Induction of matrix metalloproteinase-1 gene transcription by tumour necrosis factor α via the p50/p50 homodimer of nuclear factor-κ B in activated human hepatic stellate cells

Liver International

Volumn 28, Issue 10, 2008, Pages 1418-1425

  Hozawa, Shigenari ^a   Nakamura, Tetsuya ^b   Nakano, Masaru ^a   Adachi, Masayuki ^a   Tanaka, Hirotoshi ^c   Takahashi, Yoko ^a   Tetsuya, Mine ^d   Miyata, Naoteru ^a   Soma, Hiromitsu ^a   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gene regulation; Human hepatic stellate cell; MMP 1; NF B; p50 p50 homodimer; promoter; TNF

Indexed keywords

CIS ACTING ELEMENT; HOMODIMER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERSTITIAL COLLAGENASE; MESSENGER RNA; PROTEIN P50; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; MUTATIONAL ANALYSIS; NORTHERN BLOTTING; PROMOTER REGION; PROTEIN FUNCTION; RECEPTOR UPREGULATION; STELLATE CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; ZYMOGRAPHY;

BLOTTING, NORTHERN; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATIC STELLATE CELLS; HUMANS; MATRIX METALLOPROTEINASE 1; MUTAGENESIS, SITE-DIRECTED; NF-KAPPA B P50 SUBUNIT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 54049110010     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01883.x     Document Type: Article

References (28)

1. Marra F, Romanelli RG, Giannini C, et al. Monocyte chemotactic protein-1 as a chemoattractant for human hepatic stellate cells. Hepatology 1999; 29: 140-8.
2. Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P. Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology 1997; 112: 522-31.
3. Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 1999; 29: 1760-7.
4. Gressner AM. The cell biology of liver fibrogenesis -an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 1998; 292: 447-52.
5. Arthur MJ. Role of Ito cells in the degradation of matrix in liver. J Gastroenterol Hepatol 1995; 10: S57-62.
6. Iredale JP, Benyon RC, Pickering J, et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998; 102: 538-49.
7. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Aliebhaber S, Brenner DA. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. Mol Cell Biol 1997; 17: 5201-9.
8. Hernandez-Munoz I, de la Torre P, Sanchez-Alcazar JA, et al. Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein. Gastroenterology 1997; 113: 625-40.
9. Chen A, Beno DWA, Davis BH. Suppression of stellate cell type I collagen gene expression involves AP-2 transmodulation of nuclear factor-1-dependent gene transcription. J Biol Chem 1996; 271: 25994-8.
10. Parola M, Pinzani M, Casini A, et al. Induction of procollagen type I gene expression and synthesis in human hepatic stellate cells by 4-hydroxy-2,3-nonenal and other 4-hydroxy-2,3 alkenals is related to their molecular structure. Biochem Biophys Res Commun 1996; 222: 261-4.
11. Houglum K, Buck M, Alcorn J, Contreras S, Bornstein P, Chojkier M. Two different cis-acting regulatory regions direct cell-specific transcription of the collagen alpha 1(I) gene in hepatic stellate cells and in skin and tendon fibroblasts. J Clin Invest 1995; 96: 2269-76.
12. Armendariz-Borunda J, Katayama K, Seyer JM. Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor alpha, and transforming growth factor beta in Ito cells. J Biol Chem 1992; 267: 14316-21.
13. Inagaki Y, Truter S, Greenwel P, et al. Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 1995; 22: 573-9.
14. Murakami K, Abe T, Miyazawa M, et al. Establishment of a new human cell line, LI90, exhibiting characteristics of hepatic Ito (fat-storing) cells. Lab Invest 1995; 72: 731-9.
15. Rao VH, Bridge JA, Neff JR, et al. Expression of 72kDa and 92kDa type IV collagenases from human giant-cell tumor of bone. Clin Exp Metastasis 1995; 13: 420-6.
16. Chouljenko V, Jayachandra S, Rybachuk G, Kousoulas KG. Efficient long-PCR site-specific mutagenesis of a high GC template. Biotechniques 1996; 21: 472-4, 476-8, 480.
17. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 1983; 11: 1475-89.
18. Hellerbrand C, Jobin C, Licato LL, Sartor RB, Brenner DA. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. Am J Physiol 1998; 275: G269-78.
19. Aho S, Rouda S, Kennedy SH, Qin H, Tan EM. Regulation of human interstitial collagenase (matrix metalloproteinase-1) promoter activity by fibroblast growth factor. Eur J Biochem 1997; 247: 503-10.
20. Benbow U, Rutter JL, Lowrey CH, Brinckerhoff CE. Transcriptional repression of the human collagenase-1 (MMP-1) gene in MDA231 breast cancer cells by all-trans-retinoic acid requires distal regions of the promoter. Br J Cancer 1999; 79: 221-8.
21. Pierce RA, Sandefur S, Doyle GA, Welgus HG. Monocytic cell type-specific transcriptional induction of collagenase. J Clin Invest 1996; 97: 1890-9.
22. Vincenti MP, White LA, Schroen DJ, Benbow U, Brinckerhoff CE. Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit Rev Eukaryot Gene Expr 1996; 6: 391-411.
23. Vincenti MP, Coon CI, Brinckerhoff CE. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts. Arthritis Rheum 1998; 41: 1987-94.
24. Schmitz ML, Baeuerle PA. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. Embo J 1991; 10: 3805-17.
25. Zhong H, May MJ, Jimi E, Ghosh S. The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1. Mol Cell 2002; 9: 625-36.
26. Oakley F, Mann J, Nailard S, et al. Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury. Am J Pathol 2005; 166: 695-708.
27. Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW. Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. J Biol Chem 1999; 274: 28491-6.
28. Elsharkawy AM, Wright MC, Hay RT, et al. Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology 1999; 30: 761-9.