Safety and Efficacy of the Sonographic Acceleration of the Middle Cerebral Artery Recanalization: Results of the pilot Thrombotripsy Study

Ultrasound in Medicine and Biology

Volumn 34, Issue 11, 2008, Pages 1775-1782

  Skoloudik, David ^a,e   Bar, Michal ^a   Skoda, Ondrej ^b   Vaclavik, Daniel ^c   Hradilek, Pavel ^a   Allendoerfer, Jens ^d   Sanak, Daniel ^e   Hlustik, Petr ^e   Langova, Katerina ^e   Herzig, Roman ^e   Kanovsky, Petr ^e  

^a UNIVERSITY HOSPITAL OSTRAVA   (Czech Republic)

^b City Hospital   (Czech Republic)

^c Vitkovicka nemocnice as   (Czech Republic)

^d UNIVERSITY HOSPITAL GIESSEN   (Germany)

^e PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Artery recanalization; Ischemia; Stroke therapy; Thrombolysis; Ultrasound

Indexed keywords

DIAGNOSIS; ULTRASONIC APPLICATIONS; ULTRASONICS;

ARTERY RECANALIZATION; INTRACEREBRAL HEMORRHAGES; ISCHEMIA; MIDDLE CEREBRAL ARTERY; STROKE THERAPY; THROMBOLYSIS; ULTRASOUND EXAMINATION; ULTRASOUND MONITORING;

PATIENT TREATMENT;

ALTEPLASE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

ADULT; AGED; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; CEREBROVASCULAR SURGERY; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DOPPLER ECHOGRAPHY; DRUG MEGADOSE; ECHOENCEPHALOGRAPHY; FEMALE; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; PRIORITY JOURNAL; RECANALIZATION; SAFETY; SONOTHROMBOTRIPSY; STROKE; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 54049114643     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2008.04.002     Document Type: Article

References (43)

