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9-(3′-Azido-5′-O-tert-butyldiphenylsilyl- 3′-deoxy-β-D-xylofuranos-1-yl)adenine (6, To a stirred solution of 5 (52 mg, 0.11 mmol) in DMF (1 mL, were added NaN 3 (42 mg, 0.69 mmol) and H2O (0.3 mL, The reaction mixture was precisely warmed to 78-80°C for 20 h, then quenched with sat. NaHCO3 solution and diluted with EtOAc. The layers were separated and the aqueous portion was washed with EtOAc (3 x, The combined organic extracts were washed with 10% aq LiCl (3 x) to remove the residual DMF, washed once with brine, dried over anhyd MgSO4, filtered and concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (EtOAc-toluene, 1:1, 3:1, 5:1, 7:1; EtOAc-toluene-MeOH, 7:1:0.5) to afford 6 as a white solid (47 mg, 80, mp 181°C (uncorrected, R f 0.40 (EtOAc-toluene, 4:1, 1H NMR 300 MHz, DMSO-d
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3Si (669.89): 670.3644; found: 670.3649. 9-[5′-O-tert- Butyldiphenylsilyl-3′-N-(α-N- fluorenylmethoxycarbonyl-p-methoxy-L- phenylalanyl)amido-3′-deoxy-β-D-xylofuranos-1-yl)
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