B.R. (1994) Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem. 269, 15238-15243.
32. Stuart, G.W., Searle, P.F. and Palmiter, R.D. (1985) Identification of multiple metal regulatory elements in mouse metallothionein-I promoter by assaying synthetic sequences. Nature 317, 828-831.
33. Takenaka, S., Oldiges, H., Konig, H., Hochrainer, D. and Oberdoster, G. (1983) Carcinogenicity of cadmium chloride aerosols in Wistar rats. J. Natl. Cancer Inst. 70, 367-373.
34. Thornalley, P.J. and Vasak, M. (1985) Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochim. Biophys. Acta 827, 36-44.
35. Vile, G.F., Basu-Modak, S., Waltner, C. and Tyrrell, R.M. (1994) Heme oxygenase 1 mediates an adaptive response to oxidative stress in human skin fibroblasts. Proc. Natl. Acad. Sci. USA 91, 2607-2610.
36. Waalkes, M.P. and Goering, P.L. (1990) Metallothionein and other Cd binding proteins: Recent developments. Chem. Res. Toxicol. 3, 281-288.