α-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat

Shock

Volumn 30, Issue 4, 2008, Pages 411-416

  Atkins, James L ^a   Hammamieh, Rasha ^a   Jett, Marti ^a   Gorbunov, Nikolai V ^b   Asher, Ludmila V ^a   Kiang, Juliann G ^b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Defensin 4; ADMA; Hemorrhage; Paneth cell; Reg 2

Indexed keywords

ALPHA DEFENSIN; N(G),N(G) DIMETHYLARGININE; PHOSPHOLIPASE A2;

ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD VOLUME; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOREACTIVITY; LYMPH; LYMPH FLOW; MALE; MESENTERY; NONHUMAN; PANETH CELL; PROTEIN FOLDING; RAT;

ALPHA-DEFENSINS; ANESTHESIA; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ARGININE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMORRHAGE; INFLAMMATION; INTESTINES; LYMPH NODES; MALE; PHOSPHOLIPASES A2; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 54049115895     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e31816a71cb     Document Type: Article

References (37)

1. Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV: Multiple-organ-failure syndrome. Arch Surg 121:196-208, 1986.
2. Deitch EA, Xu D, Kaise VL: Role of the gut in the development of injury- and shock-induced SIRS and MODS: the gut-lymph hypothesis, a review. Front Biosci 11:520-528, 2006.
3. Clark JA, Coopersmith CM: Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock 28:384-393, 2007.
4. Salzman NH, Underwood MA, Bevins CL: Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 19:70-83, 2007.
5. Bowdish DM, Davidson DJ, Hancock RE: Immunomodulatory properties of defensins and cathelicidins. Curr Top Microbiol Immunol 306:27-66, 2006.
6. Condon MR, Viera A, D'Alessio M, Diamond G: Induction of a rat enteric defensin gene by hemorrhagic shock. Infect Immun 67:4787-4793, 1999.
7. de Leeuw E, Burks SR, Li X, Kao JP, Lu W: Structure-dependent functional properties of human defensin 5. FEBS Lett 581:515-520, 2007.
8. Boger RH, Bode-Boger SM, Tsao PS, Lin PS, Chan JR, Cooke JP: An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. J Am Coll Cardiol 36:2287-2295, 2000.
9. Wells SM, Holian A: Asymmetric dimethylarginine induces oxidative and nitrosative stress in murine lung epithelial cells. Am J Respir Cell Mol Biol 6:520-528, 2007.
10. Nijveldt RJ, Teerlink T, van der Hoven B, Siroen MP, Kuik DJ, Rauwerda JA, van Leeuwen PA: Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr 22:23-30, 2003.
11. O'Dwyer MJ, Dempsey F, Crowley V, Kelleher DP, McManus R, Ryan T: Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. Crit Care 10: R139, 2006.
12. Nijveldt RJ, Siroen MP, Teerlink T, van Lambalgen AA, Rauwerda JA, van Leeuwen PA: Gut and liver handling of asymmetric and symmetric dimethylarginine in the rat under basal conditions and during endotoxemia. Liver Int 24:510-518, 2004.
13. Bollman JL, Cain JC, Grindly JH: Techniques for the collection of lymph from the liver, small intestine or thoracic duct of the rat. J Lab Clin Med 33: 1349-1352, 1948.
14. Atkins JL, Day BW, Handrigan MT, Zhang Z, Pamnani MB, Gorbunov NV: Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage. J Appl Physiol 100:1267-1277, 2006.
15. Kiang JG, Bowman PD, Wu BW, Hampton N, Kiang AG, Zhao B, Juang YT, Atkins JL, Tsokos GC: Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. J Appl Physiol 97:564-569, 2004.
16. Gorbunov NV, Asher LV, Ayyagari V, Atkins JL: Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma. Exp Mol Pathol 80:11-25, 2006.
