Identification of the human Nα-acetyltransferase complex B (hNatB): A complex important for cell-cycle progression

Biochemical Journal

Volumn 415, Issue 2, 2008, Pages 325-331

  Starheim, Kristian K ^a   Arnesen, Thomas ^a,b   Gromyko, Darina ^a   Ryningen, Anita ^b   Varhaug, Jan Erik ^a,b   Lillehaug, Johan R ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Cell cycle; Human MDM20; Human N acetyltransferase 3 (hNAT3); Human N acetyltransferase B (hNatB); Immunoprecipitation; Protein N terminal acetylation

Indexed keywords

ACETYLATION; AMINES; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CYTOLOGY; PELLETIZING; PORT TERMINALS; PROBABILITY DENSITY FUNCTION; SEDIMENTATION;

CELL CYCLE; HUMAN MDM20; HUMAN N-ACETYLTRANSFERASE 3 (HNAT3); HUMAN N-ACETYLTRANSFERASE B (HNATB); IMMUNOPRECIPITATION;

CELLS;

ACYLTRANSFERASE; ACYLTRANSFERASE 3; AMINO ACID ACETYLTRANSFERASE; AMINO ACID ACETYLTRANSFERASE COMPLEX B; ASPARTIC ACID; METHIONINE; MITOCHONDRIAL PROTEIN; PEPTIDE DERIVATIVE; POLYPEPTIDE; PROTEIN MDM20; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL FRACTIONATION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME STRUCTURE; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RIBOSOME; SEQUENCE HOMOLOGY; THYROID CANCER; VERTEBRATE;

ACETYLATION; ACETYLTRANSFERASES; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOPRECIPITATION; MUTATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EUKARYOTA; VERTEBRATA;

EID: 54049149934     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080658     Document Type: Article

References (28)

1. Polevoda, B. and Sherman, F (2003) Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem. Biophys. Res. Commun. 308, 1-11
2. Kendall, R. L., Yamada, R. and Bradshaw, R. A. (1990) Cotranslational amino-terminal processing. Methods Enzymol. 185, 398-407
3. Gautschi, M., Just, S., Mun, A., Ross, S., Rucknagel, R, Dubaquie, Y. Ehrenhofer-Murray, A. and Rospert, S. (2003) The yeast Nα-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol. Cell. Biol. 23, 7403-7414
4. Polevoda, B. and Sherman, F (2000) Nα-terminal acetylation of eukaryotic proteins. J. Biol. Chem. 275, 36479-36482
5. Polevoda, B., Cardillo, T S.. Doyle. T. C., Bedi, G. S. and Sherman, F (2003) Nat3p and Mdm20p are required for function of yeast NatB Nα-terminal acetyltransferase and of actin and tropomyosin. J. Biol. Chem. 278, 30686-30697
6. Polevoda, B. and Sherman, F (2003) N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J. Mol. Biol. 325, 595-622
7. Singer, J. M. and Shaw, J. M. (2003) Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc. Natl. Acad. Sci. U.SA. 100, 7644-7649
8. Caesar, R. and Blomberg, A. (2004) The stress-induced Tfs1p requires NatB-mediated acetylation to inhibit carboxypeptidase Y and to regulate the protein kinase A pathway. J. Biol. Chem. 279, 38532-38543
9. Caesar, R., Warringer, J. and Blomberg, A. (2006) Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Eukaryot. Cell 5, 368-378
10. Arnesen, T. Anderson, D., Baldersheim, C., Lanotte, M.. Varhaug. J. E. and Lillehaug, J. R. (2005) Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Biochem. J. 386, 433-443
11. Sugiura, N., Adams, S. M. and Corriveau, R. A. (2003) An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development. J. Biol. Chem. 278, 40113-40120
12. Wenzlau, J. M.. Garl, F J.. Simpson, P, Stenmark, K. R., West, J., Artinger, K. B., Nemenoff, R. A. and Weiser-Evans. M. C. (2006) Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development. Circ. Res. 98, 846-855
13. Fisher, T S., Etages, S. D., Hayes, L.. Crimin. K. and Li, B. (2005) Analysis of ARD1 function in hypoxia response using retroviral RNA interference. J. Biol. Chem. 280, 17749-17757
14. Lim, J. H,, Park, J. W. and Chun, Y. S. (2006) Human arrest defective 1 acetylates and activates β-catenin, promoting lung cancer cell proliferation. Cancer Res. 66, 10677-10682
15. Fluge, O., Bruland, o., Akslen, L. A., Varhaug. J. E. and Lillehaug, J. R. (2002) NATH, a novel gene overexpressed in papillary thyroid carcinomas. Oncogene 21, 5056-5068
16. Line, A., Stengrevics, A., Slucka, Z., Li, G., Jankevics. E. and Rees, R. C. (2002) Serological identification and expression analysis of gastric cancer-associated genes. Br. J. Cancer 86, 1824-1830
17. Ren, T., Jiang, B., Jin, G., Li, J., Dong. B.. Zhang, J., Meng, L., Wu, J. and Shou, C. (2008) Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer Lett. 264, 83-92
18. Arnesen, T., Gromyko, D., Pendino, F, Ryningen, A., Varhaug, J. E. and Lillehaug, J. R. (2006) Induction of apoptosis in human cells by RNAi-mediated knockdown of hARD1 and NATH, components of the protein Not-acetyltransferase complex. Oncogene 25, 4350-4360
19. Arnesen, 1. Anderson, D., Torsvilk, J., Halseth, H. B., Varhaug, J. E. and Lillehaug, J. R. (2006) Cloning and characterization of hNAT5/hSAN: an evolutionarily conserved component of the NatA protein N-α-acetyltransferase complex. Gene 371, 291-295
20. Arnesen, T, Gromyko, D., Horvli, O., Fluge, O., Lillehaug, J. and Varhaug, J. E. (2005) Expression of N-acetyl transferase human and human arrest defective 1 proteins in thyroid neoplasms. Thyroid 15, 1131-1136
21. Fluge, O., Haugen, D. R.. Akslen, L. A., Marstad. A.. Santoro, M., Fusco, A., Varhaug, J. E. and Lillehaug, J. R. (2001) Expression and alternative splicing of c-ret RNA in papillary thyroid carcinomas. Oncogene 20, 885-892
22. Vedeler, A., Pryme, I. F and Hesketh, J. E. (1991) The characterization of free, cytoskeletal and membrane-bound polysomes in Krebs II ascites and 3T3 cells. Mol, Cell. Biochem. 100, 183-193
23. Polevoda, B., Brown, S., Cardillo, T. S.. Rigby, S. and Sherman, F (2008) Yeast Nα-terminal acetyltransferases are associated with ribosomes. J. Cell. Biochem. 103, 492-508
24. Hofmann. I. and Munro, S. (2006) An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. J. Cell Sci, 119, 1494-1503
25. Ghosh, S. and Karin, M. (2002) Missing pieces in the NF-KB puzzle. Cell 109 (Suppl.), S81-S96
26. Baldwin, A. S. (2001) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-KB, J. Clin. Invest. 107, 241-246
27. Deng, C., Zhang, P, Harper, J. W., Elledge, S. J. and Leder, P. (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684
28. Yu, J. and Zhang. L. (2005) The transcriptional targets of p53 in apoptosis control. Biochem. Biophys. Res. Commun. 331, 851-858