Reduction of asymmetric dimethylarginine in the protective effects of rutaecarpine on gastric mucosal injury

Canadian Journal of Physiology and Pharmacology

Volumn 86, Issue 10, 2008, Pages 675-681

  Liu, Ying Zi ^a,b   Zhou, Yuan ^b   Li, Dai ^a   Wang, Li ^a   Hu, Gao Yun ^a   Peng, Jun ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

ADMA; Asymmetric dimethylarginine; Calcitonin gene related peptide; CGRP; DDAH; Dimethylarginine dimethylaminohydrolase; Gastric ulcer; Rutaecarpine

Indexed keywords

ALCOHOL; CALCITONIN GENE RELATED PEPTIDE; CAPSAZEPINE; DIMETHYLARGININASE; N(G) NITROARGININE METHYL ESTER; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; RUTAECARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STOMACH MUCOSA; STOMACH MUCOSA INJURY; STOMACH PROTECTION;

AMIDOHYDROLASES; ANIMALS; ANTI-ULCER AGENTS; ARGININE; CALCITONIN GENE-RELATED PEPTIDE; ENZYME INHIBITORS; ETHANOL; GASTRIC MUCOSA; INDICATORS AND REAGENTS; INDOLE ALKALOIDS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTECTIVE AGENTS; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER;

EID: 54249143015     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y08-073     Document Type: Article

References (26)