17. Ouellette AJ: Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol 306:1-25, 2006.
18. Yoshikawa T, Naruse S, Kitagawa M, Ishiguro H, Nagahama M, Yasuda E, Semba R, Tanaka M, Nomura K, Hayakawa T: Cellular localization of group IIA phospholipase A2 in rats. J Histochem Cytochem 49:777-782, 2001.
19. Ariza A, Lopez D, Castella EM, Munoz C, Zujar MJ, Mate JL: Expression of CD15 in normal and metaplastic Paneth cells of the digestive tract. J Clin Pathol 49:474-477, 1996.
20. Grigat J, Soruri A, Forssmann U, Riggert J, Zwirner J: Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family. J Immunol 179:3958-3965, 2007.
21. Lin PW, Simon PO Jr, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI: Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem 279:19902-19907, 2004.
22. Senthil M, Brown M, Xu DZ, Lu Q, Feketeova E, Deitch EA: Gut-lymph hypothesis of systemic inflammatory response syndrome/multiple-organ dysfunction syndrome: validating studies in a porcine model. J Trauma 60:958-965, 2006.
23. Kaiser VL, Sifri ZC, Dikdan GS, Berezina T, Zaets S, Lu Q, Xu DZ, Deitch EA: Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity. Shock 23:417-425, 2005.
24. Ogle CK, Noel JG, Guo X, Wells DA, Valente JF, Ogle JD, Alexander JW: The ability of endotoxin-stimulated enterocytes to produce bactericidal factors. Crit Care Med 30:428-434, 2002.
25. Vasseur S, Folch-Puy E, Hlouschek V, Garcia S, Fiedler F, Lerch MM, Dagorn JC, Closa D, Iovanna JL: p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I. J Biol Chem 279:7199-7207, 2004.
26. Tran CT, Leiper JM, Vallance P: The DDAH/ADMA/NOS pathway. Atheroscler Suppl 4:33-40, 2003.
27. Bulau P, Zakrzewicz D, Kitowska K, Leiper J, Gunther A, Grimminger F, Eickelberg O: Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am J Physiol Lung Cell Mol Physiol 292:L18-L24, 2007.
28. Fandriks L, von Bothmer C, Johansson B, Holm M, Bolin I, Pettersson A: Water extract of Helicobacter pylori inhibits duodenal mucosal alkaline secretion in anesthetized rats. Gastroenterology 113:1570-1575, 1997.
29. Teerlink T: ADMA metabolism and clearance. Vasc Med 10(Suppl 1):73-81, 2005.
30. Sydow K, Munzel T: ADMA and oxidative stress. Atherosclerosis Suppl 4:41-51, 2003.
31. Siroen MP, van der Sijp JR, Teerlink T, van Schaik C, Nijveldt RJ, van Leeuwen PA: The human liver clears both asymmetric and symmetric dimethylarginine. Hepatology 41:559-565, 2005.
32. Aneman A, Backman V, Snygg J, von Bothmer C, Fandriks L, Pettersson A: Accumulation of an endogenous inhibitor of nitric oxide synthase during graded hemorrhagic shock. Circ Shock 44:111-114, 1994.
33. Dayal SD, Hauser CJ, Feketeova E, Fekete Z, Adams JM, Lu Q, Xu DZ, Zaets S, Deitch EA: Shock mesenteric lymph-induced rat polymorphonuclear neutrophil activation and endothelial cell injury is mediated by aqueous factors. J Trauma 52:1048-1055, 2002.
34. Sarin EL, Moore EE, Moore JB, Masuno T, Moore JL, Banerjee A, Silliman CC: Systemic neutrophil priming by lipid mediators in post-shock mesenteric lymph exists across species. J Trauma 57:950-954, 2004.
35. Angelo M, Singel DJ, Stamler JS: An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate. Proc Natl Acad Sci U S A 103:8366-8371, 2006.
36. Dezfulian C, Raat N, Shiva S, Gladwin MT: Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res 75: 327-338. 2007.
37. Adams CA Jr, Xu DZ, Lu Q, Deitch EA: Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells. Surgery 129:351-363, 2001.