Combating endometriosis by blocking proteasome and nuclear factor-κB pathways

Human Reproduction

Volumn 23, Issue 11, 2008, Pages 2458-2465

  Celik, Onder ^a   Hascalik, Seyma ^a   Elter, Koray ^b   Tagluk, M E ^c   Gurates, Bilgin ^d   Aydin, N E ^a  

^a INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b EuroFertil Center for Human Reproduction   (Turkey)

^c INONU UNIVERSITY   (Turkey)

^d FIRAT UNIVERSITY   (Turkey)

Author keywords

Endometriosis; Inflammation; NF B inhibitor; Proteasome inhibitor

Indexed keywords

BORTEZOMIB; CD31 ANTIGEN; CD34 ANTIGEN; CYCLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KI 67 ANTIGEN; PROTEASOME; PROTEASOME INHIBITOR; PYRROLIDINE DITHIOCARBAMATE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CELL VACUOLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; ENDOMETRIOSIS; ENDOTHELIUM CELL; FEMALE; GROWTH INHIBITION; IMMUNOHISTOCHEMISTRY; IMPLANT; IN VIVO STUDY; INHIBITION KINETICS; LAPAROTOMY; NONHUMAN; RAT; STROMA CELL; WISTAR RAT;

ANIMALIA; RATTUS;

EID: 54149113179     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/den246     Document Type: Article

References (41)