1. Berg, A., Redeen, S., Ericson, A.C., and Sjostrand, S.E. 2004. Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands. BMC Gastroenterol. 4: 16. doi:10.1186/1471-230X-4-16. PMID:15298720.
2. Berg, A., Redeen, S., Sjostrand, S.E., and Ericson, A.C. 2007. Effect of nitric oxide on histamine-induced cytological transformations in parietal cells in isolated human gastric glands. Dig. Dis. Sci. 52: 126-136. doi:10.1007/s10620-006-9439-z. PMID:17171449.
3. Boger, R.H. 2003. The emerging role of asymmetric dimethylarginine as a novel cardiovascular risk factor. Cardiovasc. Res. 59: 824-833. doi:10.1016/S0008-6363(03)00500-5. PMID:14553822.
4. Chuang, W.C., Cheng, C.M., Chang, H.C., Chen, Y.P., and Sheu, S.J. 1999. Contents of constituents in mature and immature fruits of evodia species. Planta Med. 65: 567-571. doi:10.1055/s-1999-14028. PMID:17260282.
5. Dayoub, H., Achan, V., Adimoolam, S., Jacobi, J., Stuehlinger, M.C., Wang, B.Y., et al. 2003. Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation, 108: 3042-3047. doi:10.1161/01.CIR.0000101924.04515.2E. PMID:14638548.
6. Deng, P.Y., and Li, Y.J. 2005. Calcitonin gene-related peptide and hypertension. Peptides, 26: 1676-1685. doi:10.1016/j.peptides.2005.02. 002. PMID:16112410.
7. Deng, P.Y., Ye, F., Cai, W.J., Tan, G.S., Hu, C.P., Deng, H.W., and Li, Y.J. 2004. Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine. J. Hypertens. 22: 1819-1829. doi:10.1097/00004872-200409000-00028. PMID:15311112.
8. Domotor, A., Peidl, Z., Vincze, A., Hunyady, B., Szolcsanyi, J., Kereskay, L., et al. 2005. Immunohistochemical distribution of vanilloid receptor, calcitonin-gene related peptide and substance P in gastrointestinal mucosa of patients with different gastrointestinal disorders. Inflammopharmacology, 13: 161-177. doi:10.1163/156856005774423737. PMID:16259736.
9. Feng, Q., Lu, X., Jones, D.L., Shen, J., and Arnold, J.M. 2001. Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice. Circulation, 104: 700-704. doi:10.1161/hc3201.092284. PMID:11489778.
10. Guth, P.H., Aures, D., and Paulsen, G. 1979. Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Gastroenterology, 76: 88-93. PMID:361495.
11. Holzer, P. 2007. Role of visceral afferent neurons in mucosal inflammation and defense. Curr. Opin. Pharmacol. 7: 563-569. doi:10.1016/j.coph.2007.09.004. PMID:18029228.
12. Ito, A., Tsao, P.S., Adimoolam, S., Kimoto, M., Ogawa, T., and Cooke, J.P. 1999. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation, 99: 3092-3095. PMID:10377069.
13. Kaneko, H., Mitsuma, T., Nagai, H., Mori, S., Iyo, T., Kusugami, K., and Tache, Y. 1998. Central action of adrenomedullin to prevent ethanol-induced gastric injury through vagal pathways in rats. Am. J. Physiol. 274: R1783-R1788. PMID:9841551.
14. Li, D., Xia, K., Li, N.S., Luo, D., Wang, S., Jiang, D.J., et al. 2007. Reduction of asymmetric dimethylarginine involved in the cardioprotective effect of losartan in spontaneously hypertensive rats. Can. J. Physiol. Pharmacol. 85: 783-789. doi:10.1139/Y07-073. PMID:17901888.
15. Martin, G.R., and Wallace, J.L. 2006. Gastrointestinal inflammation: a central component of mucosal defense and repair. Exp. Biol. Med. (Maywood), 231: 130-137. PMID:16446488.
16. Matsumoto, Y., Kanamoto, K., Kawakubo, K., Aomi, H., Matsumoto, T., Ibayashi, S., and Fujishima, M. 2001. Gastroprotective and vasodilatory effects of epidermal growth factor: the role of sensory afferent neurons. Am. J. Physiol. Gastrointest. Liver Physiol. 280: G897-G903. PMID:11292598.
17. Mozsik, G., Szolcsanyi, J., and Domotor, A. 2007. Capsaicin research as a new tool to approach of the human gastrointestinal physiology, pathology and pharmacology. Inflammopharmacology, 15: 232-245. doi:10.1007/s10787-007- 1584-2. PMID:18236014.
18. Ohno, T., Hattori, Y., Komine, R., Ae, T., Mizuguchi, S., Arai, K., et al. 2008. Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. Gastroenterology, 134: 215-225. doi:10.1053/j.gastro.2007.10.001. PMID:18054007.
19. Okajima, K., and Harada, N. 2006. Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications. Curr. Med. Chem. 13: 2241-2251. doi:10.2174/092986706777935131. PMID:16918352.
20. Peng, J., Xiao, J., Ye, F., Deng, H.W., and Li, Y.J. 2000. Inhibition of cardiac tumor necrosis factor-alpha production by calcitonin gene-related peptide-mediated ischemic preconditioning in isolated rat hearts. Eur. J. Pharmacol. 407: 303-308. doi:10.1016/S0014-2999(00)00702-0. PMID:11068026.
21. Qin, X.P., Zeng, S.Y., Li, D., Chen, Q.Q., Luo, D., Zhang, Z., et al. 2007. Calcitonin gene-related peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. J. Cardiovasc. Pharmacol. 50: 654-659. PMID:18091582.
22. Qui, B.S., Mei, Q.B., Liu, L., and Tchou-Wong, K.M. 2004. Effects of nitric oxide on gastric ulceration induced by nicotine and cold-restraint stress. World J. Gastroenterol. 10: 594-597. PMID:14966924.
23. Tang, W.J., Hu, C.P., Chen, M.F., Deng, P.Y., and Li, Y.J. 2006. Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level. Can. J. Physiol. Pharmacol. 84: 163-171. doi:10.1139/y05-156. PMID:16900942.
24. Tran, C.T., Leiper, J.M., and Vallance, P. 2003. The DDAH/ ADMA/NOS pathway. Atheroscler. Suppl. 4: 33-40. doi:10.1016/S1567-5688(03)00032-1. PMID:14664901.
25. Wang, L., Hu, C.P., Deng, P.Y., Shen, S.S., Zhu, H.Q., Ding, J.S., et al. 2005. The protective effects of rutaecarpine on gastric mucosa injury in rats. Planta Med. 71: 416-419. doi:10.1055/s-2005-864135. PMID:15931578.
26. Wang, L., Zhou, Y., Peng, J., Zhang, Z., Jiang, D.J., and Li, Y.J. 2008. Role of endogenous nitric oxide synthase inhibitor in gastric mucosal injury. Can. J. Physiol. Pharmacol. 86: 97-104. doi:10.1139/Y08-003. PMID:18418436.