1. Akiyama M., Ishibashi T., and Yamada T. Low-frequency ultrasound penetrates the cranium and enhances thrombolysis in vitro. Neurosorgery 43 (1998) 828-832
2. Alexandrov A.V., Demchuk A.M., Felberg R.A., Christou I., Barber P.A., Burgin W.S., Malkoff M., Wojner A.W., and Grotta J.C. High rate of complete recanalisation and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial Doppler monitoring. Stroke 31 (2000) 610-614
3. Alexandrov A.V., Molina C.A., Grotta J.C., Garami Z., Ford S.R., Alvarez-Sabin J., Montaner J., Saqqur M., Demchuk A.M., Moye L.A., Hill M.D., Wojner A.W., and CLOTBUST Investigators. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med 351 (2004) 2170-2178
4. Allendoerfer J., Goertler M., and von Reutern G.-M. Prognostic relevance of ultra-early Doppler sonography in acute ischemic stroke: A prospective multicentre study. Lancet Neurol 5 (2006) 835-840
5. Behrens S., Daffertshofer M., Spiegel D., and Hennerici M. Low-frequency, low-intensity ultrasound accelerates thrombolysis through the skull. Ultrasound Med Biol 25 (1999) 269-273
6. Behrens S., Spengos K., Daffertshofer M., Schroeck H., Dempfle C.E., and Hennerici M. Transcranial ultrasound-improved thrombolysis: Diagnostic versus therapeutic ultrasound. Ultrasound Med Biol 27 (2001) 1683-1689
7. Daffertshofer M., and Fatar M. Therapeutic ultrasound in ischemic stroke treatment: Experimental evidence. Eur J Ultrasound 16 (2002) 121-130
8. Daffertshofer M., Gass A., Ringleb P., Sitzer M., Sliwka U., Els T., Sedlaczek O., Koroshetz W.J., and Hennerici M.G. Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: Increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: Results of a phase II clinical trial. Stroke 36 (2005) 1441-1446
9. Datta S., Coussios C.C., MsAdory L.E., Tan J., Porter T., Courten-Meyers G., and Holland C.K. Correlation of cavitation with ultrasound enhancement of thrombolysis. Ultrasound Med Biol 32 (2006) 1257-1267
10. Demchuk A.M., Burgin W.S., Christou I., Felberg R.A., Barber P.A., Hill M.D., and Alexandrov A.V. Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity, early recovery, and mortality in patients treated with intravenous tissue plasminogen activator. Stroke 32 (2001) 89-93
11. Eggers J., Seidel G., Koch B., and König I.R. Sonothrombolysis in acute ischemic stroke for patients ineligible for rt-PA. Neurology 64 (2005) 1052-1054
12. Everbach C., and Francis C.D. Cavitation mechanisms in ultrasound accelerated thrombolysis at 1 MHz. Ultrasound Med Biol 26 (2000) 1153-1160
13. Fieschi C., Argentino C., Lenzi G.L., Sacchetti M.L., Toni D., and Bozzao L. Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours. J Neuro Sci 91 (1989) 311-322
14. Flint A.C., Duckwiler G.R., Budzik R.F., Liebeskind D.S., and Smith W.S. Mechanical thrombectomy of intracranial internal carotid occlusion. Pooled results of the MERCI and multi MERCI part I trials. Stroke 38 (2007) 1274-1280
15. Francis C.W., and Behrens S. Ultrasonic thrombolysis. In: Hennerici M., and Meairs S. (Eds). Cerebrovascular ultrasound (2001), Cambridge University Press, Cambridge 404-415
16. Francis C.W., Onundarson P.T., Carstensen E.L., Blinc A., Meltzer R.S., Schwarz K., and Marder J.V. Enhancement of fibrinolysis in vitro by ultrasound. J Clin Invest 90 (1992) 2063-2068
17. Furlan A., Higashida R., Wechsler L., Gent M., Rowley H., Kase C., Pessin M., Ahuja A., Callahan F., Clark W.M., Silver F., and Rivera F. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial. Prolyse in acute cerebral thromboembolism. JAMA 282 (1999) 2003-2011
18. Furuhata H., Ishibashi T., Onoue N., and Abe T. In vivo study on transcranial ultrasonic thrombolysis of low frequency and low intensity with monteplase. Cerebrovasc Dis 11 Suppl. 3 (2001) 6
19. Gerriets T., Goertler M., Stolz E., Postert T., Sliwka U., Schlachetzki F., Seidel G., Weber S., and Kaps M. Feasibility and validity of transcranial duplex sonography in patients with acute stroke. J Neurol Neurosurg Psychiatry 73 (2002) 17-20
20. Goertler M., Allendoerfer J., von Reutern G.-M., and NAIS Study Group. Design of a multicentre study on neurosonology in acute ischemic stroke. A project of the Neurosonology Research Group of the World Federation of Neurology. Eur J Ultrasound 16 (2002) 115-120
21. Harpaz D., Chen X., Francis C.W., Marden V.J., and Meltzer R.S. Ultrasound enhancement of thrombolysis and reperfusion in vitro. J Am Coll Cardiol 21 (1993) 1507-1511
22. Ishibashi T., Akiyama M., Onoue H., Abe T., and Furuhata H. Can transcranial ultrasonication increase recanalization flow with tissue plasminogen activator?. Stroke 33 (2002) 917-925
