Intracellular concentration of the HIV protease inhibitors indinavir and saquinavir in human endothelial cells

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 4, 2001, Pages 487-490

  Armbruster, Christine ^a,d   Vorbach, H ^a   Steindl, F ^b   El Menyawi, I ^c  

^a Pulmologisches Zentrum   (Austria)

^b UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d NONE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

INDINAVIR; PROTEINASE INHIBITOR; SAQUINAVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL LEVEL; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE CARRIER; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CONCENTRATION; DRUG EXPOSURE; DRUG MONITORING; ENDOTHELIUM CELL; EXTRACELLULAR SPACE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INCUBATION TIME; SUPERNATANT; TARGET CELL; TIME; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

EID: 0035048197     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.4.487     Document Type: Article

References (12)

1. Human immunodeficiency virus-1-tat protein induces the cells surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells
2. HIV-1 infection alters monocyte interactions with human microvascular endothelial cells
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5. Culture of human endothelial cells derived from umbilical veins
6. Determination of L 735524, an human immunodeficiency virus protease inhibitor, in human plasma and urine via high performance liquid chromatography with column switching
7. Simultaneous quantitative determination of the HIV protease inhibitors amprenavir, indinavir, nelfinavir, ritonavir, and saquinavir in human plasma by ion-pair high-performance liquid chromatography with ultraviolet detection
8. Quantitative evaluation of parenchymal liver cell volume and total hepatocyte number in cirrhotic patients
9. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
10. Protease inhibitors in patient with HIV disease
11. Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells
12. The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells