Dose metrics in the acquisition of skin sensitization: Thresholds and importance of dose per unit area

Regulatory Toxicology and Pharmacology

Volumn 52, Issue 1, 2008, Pages 39-45

  Kimber, Ian ^a   Dearman, Rebecca J ^a   Basketter, David A ^b   Ryan, Cindy A ^c   Gerberick, G Frank ^c   McNamee, Pauline M ^c   Lalko, Jon ^d   Api, Anne Marie ^d  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

Author keywords

Dermal exposure; Langerhans cells; Quantitative risk assessment; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ALLERGEN;

ARTICLE; CONTACT DERMATITIS; DOSE PER UNIT AREA; DOSE RESPONSE; DOSIMETRY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNE RESPONSE; NORMAL HUMAN; PRIORITY JOURNAL; RISK MANAGEMENT; SKIN ALLERGY; SKIN SENSITIVITY; SKIN SENSITIZATION;

ALLERGENS; ANIMALS; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; HUMANS; RISK ASSESSMENT; RISK MANAGEMENT; SKIN TESTS;

EID: 54249093847     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.01.010     Document Type: Article

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