1. Adams J, Palombella VJ, Sausville EA, Johnson J, Destree A, Lazarus DD, Maas J, Pien CS, Prakash S, Elliott PJ. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999;59:2615- 2622.
2. Arici A. Local cytokines in endometrial tissue: the role of interleukin-8 in the pathogenesis of endometriosis. Ann N Y Acad Sci 2002;955:101-109.
3. Baldwin AS, Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-683.
4. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066- 1071.
5. Bruck R, Aeed H, Schey R, Matas Z, Reifen R, Zaiger G, Hochman A, Avni Y. Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats. J Hepatol 2002;36:370-377.
6. Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, Serraino I, Britti D, Mazzullo G, Caputi AP, Thiemermann C. Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation. Br J Pharmacol 2002;135:496-510.
7. D'Acquisto F, May MJ, Ghosh S. Inhibition of nuclear factor kappa B (NF-B): an emerging theme in anti-inflammatory therapies. Mol Interv 2002;2:22-35.
8. Demirbilek S, Akin M, Gurunluoglu K, Aydin NE, Emre MH, Tas E, Aksoy RT, Ay S. The NF-kappaB inhibitors attenuate hepatic injury in bile duct ligated rats. Pediatr Surg Int 2006;8:655-663.
9. Dogan E, Saygili U, Posaci C, Tuna B, Caliskan S, Altunyurt S, Saatli B. Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib. Fertil Steril 2004;82:1115-1120.
10. Fan W, Yanase T, Morinaga H, Mu YM, Nomura M, Okabe T, Goto K, Harada N, Nawata H. Activation of peroxisome proliferator-activated receptor-gamma and retinoid X receptor inhibits aromatase transcription via nuclear factor-kappaB. Endocrinology 2005;146:85-92.
11. Fernández-Shaw S, Marshall JM, Hicks B, Barlow DH, Starkey PM. Plasminogen activators in ectopic and uterine endometrium. Fertil Steril 1995;63:45-51.
12. Ferreira V, van Dijk KW, Groen AK, Vos RM, van der Kaa J, Gijbels MJ, Havekes LM, Pannekoek H. Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation. Atherosclerosis 2007;192:283-290.
13. Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16:225-260.
14. Gross GH. A technique for sustained synchronization of hamster estrous cycles by hormonal means. Horm Behav 1977;9:23-31.
15. Guo SW. Nuclear factor-kappab (NF-kappaB): an unsuspected major culprit in the pathogenesis of endometriosis that is still at large? Gynecol Obstet Invest 2007;63:71-97.
16. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett 2006;398:300-305.
17. Ho HN, Wu MY, Yang YS. Peritoneal cellular immunity and endometriosis. Am J Reprod Immunol 1997;38:400-412.
18. Horie S, Harada T, Mitsunari M, Taniguchi F, Iwabe T, Terakawa N. Progesterone and progestational compounds attenuate tumor necrosis factor alpha-induced interleukin-8 production via nuclear factor kappa B inactivation in endometriotic stromal cells. Fertil Steril 2005;83: 1530-1535.
19. Ilad RS, Fleming SD, Bebington CR, Murphy CR. Ubiquitin is associated with the survival of ectopic stromal cells in endometriosis. Reprod Biol Endocrinol 2004;2:69.
20. Israël A. The IKK complex: an integrator of all signals that activate NF-kappaB? Trends Cell Biol 2000;10:129-133.
21. Krunkosky TM, Martin LD, Fischer BM, Voynow JA, Adler KB. Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. Free Radic Biol Med 2003;35:1158-1167.
22. Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-kappaB: its role in health and disease. J Mol Med 2004;82:434-448.
23. Lähde M, Korhonen R, Moilanen E. Regulation of nitric oxide production in cultured human T84 intestinal epithelial cells by nuclear factor-kappa B-dependent induction of inducible nitric oxide synthase after exposure to bacterial endotoxin. Aliment Pharmacol Ther 2000;14:945-954.
24. Lebovic DI, Chao VA, Martini JF, Taylor RN. IL-1beta induction of RANTES (regulated upon activation, normal T cell expressed and secreted) chemokine gene expression in endometriotic stromal cells depends on a nuclear factor-kappaB site in the proximal promoter. J Clin Endocrinol Metab 2001;86:4759-4764.
25. Lin YJ, Lai MD, Lei HY, Wing LY. Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model. Endocrinology 2006;147:1278-1286.
26. Long SM, Laubach VE, Tribble CG, Kaza AK, Fiser SM, Cassada DC, Kern JA, Kron IL. Pyrrolidine dithiocarbamate reduces lung reperfusion injury. J Surg Res 2003;112:12-18.
27. Matsuzaki S, Canis M, Vaurs-Barriere C, Boespflug-Tanguy O, Dastugue B, Mage G. DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection. Fertil Steril 2005;84:1180-1190.
28. McKay LI, Cidlowski JA. Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways. Endocr Rev 1999;20:435-459.
29. Mizumoto H, Saito T, Ashihara K, Nishimura M, Takehara M, Tanaka R, Ito E, Kudo R. Expression of matrix metalloproteinases in ovarian endometriomas: immunohistochemical study and enzyme immunoassay. Life Sci 2002;71:259-273.
30. Muià C, Mazzon E, Maiere D, Zito D, Di Paola R, Domenico S, Crisafulli C, Britti D, Cuzzocrea S. Pyrrolidine dithiocarbamate reduced experimental periodontitis. Eur J Pharmacol 2006;539:205-210.
31. Németh ZH, Deitch EA, Szabó C, Haskó G. Pyrrolidine dithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett 2003;85:41-46.
32. Orlowski RZ, Stinchcombe TE, Mitchell BS, Shea TC, Baldwin AS, Stahl S, Adams J, Esseltine DL, Elliott PJ, Pien CS et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20:4420-4427.
33. Sakamoto Y, Harada T, Horie S, Iba Y, Taniguchi F, Yoshida S, Iwabe T, Terakawa N. Tumor necrosis factor-alpha-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kappa B activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab 2003;88:730-735.
34. Varma R, Rollason T, Gupta JK, Maher ER. Endometriosis and the neoplastic process. Reproduction 2004;127:293-304.
35. Vernon MW, Wilson EA. Studies on the surgical induction of endometriosis in the rat. Fertil Steril 1985;44:684-694.
36. Wang F, He YL, Peng DX, Liu MB. Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis. Di Yi Jun Yi Da Xue Xue Bao 2005;25:703-705.
37. Wieser F, Vigne JL, Ryan I, Hornung D, Djalali S, Taylor RN. Sulindac suppresses nuclear factor-kappaB activation and RANTES gene and protein expression in endometrial stromal cells from women with endometriosis. J Clin Endocrinol Metabol 2005;90:6441-6447.
38. Wu MH, Wang CA, Lin CC, Chen LC, Chang WC, Tsai SJ. Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab 2005;90:286-295.
39. Wu MY, Ho HN. The role of cytokines in endometriosis. Am J Reprod Immunol 2003;49:285-296.
40. Yamauchi N, Harada T, Taniguchi F, Yoshida S, Iwabe T, Terakawa N. Tumor necrosis factor-alpha induced the release of interleukin-6 from endometriotic stromal cells by the nuclear factor-kappaB and mitogen-activated protein kinase pathways. Fertil Steril 2004;82:1023-1028.
41. Zeitvogel A, Baumann R, Starzinski-Powitz A. Identification of an invasive, N-cadherin-expressing epithelial cell type in endometriosis using a new cell culture model. Am J Pathol 2001;159:1839-1852.