23. Lev M.H., Segal A.Z., Farkas J., Hossain S.T., Putman C., Hunter G.J., Budzik R., Harris G.J., Buonanno F.S., Ezzeddine M.A., Chang Y., Koroshetz W.J., Gonzalez R.G., and Schwamm L.H. Utility of perfusion-weighted CT imaging in acute middle cerebral artery stroke treated with intra-arterial thrombolysis: Prediction of final infarct volume and clinical outcome. Stroke 32 (2001) 2021-2028
24. Lewandowski C.A., Frankel M., Tomsick T.A., Broderick J., Frey J., Clark W., Starkman S., Grotta J., Spilker J., Khoury J., and Brott T. Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke: Emergency Management of Stroke (EMS) Bridging Trial. Stroke 30 (1999) 2598-2605
25. Luo H., Birnbaum Y., Fishbein M.C., Peterson T.M., Nagai T., Nishioka T., and Siegel R.J. Enhancement of thrombolysis in vivo without skin and soft tissue damage by transcutaneous ultrasound. Thromb Res 89 (1998) 171-177
26. Molina C.A., and Saver J.L. Extending reperfusion therapy for acute ischemic stroke. Emerging pharmacological, mechanical, and imaging strategies. Stroke 36 (2005) 2311-2320
27. Nedelmann M., Eicke B.M., Lierke E.G., Heimann A., Kempski O., and Hopf H.C. Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro. J Ultrasound Med 21 (2002) 649-656
28. Postert T., Federlein J., Przuntek H., and Butner T. Insufficient and absent acoustic temporal bone window: Potential and limitations of transcranial contrast enhanced color-coded sonography and contrast-enhanced power-based sonography. Ultrasound Med Biol 23 (1997) 857-862
29. Prokop A.F., Soltani A., and Roy R.A. Cavitational mechanisms in ultrasound-accelerated fibrinolysis. Ultrasound Med Biol 33 (2007) 924-933
30. Reinhard M., Hetzel A., Krüger S., Kretzer S., Talazko J., Ziyeh S., Weber J., and Els T. Blood-brain barrier disruption by low-frequency ultrasound. Stroke 37 (2006) 1546-1548
31. Rha J.H., and Saver J.L. The impact of recanalization on ischemic stroke outcome: A meta-analysis. Stroke 38 (2007) 967-973
32. Riggs P.N., Francis C.W., Bartos S.R., and Penney D.P. Ultrasound enhancement of rabbit femoral artery thrombolysis. Cardiovasc Surg 5 (1997) 201-207
33. Rother J., Schellinger P.D., Gass A., Siebler M., Villringer A., Fiebach J.B., Fiehler J., Jansen O., Kucinski T., Schoder V., Szabo K., Junge-Hulsing G.J., Hennerici M., Zeumer H., Sartor K., Weiller C., Hacke W., and Kompetenznetzwerk Schlaganfall Study Group. Effect of intravenous thrombolysis on MRI parameters and functional outcome in acute stroke <6 hours. Stroke 33 (2002) 2438-2445
34. Skoloudík D., Bar M., Skoda O., Hradilek P., and Simickova K. Safety and efficacy of thrombotripsy - sonographic acceleration of thrombolysis. Ces a Slov Neurol Neurochir 67 (2004) 57-161
35. Skoloudik D., Bar M., Skoda O., Vaclavik D., Hradilek P., Herzig R., and Kanovsky P. Efficacy of sonothrombotripsy versus sonothrombolysis in recanalization of intracranial arteries. Ces a Slov Neurol Neurochir 3 (2007) 129-133
36. Skoloudik D., Fadrna T., Bar M., Zapletalova O., Zapletal O., Blatny J., Penka M., Langova K., Hlustak P., Herzig R., and Kanovsky P. Changes in hemocoagulation in healthy volunteers after a 1-hour thrombotripsy using a diagnostic 2-4 MHz transcranial probe. J Thromb Thromb (2007) [Epub ahead of print]
37. Spengos K., Behrens S., Daffertshofer M., Dempfle C.E., and Hennerici M. Acceleration of thrombolysis with ultrasound through the cranium in a flow model. Ultrasound Med Biol 26 (2000) 889-895
38. Suchkova V., Baggs R.B., and Francis C.W. Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: Enhancement of thrombolysis and improvement in capillary muscle perfusion. Circulation 101 (2000) 2296-2301
39. Tachibana S., and Koga E. Ultrasonic vibration for boosting fibrinolytic effect of urokinase. Blood Vessel 12 (1981) 450-453
40. The European Stroke Initiative Executive Committee and the EUSI Writing Committee. European stroke initiative recommendations for stroke management - update 2003. Cerebrovasc Dis 16 (2003) 11-337
41. Toni D., Lorenzano S., Puca E., and Prencipe M. The SITS-MOST registry. Neurol Sci 27 Suppl. 3 (2006) 260-262
42. Zaidat O.O., Suarez J.I., Sunshine J.L., Tarr R.W., Alexander M.J., Smith T.P., Enterline D.S., Selman W.R., and Landis D.M. Thrombolytic therapy of acute ischemic stroke: Correlation of angiographic recanalization with clinical outcome. AJNR 26 (2005) 880-884
43. Zanette E.M., Fieschi C., Bozzao L., Roberti C., Toni D., Argentino C., and Lenzi G.L. Comparison of cerebral angiography and transcranial Doppler sonography in acute stroke. Stroke 20 (1989) 899-903