Effect of oil-in-water submicron emulsion surface charge on oral absorption of a poorly water-soluble drug in rats

Drug Delivery

Volumn 15, Issue 8, 2008, Pages 503-514

  Poullain Termeau, Stéphanie ^a,d   Crauste Manciet, Sylvie ^a   Brossard, Denis ^a   Muhamed, Saleh ^a   Nicolaos, Georges ^a   Farinotti, Robert ^b   Barthélémy, Christine ^c   Robert, Hugues ^c   Odou, Pascal ^c  

^a UNIV PARIS SUD   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIV LILLE   (France)

^d CENTRE HOSPITALIER INTERCOMMUNAL DE CRÉTEIL   (France)

Author keywords

Absorption; Conscious rat; Griseofulvin; Oral bioavailability; Stearylamine; Submicron o w emulsion; Surface charge

Indexed keywords

EMULSIFYING AGENT; GRISEFULLINE; GRISEOFULVIN; LIPOID E80; LIPOID S40; MIGLYOL; OCTADECYLAMINE; OIL; PHOSPHATIDYLCHOLINE; POLYSORBATE; POLYSORBATE 85; TRIACETIN; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; EMULSION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARAMETER; PARTICLE SIZE; PH; PLASMA CONCENTRATION-TIME CURVE; POLYDISPERSITY INDEX; PRIORITY JOURNAL; RAT; SUBMICRON EMULSION; SURFACE CHARGE; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EMULSIONS; GRISEOFULVIN; MALE; OILS; RATS; RATS, WISTAR; SOLUBILITY; WATER;

EID: 54049121403     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540802321792     Document Type: Article

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