Nitric oxide: The missing lusitrope in failing myocardium

European Heart Journal

Volumn 29, Issue 20, 2008, Pages 2453-2455

  Bronzwaer, Jean G F ^a   Paulus, Walter J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; DIMETHYLARGININASE; DOBUTAMINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MONOMETHYLARGININE; N(G),N(G) DIMETHYLARGININE; NEBIVOLOL; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN ARGININE METHYLTRANSFERASE; SUBSTANCE P; SYMMETRIC DIMETHYLARGININE; TROPONIN I; UNCLASSIFIED DRUG;

BETA ADRENERGIC STIMULATION; CARDIOMYOPATHY; CELL COMPARTMENTALIZATION; DIASTOLIC DYSFUNCTION; DISEASE COURSE; EDITORIAL; EXPERIMENTAL DOG; EXPERIMENTAL MODEL; EXPERIMENTAL RAT; FOREARM BLOOD FLOW; HEART FUNCTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FILLING; HEART LEFT VENTRICLE FILLING PRESSURE; HEART LEFT VENTRICLE MUSCLE; HEART MUSCLE CONTRACTILITY; HEART VENTRICLE FILLING; HUMAN; LUSITROPIC ACTIVITY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIDE EFFECT; SMOOTH MUSCLE RELAXATION; SYSTOLIC HEART FAILURE;

ANIMALS; DOGS; HEART FAILURE, SYSTOLIC; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VENTRICULAR DYSFUNCTION, LEFT;

EID: 54149083246     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehn393     Document Type: Editorial

References (15)

1. Paulus WJ, Frantz S, Kelly RA. Nitric oxide and cardiac contractility in human heart failure: time for reappraisal. Circulation 2001;104:2260-2262.
2. Paulus WJ, Bronzwaer JGF. Nitric oxide's role in the heart: control of beating or breathing? Am J Physiol 2004;287:H8-H13.
3. Zhang YH, Zhang MH, Sears CE, Emanuel K, Redwood C, El-Armouche A, Kranias EG, Casadei B. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice. Circ Res. 2008;102:242-249.
4. Wilson Tang WH, Tong W, Shrestha K, Wang Z, Levison BS, Delfraino B, Hu B, Troughton RW, Klein AL, Hazen SL. Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure. Eur Heart J 2008;29:2506-2513. First published on August 6, 2008. doi:10.1093/eurheartj/ehn360.
5. Elesber AA, Redfield MM, Rihal CS, Prasad A, Lavi S, Lennon R, Mathew V, Lerman LO, Lerman A. Coronary endothelial dysfunction and hyperlipidemia are independently associated with diastolic dysfunction in humans. Am Heart J 2007;153:1081-1087.
6. Tschöpe C, Bock CT, Kasner M, Noutsias M, Westermann D, Schwimmbeck PL, Pauschinger M, Poller WC, Kühl M, Kandolf R, Schultheiss HP. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation 2005;111:879-886.
7. Van Heerebeek L, Hamdani N, Handoko L, Falcao-Pires I, Musters RJ, Kupreishvili K, Ijsselmuiden AJJ, Schalkwijk CG, Bronzwaer JGF, Diamant M, Borbely A, van der Velden J, Stienen GJM, Laarman GJ, Niessen HWM, Paulus WJ. Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation endproducts and myocyte resting tension. Circulation 2008;117:43-51.
8. Mebazaa A, De Keulenaer GW, Paqueron X, Andries LJ, Ratajczak P, Lanone S, Frelin C, Longrois D, Payen D, Brutsaert DL, Sys SU. Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, prostaglandins, and nitric oxide. Circulation 2001;104:3137-3144.
9. Pinsky DJ, Patton S, Mesaros S, Brovkovych V, Kubaszewski E, Grunfeld S, Malinski T. Mechanical transduction of nitric oxide synthesis in the beating heart. Circ Res 1997;81:372-379.
10. Linke WA. Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. Cardiovasc Res 2008;77:637-648.
11. Loyer X, Gomez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Benitah JP, Samuel JL, Heymes C. Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation 2008;117:3187-3198.
12. Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction. Circ Res 2004;94:1256- 1262.
13. Recchia FA, McConnell PL, Bernstein RD, Vogel TR, Xu X, Hintze TH. Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog. Circ Res 1998;83:969-979.
14. Paulus WJ, Kästner S, Vanderheyden M, Shah AM, Drexler H. Myocardial contractile effects of L-arginine in the human allograft. J Am Coll Cardiol 1997;29:1332-1338.
15. Nodari S, Metra M, Dei Cas L. Beta-blocker treatment of patients with diastolic heart failure and arterial hypertension. A prospective, randomized, comparison of the long-term effects of atenolol vs. nebivolol. Eur J Heart Fail 2003;5:621-627.