Edelfosine induces an apoptotic process in Leishmania infantum that is regulated by the ectopic expression of Bcl-XL and Hrk

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 10, 2008, Pages 3779-3782

  Alzate, Juan Fernando ^a   Arias, Andrés ^b   Mollinedo, Faustino ^c   Rico, Eva ^b   De La Iglesia Vicente, Janis ^c   Jiménez Ruiz, Antonio ^b  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c Centro de Investigacion del Cancer   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLLYSOPHOSPHOLIPID; EDELFOSINE; HRK PROTEIN; MILTEFOSINE; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; DNA DEGRADATION; LEISHMANIA INFANTUM; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; ANTIPROTOZOAL AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; LEISHMANIA INFANTUM; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHOLIPID ETHERS; PHOSPHORYLCHOLINE; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 54049113489     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01665-07     Document Type: Article

References (11)

1. L expression. Apoptosis 11:161-171.
2. Alzate, J. F., A. A. Arias, D. Moreno-Mateos, A. Alvarez-Barrientos, and A. Jimenez-Ruiz. 2007. Mitochondrial superoxide mediates heat-induced apoptotic-like death in Leishmania infantum. Mol. Biochem. Parasitol. 152:192-202.
3. Lee, N., S. Bertholet, A. Debrabant, J. Muller, R. Duncan, and H. L. Nakhasi. 2002. Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ. 9:53-64.
4. Lux, H., N. Heise, T. Klenner, D. Hart, and F. R. Opperdoes. 2000. Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of etherlipid analogues in Leishmania. Mol. Biochem. Parasitol. 111:1-14.
5. Moreira, M. E., H. A. Del Portillo, R. V. Milder, J. M. Balanco, and M. A. Barcinski. 1996. Heat shock induction of apoptosis in promastigotes of the unicellular organism Leishmania (Leishmania) amazonensis. J. Cell. Physiol. 167:305-313.
6. Paris, C., P. M. Loiseau, C. Bories, and J. Breard. 2004. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob. Agents Chemother. 48:852-859.
7. Pearson, R. D. 2003. Development status of miltefosine as first oral drug in visceral and cutaneous leishmaniasis. Curr. Infect. Dis. Rep. 5:41-42.
8. Sereno, D., P. Holzmuller, I. Mangot, G. Cuny, A. Ouaissi, and J. L. Lemesre. 2001. Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. Antimicrob. Agents Chemother. 45:2064-2069.
9. Verma, N. K., and C. S. Dey. 2004. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob. Agents Chemother. 48:3010-3015.
10. Verma, N. K., G. Singh, and C. S. Dey. 2007. Miltefosine induces apoptosis in arsenite-resistant Leishmania donovani promastigotes through mitochondrial dysfunction. Exp. Parasitol. 116:1-13.
11. Youle, R. J., and A. Strasser. 2007. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9:47-59. 3